Posted by admin on Jan 31, 2024 in |
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water solubility of drugs. Solid dispersions are one of the most successful strategies to enhance the oral bioavailability of poorly water-soluble drugs by reducing particle size and improving drug wettability. This article reviews various types of solid dispersion, and their preparation techniques. Some of the practical aspects to be considered for the preparation of solid dispersions are selection of carrier and methods of physicochemical characterization thorough study of nature of drug in solid dispersion etc. are discussed. At the end of the article commercialization of some solid dispersion and recent revival has been considered. This article gives scope for research in enhancement of solubility of poorly water-soluble...
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Posted by admin on Jan 31, 2024 in |
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Indole derivatives possess various biological activities, i.e., antiviral, antifungal, antidiabetic, anti-inflammatory, anticancer, antifertility, anti-HIV, antioxidant, antimicrobial, antitubercular, anticonvulsant, antimalarial, anticholinesterase activities, etc. which created interest among researchers to synthesize a variety of indole derivatives. This review focussed on recent developments of indole derivatives having different pharmacological profiles as well as different perspectives on how this indole moiety as a privileged structure may be exploited in the...
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Posted by admin on Jan 31, 2024 in |
Traditional medicine has been aware about and made use of “medicinal herbs,” for millennia. Numerous chemical compounds are produced by plants to serve a variety of purposes, including defence and protection against diseases and disorders. Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) are prevalent forms of DM, characterised by deficient insulin secretion (in T1DM) or impaired insulin action (in T2DM). Type 1 diabetes mellitus (T1DM) is typically identified in the paediatric and adolescent population, whereas type 2 diabetes mellitus (T2DM) is more prevalent among middle-aged and elderly individuals. The latter group often exhibits chronically elevated blood glucose levels due to lifestyle and dietary choices that are deemed detrimental to health. The black plum, or Eugenia jambolana Lam. (syn) Syzigium cumini (L.) skeels, is a medicinal plant widely used in various alternative Indian medical systems such as Ayurveda, Unani, and Homoeopathy. The utilisation of this plant has demonstrated efficacy in managing diabetes mellitus, mitigating inflammation, healing ulcers, and alleviating symptoms of diarrhoea. Preclinical studies have demonstrated...
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Posted by admin on Jan 31, 2024 in |
Now a day’s food materials are packaged and wrapped in paper that is the dangerous practice of wrapping, covering or processing foods with newspaper and printed recycled paper materials remains commonplace worldwide, as seen in the plethora of photographs in advertisements online or in magazines showing newspaper wrapped foods. The health hazard of ink contamination to foods and long-term contact with complex chemicals should always be considered because of the potentially diverse array of biological and toxicological effects. Polycyclic aromatic hydrocarbons inhibit the function of thyroid, adrenal and male reproductive system, like secreted hormonal imbalance due to this several disorders occurs in human body. However, proposed studies will be helpful to human health especially to thyroid, adrenal and male reproductive system deficiency caused by polycyclic aromatic hydrocarbons because we have avoided ink-based newspaper wrapped food materials to minimize the endocrine glands diseases. We will initiate systematic campaigns for generating awareness among all the stakeholders to discourage the use of newspapers for packing, serving and storing food items. Therefore, this...
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Posted by admin on Jan 31, 2024 in |
Cannabis sativa L. is an annual herbal plant of the family Cannabinaceae and abundant in nature. It is known locally as igbo, taba, blaze, joint, pot, dope, ganja, sensi, kpoli, weed, and morocco on the streets of Nigeria, and used as a medicinal plant for many centuries in many different parts of the world. Although native to Central Asia, Cannabis is now grown globally. Cannabis is the most abused plant worldwide, used for medical and recreational purposes. Recent studies have shown its efficacy in several disease conditions, including pain, sleeplessness, depression, and intractable epilepsy. The use, handling and cultivation of Cannabis sativa in Nigeria is illegal and backed by several laws. Despite the availability of these regulations and legislation, Nigeria is currently dealing with a drug abuse issue. After alcohol, cannabis is the most often used illicit/illegal substance in Nigeria, with a 10.8% estimated prevalence use rate. Cannabis use in Nigeria has no class distinction as it is used by both the rich and the poor, with Nigeria currently...
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