Posted by admin on Dec 1, 2010 in |
Solid lipid nanoparticles (SLN) are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids. They are introduced in 1990 as an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. They exhibit major advantages such as modulated release, improved bioavailability, protection of chemically labile molecules like retinol, peptides from degradation, cost effective excipients, improved drug incorporation and wide application spectrum. This paper presents an overview about the selection of the ingredients, different ways of SLN production, drug incorporation and release, characterization of SLN quality and structure, Sterilization, storage and stability of SLN dispersions and SLN...
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Posted by admin on Dec 1, 2010 in |
Gene transfer represents a relatively new way for the treatment of rare genetic disorders by changing the expression of a person’s genes. Electroporation is a mechanical method of gene transfer used to introduce polar molecules such as DNA, RNA and Peptides (Heparin, Insulin) into a host cell through the cell membrane. In this procedure, a large electric pulse temporarily disturbs the phospholipid bilayer, allowing molecules like DNA to pass into the cell. With careful control of the strength of the electrical field and the duration of the cell’s exposure to it, the pores will reseal themselves after a short period of time. There are nine ways for gene transfer: 1. Electroporation; 2. Lipid mediated method; 3. Chemical mediated gene transfer; 4. Microinjection; 5. Biolistics; 6. Viral vectors; 7. Transformation; 8. Conjunction; 9. Gene Transfection enhanced by elevated temperature. Among a number of techniques using lipid, viruses or specialty reagents may be cytotoxic, labor intensive and costly while, Electroporation is a simple, inexpensive, safe, non toxic and non viral method....
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Posted by admin on Dec 1, 2010 in |
Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems which employ a structure as a reservoir for the drugs. A number of drugs have reached the market in transdermal delivery form that has become an increasingly acceptable mode for administration of prescription and nonprescription drugs. Transdermal drug delivery system possesses many advantages over conventional modes of drug administration. Ketorolac when combined with tromethamine forms a salt (‘ketorolac tromethamine’), which has a greater aqueous solubility than ketorolac. Ketorolac tromethamine is a Nonsteroidal anti-inflammatory drug useful for short-term management of moderate to severe pain. Ketorolac tromethamine has high analgesic and anti-inflammatory potency; administered orally. The focus of this review article is to bring out different aspect related with the administration and its future impacts on human body after administration of ketorolac in transdermal drug delivery...
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Posted by admin on Dec 1, 2010 in |
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water with in few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research...
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Posted by admin on Dec 1, 2010 in |
Eucalyptus is a diverse genus of flowering trees and shrubs in the myrtle family, Myrtaceae. Different chemical constituents such as Sideroxylonal C, (+)-oleuropeic acid, cypellocarpins A, B and C, cypellogins A, B and C, Leptospermone, Isoleptospermone, grandinol, various essential oils and many others have been isolated from plants of eucalyptus genus. Various eucalyptus species have been reported to possess potent pharmacological actions against diabetes, hepatotoxicity, inflammation, cancer etc. This review article is presented to compile all the updated information on phytochemical and pharmacological activities of Eucalyptus species which have been performed by widely different...
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