Posted by admin on Feb 1, 2010 in |
Multiple sclerosis affects around 2.5 million people worldwide it is one of the most common neurological disorders and cause of disability of young adults, especially in Europe and North America. There is a lack of epidemiological studies from Asia where the prevalence is reported to be low, though, with the availability of more neurologists and magnetic resonance imaging, a larger number of patients are being diagnosed. MS is a slowly progressive, immunologically mediated disease of the central nervous system, characterized by inflammation and demyelination of white matter in the brain and spinal cord. A triad of symptoms clinically characterize Multiple sclerosis: changes in sensation, muscle weakness, ataxia, dysarthria, dysphagia, visual problems, fatigue, acute or chronic pain, bladder and bowel difficulties. The diagnosis of MS is made on the basis of the clinical signs and symptoms, with magnetic resonance imaging (MRI) and other laboratory tests playing a supportive role. All tests are non specific and only provide supportive evidence for diagnosis. The effective management of multiple sclerosis is complex and draws on many disciplines,...
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Posted by admin on Jan 1, 2010 in |
Diabetes and its different types is an age old disease for clinicians since centuries. Many aspects of Diabetes needs to be explored with respect to physiological actions of insulin and the various clinical features of this disease such as tissue complication , since this is life style disease , so proper treatment in relation to diet and anti diabetic agents is emphasized In fact, herbal treatment for diabetes is not new. Plants and plant extracts were used to combat the disease as early as 1550 B.C., with as many as 400 “prescribed” before the development earlier this century of effective medications to control diabetes. In this paper an attempt has been made to give an overview of certain Indian plants with their phytoconstituents and mechanism of action which have been studied for their antidiabetic activity....
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Posted by admin on Jan 1, 2010 in |
Diabetic neuropathy is one of the most serious microvascular complications of diabetes, which appears in about 50% of the patients suffering from diabetes. It is a nerve disorder caused by diabetes, characterized usually by numbness, pain or tingling in the feet or legs, which can lead to serious problems. Patients with diabetic neuropathy suffer from various types of pain. The underlying mechanisms include hyperglycaemia, insulin deficiency, oxidative stress, nitrosative stress, ischaemia, osmolyte accumulation, neurotropic factors deficiency, autoimmune-mediated nerve destruction, alterations in cellular signal pathways and gene expression of proteins. The factors leading to the development of peripheral neuropathy in diabetes are not understood completely, and multiple hypotheses have been advanced which include the polyol pathway, non-enzymatic glycation, oxidative stress, altered neurotropism and apoptosis. At present, there is no clinically proven efficacious drug specifically designated for the treatment of diabetic neuropathy; however, prevention or retardation of the progress of diabetic neuropathy is considered to depend on various antidiabetics, antioxidants, anti-depressants, anticonvulsants, NSAIDs, etc. The new advances in the development of...
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Posted by admin on Jan 1, 2010 in |
Antioxidants are gaining a lot of importance as a panacea for a large number of life-style diseases like aging, cancer, diabetes, cardiovascular and other degenerative diseases etc. owing to our sedentary way of life and stressful existence. Added to these are the deleterious effects of pollution and exposure to harmful chemicals. All the above cause may accumulation of harmful free radicals. The present article includes the detailed exploration of in-vitro and in-vivo models for antioxidant activity....
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