Posted by admin on Sep 30, 2024 in |
The development of effective therapeutic strategies for various remedial conditions often involves the exploration of synergistic interaction between two pharmacophores. The most frequent methods for multidrug therapy combining two or more active ingredients into a single, and creating hybrid molecular entities that can modulate numerous targets interaction gives a synergistic effect. As a result, the structural activity relationship is becoming more and more common in the form of hybrid molecules (multiple ligand approach) such as chalcone-isatin, ferrocene-isatin as well as ferrocene-chalcone combinations possesses multiple biological properties such as antitubercular, anticancer, antibacterial, Antimalarial, anti-inflammatory which having synergistic activity due to their combination as well as their substitutions like electron donating and withdrawing group. The evaluation of synergistic drug combinations offers promise in overcoming challenges such as drug resistance, dose-dependent toxicity, and suboptimal treatment responses. To determine the significance of the notion of molecular hybridization, the pharmacological potency of the hybrid molecules is compared to those of their separate counterparts. This review underscores the promising role of chalcone-isatin, ferrocene-isatin and ferrocene-chalcone...
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Posted by admin on Aug 31, 2024 in |
3D printing (a.k.a. fast prototyping or advanced manufacturing process) is estimated to be a highly innovative technology within the healthcare devices industry and pharmaceutical industry. With the use of digitally controlled material deposition straight from a computer-aided design, 3D printing technology can create 3D pharmaceutical items layer by layer. It facilitates the making of dosage forms such as composite products, personalized products, and products made on demand. Pharmacogenetic and pharmacokinetic features, age, weight, comorbidities, and other factors all influence the special needs of each patient, and three-dimensional (3D) printed medications have the potential to revolutionize the pharmaceutical business by providing individualized therapies. These supports provide the choice to alter the drug’s efficacy and safety. The capacity to manufacture very little of drugs with customized doses, forms, sizes, and release properties is the primary benefit of 3D printing technology. This method of producing drugs might make the idea of customized medications a reality for bettering patient care. Diverse three-dimensional printing methods have been developed to create innovative solids dosage forms....
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Posted by admin on Aug 31, 2024 in |
Herbal medicines, with their rich history of use, often face challenges in achieving optimal effectiveness due to low absorption rates and limited bioavailability of their phytoconstituents. While these constituents are typically water-soluble, their inability to penetrate lipid membranes compromises their efficacy. To overcome these limitations, integrating herbal drugs with nanotechnology has emerged as a promising approach. Nanoparticles offer a potential solution by enhancing the absorption, permeability, and retention of herbal extracts within the body. This augmentation can lead to improved potency while minimizing the required dosage and reducing side effects. Importantly, the utilization of nanotechnology does not disrupt normal physiological processes. The primary objective of this study is to systematically explore the application of nanotechnology in crafting herbal nano formulations aimed at various pharmacological activities. Through this investigation, we aim to elucidate how nanoparticles can synergize with herbal extracts to unlock their full therapeutic potential, paving the way for enhanced herbal medicine utilization in modern healthcare...
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Posted by admin on Aug 31, 2024 in |
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in general terms, along with the concepts of combinatorial libraries, methodologies and applications. This technique significantly lowering the cost involved in new drug research and increases the chances of finding new lead molecules. Most commonly used combinatorial techniques are solid phase synthesis, Parallel synthesis, mixed combinatorial synthesis and solution phase synthesis. Combinatorial chemistry is useful for the efficient detection of big molecules as well as the production of tiny molecules and peptides. The aim of this project is to give a fundamental overview of combinatorial chemistry, outlining the evolution of key methods and a few...
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Posted by admin on Aug 31, 2024 in |
An overview of the drug discovery and development process in brief helps scientists whose work could be important in deciding the process to properly design their research report for the successful translation of preclinical research to human subjects. The idea for the drug’s discovery and development may have come from a variety of sources, including the demands of the market at the time, clinical and scholarly research, the commercial environment, etc. In order to control the marketing of drugs, each pharmaceutical industry is required to abide by the laws, rules, and regulations of their respective nation. The majority of newly developed medications on the market today are synthetic. The process of developing new medications is expensive due to the significant expenses linked to research and development as well as clinical trials. Information regarding drugs, the development process, and regulating bodies in Europe, Japan, the USA, and India are provided in this...
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