Posted by admin on Oct 1, 2011 in |
Most of the drugs in the developmental pipeline are emerging from the High-Throughput Screening methodology resulting in increased molecular weights and thus consequential bioavailability problems. The bioavailability issue can be due to insufficient solubility of permeability. Most compounds face the solubility problems. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing. Pharmaceutical approaches to correct the bioavailability are definitely being cost-effective in comparison with chemical approaches which are also time-consuming. Hence various methods of solubility enhancement are being developed. Each technique is with several merits and demerits. To tackle the disadvantages of conventional approaches, newer techniques are developed by many researchers. In this review, an attempt of comparing the conventional and novel techniques is...
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Posted by admin on Oct 1, 2011 in |
G protein-coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. GPCRs are involved in a wide variety of important physiological processes like visual sense, sense of smell, behavioral and mood regulation, regulation of immune system activity and inflammation, autonomic nervous system transmission and cell density sensing. There are two principal signal transduction pathways involving the G protein-linked receptors, cAMP signal pathway and Phosphatidylinositol signal pathway. Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. One of the reasons for the growing public health concern over the rapidly increasing prevalence of obesity in society is its association with the growing incidence...
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Posted by admin on Oct 1, 2011 in |
Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20-200nm and shows narrow size distribution. In this review attention is focused to give the brief regarding formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques are to be used for preparation of nanoemulsions like microfluidization, high pressure homogenization, low energy emulsification and solvent evaporation method and parameter that are to be used for its characterization like droplet size analysis ,viscosity determination, drug content, refractive index, pH, zeta potential, Transmission electron microscopy, thermal stability, release and in vitro skin permeation study. These are applicable in drug...
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Posted by admin on Sep 1, 2011 in |
Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20-200nm and shows narrow size distribution. In this review attention is focused to give the brief regarding formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques are to be used for preparation of nanoemulsions like microfluidization, high pressure homogenization, low energy emulsification and solvent evaporation method and parameter that are to be used for its characterization like droplet size analysis ,viscosity determination, drug content, refractive index, pH, zeta potential, Transmission electron microscopy, thermal stability, release and in vitro skin permeation study. These are applicable in drug...
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Posted by admin on Sep 1, 2011 in |
Cassia tora Linn. (Family: Leguminosae) is well known plant widely distributed in India and other tropical countries. It is an annual under shrub and grows in wild wasteland. Different parts of the plant (Leaves, seed, and root) are reputed for their medicinal value. It is well recognized traditional medicine as laxative and is useful for treatment of leprosy, ringworm infection, ophthalmic, skin diseases and liver disorders. Several chemical compounds such as Anthraquinone glycosides, Naphthopyrone glycosides, Phenolic compounds, Flavonoids etc. have been isolated from this plant. The present review summarizes the scientific information of various aspects of Cassia tora plant used in traditional system of medicine for variety of...
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