Posted by admin on May 31, 2024 in |
Phytosterols, a subclass of steroids, have gained considerable attention in scientific research and nutrition due to their potential health benefits. This article presents an overview of phytosterols, encompassing their sources, chemistry, extraction methods, analytical techniques, and biological activities. Phytosterols, structurally resembling cholesterol, are found abundantly in plants, animals, and fungi. Their physiological roles include influencing membrane fluidity and acting as second messengers in signal transduction pathways. Incorporating phytosterol-rich foods into the diet has been linked to various health benefits, particularly in reducing cholesterol levels, as recognized by regulatory bodies like the European Food Safety Authority and the FDA. The article discusses various extraction methods for phytosterols, emphasizing the need for environmentally friendly approaches to minimize the use of organic solvents. Traditional techniques such as Soxhlet extraction are effective but pose health and environmental concerns, driving the exploration of alternative extraction technologies. Phytosterol chemistry, characterized by specific carbon atoms and side chains, is explored, highlighting their steroid structure and different forms in nature. Analytical methods such as gas chromatography (GC),...
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Posted by admin on May 31, 2024 in |
The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on the utilization of these drugs. Certain pharmaceuticals require a period of 30 to 60 minutes to reach equilibrium in maternal and fetal circulation, albeit at different concentrations and under varying conditions. Variables, including placental potency, dosage, maternal characteristics, drug efficacy, and gestational age at the time of exposure, contribute to the impact of drugs on the fetus. Notably, during the initial three weeks of pregnancy, a developing fetus is more susceptible than the mother. The National Institutes of Health (NIH) has documented spontaneous abortion, allergies, preeclampsia, gestational diabetes, hypertension, depression, and anxiety, as well as mild to severe functional or metabolic abnormalities as commonly reported complications during pregnancy. This review aims to ascertain the transplacental genotoxicity associated with medications employed...
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Posted by admin on May 31, 2024 in |
Hemidesmus indicus (H. indicus), also known as Indian Sarsaparilla or Anantmul, is a plant with diuretic, demulcent, and diphoretic properties. It treats various illnesses, detoxifies the blood, and reduces Vata, Pitta, and Kaphadoshas. It has been shown in pre-clinical trials to reduce illnesses in everyday clinical practice. In order to effectively promote this herbal medicine, clinical trials and patient studies conducted in hospitals are necessary. The intent of this review is to update the numerous medicinal qualities of H. indicus and demonstrate its therapeutic potential, enabling it to be used as an alternative to contemporary or modern medicine to treat a variety of disorders. The taxonomy, pharmacological components, and unique medicinal qualities of H. indicus are all outlined in this paper. It showed a proven effective and beneficial on the long-standing illness, therefore the need of the multicentre clinical trials is needed on the herbal medicine to be used as a complementary approach in...
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Posted by admin on May 31, 2024 in |
Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of the joints. If it is untreated then it leads to destruction of joints, erosion of cartilage and bone and eventually leads to loss of physical function. Since, RA is not complete curable disease, the treatment goals are to reduce the pain and stop/slow further damage. With advancement in the field of molecular biology, a better understanding of disease mechanisms is available which can help in the designing of more effective treatments. Old treatment modes have been optimized and new ones have been produced. Nowadays, different classes of drugs with different mechanism of action are available to control the inflammation and to achieve remission. The aim of this review is to discuss previous and present treatment options for treating RA and its...
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Posted by admin on May 31, 2024 in |
Tuberculosis remains a challenge globally affecting the health of several individuals globally. The emergence of drug resistant tuberculosis has further increased the threat. Despite having several drugs available the peril of the mycobacterium continues to loom. Across the globe several scientists are putting in efforts to come up with newer drugs with novel mechanism of action and belonging to several old as well as newer chemical classes. This review article delves in detail on each of the newer drugs discovered for the treatment and control of the disease. It begins with highlighting the progress of the diseases and its treatment over the years and then probes in-depth into the novel molecules of drugs discovered for the same. This article thus is a concise landscape which underlines the need of novel drug molecules and further highlights the potential of these newer drugs to combat tuberculosis by controlling the spread, shortening its treatment period, and making the treatment affordable to...
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