Posted by admin on Apr 30, 2024 in |
The demand for Mouth Dissolving Tablet has been increasing for the last decade particularly in geriatric, peadiatric and patient with some sort of disabilities in swallowing. Mouth dissolving tablets are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopeia adopted the term Oro-dispersible tablet for MDTs. Mouth dissolving tablets are also known as Fast melting tablets. Oro-dispersible tablets, fast dissolving tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as a oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilization technologies, tablet molding method, sublimation techniques, spray drying techniques, direct compression method. It also reviews the patented technologies for fast dissolving tablets, advantages and disadvantages of different technologies for preparing fast disintegrating dosage form, future...
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Posted by admin on Apr 30, 2024 in |
In response to the increasing popularity and greater demand for medicinal plants, several conservation groups recommend cultivating wild medicinal plants. Green Tea is among the most ancient and popular therapeutic beverages worldwide. This product is made from the plant leaf called “Camellia sinensis.” It can be prepared as a drink, which can have many systemic health effects or an “extract” can be made from the leaves for medicine. Green tea contains thousands of bioactive ingredients, which are almost contributed by polyphenols, which play a key role in preventing and treating many diseases. This literature review aimed to illustrate the phytoconstituent and marketed products of the plant “Green...
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Posted by admin on Apr 30, 2024 in |
Diabetes Mellitus is characterized as metabolic chronic disease spreading all over the world ata high pace. Due to its speedily wide population spreading it is termed as 3rd most populated country in the world since the number of individuals diagnosed with diabetes is just behind population of China and India. To date treatment therapy concerning diabetes majorly responds to insulin-dependent mechanisms. A newer activity regarding renal glucose mechanism highlights a novel treatment to curtail diabetes. Filtered glucose gets transported through the kidney, when reaches proximal tubules further reabsorbed through sodium glucose co-transporter-2 [SGLT-2] and elevates blood glucose level. SGLT-2 inhibition provokes a new treatment for diabetes and Empagliflozin, a novel, potent SGLT-2 inhibitor class drug and compare to other drugs of this class, Empagliflozin exerts a favorable once-daily dose and negligible risk of hypoglycemia. On the other hand, Sitagliptin is a DPP-4 inhibitor and has a significant role in the improvement of activity of GLP-1 situated in the myocardium pathway, an incretin hormone which got released from intestinal L...
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Posted by admin on Mar 31, 2024 in |
Hepatitis B, Diabetes, Alcoholic and Non-alcoholic Fatty Liver Disease, Cholangiocarcinoma, Cholangioleiomyopathies, and other risk factors for hepatic illness are all becoming more harmful nowadays. In animals, the dysfunction of melatonin levels and an unbalanced circadian rhythm can control physiological processes and cellular mechanisms during periods of rest and activity. The Suprachiasmatic Nucleus (SCN) in the Hypothalamus of the Brain and Melatonin production in the pineal gland control circadian rhythms and clock gene expressions. The main purpose of the study is to summarise the most recent research on the molecular mechanisms underlying Circadian Rhythm, including the core clock genes and melatonin release, and their relationship to chronic liver diseases. Also covered were the future methods for studying Circadian Rhythm’s Chronopharmacological Aspects for the Treatment of Hepatic...
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Posted by admin on Mar 31, 2024 in |
Thespesia populnea Linn., a member of the Malvaceae family also known as Portia tree, a plant commonly found in coastal and tropical regions of India. Its therapeutic properties have been recognized in ayurvedic medicine, which has been validated by modern scientific research. This paper highlights the chemical constituents and pharmacological profile of Thespesia populnea. The plant has shown remarkable potential as an anti-inflammatory, antidiabetic, antimicrobial, antipsoriatic, antidiarrheal, anti-implantation, anticancer, and alzheimer’s disease management agent etc. Its extracts also exhibit a synergistic activity with oxytetracycline, a commonly used antibiotic. Additionally, the plant is used as a natural dye for various fabrics, a source of biodiesel and an anti-corrosive agent. Phytochemical analysis has exposed the presence of alkaloids, sesquiterpenoids, fatty acids, polysterol, glycosides and alkane in various extracts of the plant. These bioactive compounds are responsible for the diverse pharmacological activities exhibited by Thespesia populnea. The review provides advanced evidence to support the traditional knowledge of Thespesia populnea and highlights its potential as a source of novel drugs for various diseases....
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