Posted by admin on Jan 1, 2012 in |
Excipients form a bulk of the finished dosage forms. They affect various properties in the finished products like patient acceptability, dissolution, bioavailability, rate of release of active ingredients etc. Now a day’s many new means of drug delivery systems are coming up which require new excipients to improve the characteristics of the dosage form. Further new excipients are being discovered which are replacing the older ones by having better desirable characteristics. The novel excipients are developed in such a way that they are more compatible with the active ingredients but there are several hurdles in their development. The establishment of safety of novel excipients is a major hindrance in their development. The evaluation of novel excipients requires huge investments of time and money. As a result, pharmaceutical manufacturers are not interested in evaluating novel excipients in terms of safety and efficacy because any discrepancies in their use may cause delays in the approval of the formulations causing a major loss to the manufacturers. Also there are no well defined...
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Posted by admin on Dec 1, 2011 in |
In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is overcome by microsponge delivery system. Microsponges are tiny sponge like spherical and highly porous micro-sized particles with a unique ability for entrapping actives. They offers programmable release active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active. These MDS’s are closely related to microspheres, and used in the sun screens, creams, ointments, over- the-counter (OTC) skin care preparations, recently used in oral drug as well as biopharmaceuticals (peptides, proteins and DNA-based therapeutics) drug delivery. The present review introduces microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of...
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Posted by admin on Dec 1, 2011 in |
Among the various methods of drying, this article has mentioned only one most important method, “Freeze drying”. This method is mainly used for the drying of thermo labile materials. This method works on the principle of sublimation. This method is divided into 3 steps for its better understanding; these are Freezing, Primary drying, and secondary drying. There are many advantages and disadvantages of this method, but still this is the most useful drying method...
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Posted by admin on Dec 1, 2011 in |
Depression is a heterogenous mood disorder that has been classified and treated in variety of ways. Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment .Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio. A number of medicinal plants and medicine derived from these plants have shown antidepressant properties by virtue of combined effect of their medicinal constituents. The causes of depression are decreased brain levels of monoamines like noradrenaline, dopamine and serotonin. Therefore, drugs restoring the reduced levels of these monoamines in the brain either by inhibiting monoamine oxidase or by inhibiting reuptake of these neurotransmitters might be fruitful in the treatment of depression. The present review is focused on the medicinal plants and plants based formulations having antidepressant activity in animal studies and in...
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Posted by admin on Dec 1, 2011 in |
Tablet that disintegrate rapidly in the mouth are convenient for patient who have difficulty in swallowing conventional dosages forms. Although various formulation technologies like Zydis Technology, Durasolve Technology, Orasolve Technology, Flash Dose Technology, Wow Tab Technology, Flash Tab Technology, Quicksolv Technology, Lyos Technology, Fast Melt Technology and Zip-lets Technology are used. This review highlights numerous techniques to explain the phenomenon of preparing mouth disintegration tablets like Freeze Drying, Molding, Sublimation, Spray Drying, Direct compression, Wet granulation and Dry...
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