Posted by admin on Jun 30, 2024 in |
The increasing demand for natural polymers has fuelled substantial investment in research and development within the pharmaceutical and biotech sectors. Natural polymers, lauded for their biocompatibility, biodegradability, and safety, offer versatile advantages and among these, polysaccharides and proteins stand out. One class of natural polymers, gums, obtained primarily from plants, is gaining prominence in pharmaceuticals, biotechnology, and food industries. Notable examples include Xanthan gum, Guar gum, Locust bean gum (LBG), and Tara gum, all sharing the galactomannan compound at their core. LBG exhibits a range of physical and chemical properties that make it a valuable candidate for drug delivery systems. This natural biopolymer, with its unique characteristics, presents a compelling case for incorporation into oral drug delivery systems. The chemical composition of LBG makes it well-suited for interaction with other natural polymers. This interaction can lead to the development of novel drug delivery systems with controlled-release, improved solubility, and enhanced bioavailability. LBG’s compatibility with various natural polymers offers a wide array of possibilities for formulation enhancement. Pharmaceutical applications of...
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Posted by admin on May 31, 2024 in |
Medicinal plants usage has been continued since olden times for treatment of illness and various diseases internationally. They contain substances which have therapeutics activities and further study of these substances has led to discovery of new drugs. In present days, the medicinal plants play a significant role in the development of plant-based medicines. Myrica esculenta is a plant which belongs to family myricaceae and is found in foothill tracks of Eastern Himalayas, Meghalaya, Nepal, China and Pakistan. Myrica esculenta are rich in flavonoids, tannins, steroids, terpenes. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments and skin diseases and pharmacologically used as anti-bacterial, anti-inflammatory, anti-diabetic, anthelmintic, antioxidants, antipyretics, and wound healing. Research carried out using different in-vitro and in-vivo techniques of biological evaluation support most of these claims. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal...
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Posted by admin on May 31, 2024 in |
Schedule Y has been established under Drugs and Cosmetic Act 1940 and rule 1945 for the conduction of clinical trials. It is referred to fundamentals and guidelines for import and manufacture of original drugs for trade or for clinical trials. Schedule Y provides guidance for conducting various clinical trials in different fields of clinical research, controlling and regulating any new drug prior to their entry into the market. It includes the responsibilities of key authorities such as sponsors, investigators, and ethics committee) and year wise evolutions, as well as the evolution of these guidelines over the years as the review present (sponsor, investigator and ethics committee) and year wise evolution suggested by various authorities. In addition, different phase of clinical trials with their respective roles. This updated study demonstrates the Indian government’s strong commitment to the conduct of trials in India and safeguarding the interests of human subjects. The Suggestive consolidations for improving clinical trials may contribute significantly to strike balance between the interest of the subjects and the growth...
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Posted by admin on May 31, 2024 in |
Phytosterols, a subclass of steroids, have gained considerable attention in scientific research and nutrition due to their potential health benefits. This article presents an overview of phytosterols, encompassing their sources, chemistry, extraction methods, analytical techniques, and biological activities. Phytosterols, structurally resembling cholesterol, are found abundantly in plants, animals, and fungi. Their physiological roles include influencing membrane fluidity and acting as second messengers in signal transduction pathways. Incorporating phytosterol-rich foods into the diet has been linked to various health benefits, particularly in reducing cholesterol levels, as recognized by regulatory bodies like the European Food Safety Authority and the FDA. The article discusses various extraction methods for phytosterols, emphasizing the need for environmentally friendly approaches to minimize the use of organic solvents. Traditional techniques such as Soxhlet extraction are effective but pose health and environmental concerns, driving the exploration of alternative extraction technologies. Phytosterol chemistry, characterized by specific carbon atoms and side chains, is explored, highlighting their steroid structure and different forms in nature. Analytical methods such as gas chromatography (GC),...
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Posted by admin on May 31, 2024 in |
The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on the utilization of these drugs. Certain pharmaceuticals require a period of 30 to 60 minutes to reach equilibrium in maternal and fetal circulation, albeit at different concentrations and under varying conditions. Variables, including placental potency, dosage, maternal characteristics, drug efficacy, and gestational age at the time of exposure, contribute to the impact of drugs on the fetus. Notably, during the initial three weeks of pregnancy, a developing fetus is more susceptible than the mother. The National Institutes of Health (NIH) has documented spontaneous abortion, allergies, preeclampsia, gestational diabetes, hypertension, depression, and anxiety, as well as mild to severe functional or metabolic abnormalities as commonly reported complications during pregnancy. This review aims to ascertain the transplacental genotoxicity associated with medications employed...
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