Posted by admin on Nov 30, 2023 in |
Autism spectrum disorders (ASDs) refer to the group of neuropsychiatric disorders that alter neurodevelopment and mental function and are characterised by an extensive range of symptoms, including hyper-or hyposensitivity, repetitive behaviours, and impairments in social and academic functioning. Untangling the causation of ASD has been complicated, in part because distinct genetic abnormalities can result in both identical and distinctive traits that entirely fall within ASD. ASD can be triggered by hereditary and/or environmental causes. Studies in both experimental and clinical trials have revealed that the gut microbiome is altered in ASD patients. Due to its linkages to nutrition and the reciprocal relationship with the host, these changes affect the composition of the gut microbiota and also the metabolites they create. The gut-brain axis (GBA) mediates how the central nervous system (CNS) associated roles and behaviours are affected by psychobiotics, a unique family of probiotics that enhances not only gastrointestinal (GI) function but also anxiolytic and antidepressant activity. Psychobiotic use can enhance GI processes and ASD-related symptoms. New models for studying ASD...
Read More
Posted by admin on Oct 31, 2023 in |
Diabetic kidney disease (DKD) is the main reason for end-stage renal disease on a global scale. About 40% of developing diabetic kidney disease, which is the most common cause of chronic kidney diseases worldwide. Although ESRD may be the most complication of diabetics, as a result of their physical health and any co-morbidities they may have, such as obesity, hypertension, dyslipidemia, intrarenal vascular disease, renal ischemia, or age-related nephron loss, One-third of people with type 1 diabetes and at least half of people with type 2 diabetes will eventually develop renal dysfunction. CKD is present and is severe. Glomerular hyperfiltration, falling GFR, and finally, ESRD are parts of the diabetic kidney disease natural history. Diabetes-related complications can lead to diabetic kidney disease. Disturbances in glucose metabolism, hypertension, dyslipidemia, develop kidney disease. Controlling blood sugar levels, blood pressure, and renin-angiotensin-aldosterone system blockage are all part of intensive therapy for diabetic patients; For diabetic kidney damage to be postponed or prevented, glycemic management is crucial. Several glucose-lowering drugs are on the...
Read More
Posted by admin on Oct 31, 2023 in |
Since ancient times, natural products, especially plants have been utilized to treat variety of disorders, and an astounding number of contemporary medications have been created from them. All across the world, liver problems are prevalent. These conditions are only mildly handled traditionally; however, allopathic treatment always makes the situation worse when used to address more severe conditions. The current review offers summaries of plants (44 species from various families) with hepatoprotective qualities that may be discovered in literature sources from various databases and are properly categorized based on the parts utilized. Through the use of experimental animal models, all the plants were examined scientifically for their ability to protect the liver by testing certain parameters, such as liver indicators (AST, ALT, ALP, total protein content, albumin, and bilirubin), as well as through histological analysis, the hepatoprotective action was scientifically demonstrated. From the review, phytoconstituents such flavonoids, glycosides, terpenoids, and alkaloids are primarily responsible for medicinal plants’ hepatoprotective properties. It will be useful for the researchers to discover a field...
Read More
Posted by admin on Oct 31, 2023 in |
Diabetes is currently not well managed in the allopathic medical system. The dysfunction and damage to several organs, including as the blood vessels, heart, nerve fibres eyes, kidneys, and, neurons are chronic repercussions of long-term blood glucose elevations. There are many different therapy options available, but they frequently have negative side effects and cannot provide complete relief. The key to addressing these kinds of problems is to identify novel therapeutic targets and use them in conjunction with the present diabetes treatment approaches. Herbal plants are now being used by researchers to combat the negative impacts of currently available medications. When managing diabetes using conventional treatment. Herbal plants are now being used by researchers to combat the bad impacts of currently available medications. Therefore, it is essential to develop more modern, plant-based medicinal approaches that can be safer and more accessible. This study looked at the anti-diabetic effects of different Mooringa oleifera species parts, including the fruits, seeds, leaves, pods flowers, and stems. The resulting extract was administered to diabetic-induced...
Read More
Posted by admin on Oct 31, 2023 in |
Clinical trials (CTs) are carried out to investigate novel, patient-acceptable, and more effective interventional procedures. Specific regulatory criteria for conducting CTs are recommended by the country’s drug regulatory authority, and these guidelines are followed when conducting CTs. The USFDA oversees regulating CTs in the USA in accordance with the Federal Food, Drug, and Cosmetic Act’s 21 Code of Federal Regulations, Part 312 (CFR). According to the GCP Directive 2005/28/EC of the 8 April 2005 and the CT Directive 2001/20/EC of the European Parliament and of the Council of the 4 April 2001, they are under the control of the European Commission and EMA in the EU. Both the ICMR and the CDSCO (Schedule Y, D&C Act) have control over the Ethical Guidelines for Biomedical Research on Human Subjects. The European Commission’s objective of promoting an environment that is suitable to CTs within the EU is to be realised with the help of the Clinical Trials Regulation (CTR) (No. 536/2014). All interventional CTs involving medicines for human use that are...
Read More
