Posted by admin on Jun 30, 2024 in |
Natural products have achieved approval globally for assisting healthcare and also disease obstruction. Alkaloids are an important group of diversely distributed, chemically, biologically and commercially significant natural product which have various organic compounds that give different pharmacological activities. The most important and initial step in medicinal plant is extraction because the bioactive compounds need to be extracted from the plant and various techniques are involved like ultrasound assisted extraction, microwave assisted extraction, supercritical fluid extraction, solid phase extraction, liquid-liquid extraction, enzyme assisted extraction etc. alkaloids are obtained from plant, bacteria, fungi and animals. In this paper we gather information about plant alkaloids, classification of plant alkaloids with their different types of extraction techniques, chemical structure and biological sources. Natural products have achieved approval globally for assist healthcare and also disease obstruction. Alkaloids are an important group of diversely distributed, chemically, biologically and commercially significant natural product which have various organic compounds that give different pharmacological activities. Wide range of alkaloids is present in different parts of plants. Different parts...
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Posted by admin on Jun 30, 2024 in |
Diabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-induced oxidative stress, inflammation, and metabolic dysfunction, resulting in peripheral nerve damage. Diagnosis relies on a combination of clinical and electrophysiological assessments. Pharmacotherapy, a pivotal component in DPN management, encompasses analgesics, anticonvulsants, and neurotrophic agents, aiming to alleviate symptoms and impede disease progression. The abstract underscores the need for a multidisciplinary approach and ongoing research to enhance the understanding and treatment of DPN, ultimately improving the quality of life for individuals affected by this...
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Posted by admin on Jun 30, 2024 in |
The increasing demand for natural polymers has fuelled substantial investment in research and development within the pharmaceutical and biotech sectors. Natural polymers, lauded for their biocompatibility, biodegradability, and safety, offer versatile advantages and among these, polysaccharides and proteins stand out. One class of natural polymers, gums, obtained primarily from plants, is gaining prominence in pharmaceuticals, biotechnology, and food industries. Notable examples include Xanthan gum, Guar gum, Locust bean gum (LBG), and Tara gum, all sharing the galactomannan compound at their core. LBG exhibits a range of physical and chemical properties that make it a valuable candidate for drug delivery systems. This natural biopolymer, with its unique characteristics, presents a compelling case for incorporation into oral drug delivery systems. The chemical composition of LBG makes it well-suited for interaction with other natural polymers. This interaction can lead to the development of novel drug delivery systems with controlled-release, improved solubility, and enhanced bioavailability. LBG’s compatibility with various natural polymers offers a wide array of possibilities for formulation enhancement. Pharmaceutical applications of...
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Posted by admin on May 31, 2024 in |
Medicinal plants usage has been continued since olden times for treatment of illness and various diseases internationally. They contain substances which have therapeutics activities and further study of these substances has led to discovery of new drugs. In present days, the medicinal plants play a significant role in the development of plant-based medicines. Myrica esculenta is a plant which belongs to family myricaceae and is found in foothill tracks of Eastern Himalayas, Meghalaya, Nepal, China and Pakistan. Myrica esculenta are rich in flavonoids, tannins, steroids, terpenes. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments and skin diseases and pharmacologically used as anti-bacterial, anti-inflammatory, anti-diabetic, anthelmintic, antioxidants, antipyretics, and wound healing. Research carried out using different in-vitro and in-vivo techniques of biological evaluation support most of these claims. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal...
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Posted by admin on May 31, 2024 in |
Schedule Y has been established under Drugs and Cosmetic Act 1940 and rule 1945 for the conduction of clinical trials. It is referred to fundamentals and guidelines for import and manufacture of original drugs for trade or for clinical trials. Schedule Y provides guidance for conducting various clinical trials in different fields of clinical research, controlling and regulating any new drug prior to their entry into the market. It includes the responsibilities of key authorities such as sponsors, investigators, and ethics committee) and year wise evolutions, as well as the evolution of these guidelines over the years as the review present (sponsor, investigator and ethics committee) and year wise evolution suggested by various authorities. In addition, different phase of clinical trials with their respective roles. This updated study demonstrates the Indian government’s strong commitment to the conduct of trials in India and safeguarding the interests of human subjects. The Suggestive consolidations for improving clinical trials may contribute significantly to strike balance between the interest of the subjects and the growth...
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