Posted by admin on Sep 1, 2011 in |
β- Thalassemia is an inherited genetic disorder which is caused by different kinds of mutations in the HBB gene in chromosome 11. Due to several types of mutation in β- gene, globin chains cannot synthesise completely and free α-globin is highly unstable and readily precipitates bound heme and iron. In β- thalassemia these precipitated iron, repeated blood transfusion and increased gastrointestinal iron absorption lead to iron overload in the body. The increased free iron in blood is responsible for the formation of Reactive Oxygen Species (ROS). If the production of ROS exceeds the capacity of enzymatic and non-enzymatic antioxidants systems to scavenge these species or if these protective systems are compromised, then oxidative stress occurs. This review summarizes the production of ROS, its effect and different drug and plant extract used as an antioxidant as well as chelating agent in thalassemic...
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Posted by admin on Sep 1, 2011 in |
Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together with chitin, chitosan is well thought-out the second most abundant polysaccharide subsequent to cellulose. But in contrast to cellulose, the application of Chitosan in pharmaceutical field is a pretty new development. Recently there are so many formulation were prepared and evaluated within different dosage forms such as ophthalmic, nasal sublingual, buccal, periodontal, gastrointestinal, colon specific, vaginal, transdermal as well as gene carrier which is based on the application of chitosan and its derivatives. Chitosan is biocompatible and show the activities such as antimicrobial and antifungal activities, which makes it a favourable option for biomedical applications. It has been proven to be useful in tissue growth, in tissue repair and accelerating wound-healing...
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Posted by admin on Sep 1, 2011 in |
Extensive research has been carried out from last decades to discover potential constituents from plant sources. Stigmasterol is an important constituent and has been isolated from plants. It is involved in the synthesis of many hormones like progesterone, androgens, estrogens and corticoids. In addition to stigmasterol many of its derivatives like, spinasterol, fucosterol, cyasterone, stigmasterol glucoside, fucosterol epoxide, stigma-4en-3one, 29-fluorostigmasterol etc. have been isolated and their pharmacological aspects has been assessed. This comprehensive account provides information about stigmasterol and its derivatives. The diversity in their pharmacological reports reveals that this constituent is worth further...
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Posted by admin on Sep 1, 2011 in |
In case of cancer, Traditional Chinese medicine-based herbal medicines have gained increasing acceptance worldwide in recent years and are being pursued by pharmaceutical companies as rich resources for drug discovery. For many years, traditional Chinese medicines (TCM) have been applied for the treatment of cancers in China and beyond. Herbal remedies are clearly a complementary and alternative modality used frequently by patients with hemato-oncological neoplasias during the course of their specific treatment. Cancer is a leading cause of death worldwide. There are a lot of cancer causing agents which are divided as physical carcinogens, chemical carcinogens and biological carcinogens. But most of the carcinogens or causes of cancer are related to our lifestyle like diet, habit, occupation, radiation and some infection, etc. Chemoprevention is highly necessary to prevent cancer related preterm death. In this review, we are studied on the herbal medicines, whenever used in cancer treatment and easily available in market. Cancer is a major cause of death, and globally studies are being conducted to prevent cancer or...
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Posted by admin on Aug 1, 2011 in |
Aegle marmelos Corr. (Rutaceae), commonly known as Bael, Bengal Quince is a tree of Indian origin, well known from pre- historic time. Utilization of bael fruit in day-to-day life has a great nutritional, environmental as well as commercial importance. All the parts of this tree including stem, bark, root, leaves, fruit and seeds at all stages of maturity has medicinal virtues and has been used in Ethno-medicine to exploits its medicinal properties including antidiarroheal, antidysentric, antipyretic and anti inflammatory activities. Compounds purified from bael fruit have been proven to have biological potential against several diseases like diabetes, gastric ulcer and hyperlipidaemia. It should also be indicated that the therapeutic activities of few isolated constituents have also proven to possess antibacterial, antiviral, antioxidant and radioprotective activities. Thus the purpose of this abstract is to explore the pharmacological potential of some crude extracts of bael...
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