Posted by admin on Oct 31, 2023 in |
Dissolution is an authorized test used by Pharmacopoeias for assessing drug arrival of solid and semisolid measurement structures. The primary utilization of dissolution testing incorporates the biopharmaceutical portrayal of medication items as a device to guarantee reliable item quality and to predict in-vivo drug bioavailability. Dissolution testing was initially grown for solid orals; later on, its utilization was enlarged to an assortment of novel dose structures. Because of the intricacies in the medication conveyance of novel dose structures, there is a need to create changed dissolution testing strategies to describe the in-vitro arrival of these measurement structures. The article addresses the ongoing updates in dissolution testing strategies for ordinary and novel drug measurement structures and gives knowledge of potential choices in drug dissolution testing plans. This survey addresses all potential state-sanctioned test techniques expected to describe the dissolution properties of a wide assortment of measurement structures going from customary to novel...
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Posted by admin on Oct 31, 2023 in |
Cadmium (Cd) is one of the non-essential and highly toxic environmental pollutants. It causes serious environmental and agricultural problems. It ranks seventh on the list of the twenty most toxic metals. Dietary cadmium intake is much higher than the upper limit reported by FAO/WHO. Sources of environmental Cd contamination, soil factors affecting Cd uptake, Cd dynamics in the soil rhizosphere, uptake mechanisms, Cd transport and toxicity in plants. In crops, Cd toxicity reduces nutrient and water uptake and transport, increases oxidative damage, disrupts plant metabolism, and disrupts plant morphology and physiology. Factors effecting the uptake and translocation of Cd in plants are elaborated to understand the mechanism that contributes to its accumulation. Cadmium disturbs the function of chloroplasts by accumulating to higher levels in aerial parts. It inhibits the enzymes needed for chlorophyll biosynthesis as well as enzymes for carbon dioxide fixation Ribulose-1, 5-biphosphate carboxylase (RUBPCase) and phosphoenol pyruvate carboxylase (PEPCase). Using molecular techniques, including identification of QTLs, CRISPR/Cas9, and functional genomics, to amplify the adverse effects of Cd...
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Posted by admin on Oct 31, 2023 in |
One of the most important difficulties in contemporary medical biology is the creation of a cutting-edge, effective drug delivery system with a considerable improvement in its efficacy and increased therapeutic value. The advancement and development of innovative drug-delivery nanocarrier systems with accuracy and reduced side effects have been made possible by merging nanomaterial science with molecular and cellular biology. Over the past few years, the design and manufacture of nanocarriers using graphene oxide (GO) have grown quickly. Because of its amazing physicochemical features, GO has been widely exploited in efforts to create nanocarriers with high specificity, selectivity, biocompatibility, and minimal cytotoxicity. This review focuses on recent applications, synthesis, of GO-based nanocarriers, and advancements in enceinte drug delivery systems. Following a brief explanation of the principles and difficulties surrounding nanocarrier systems, we offer important illustrations of the transport of drugs and genes using GO. The assessment concludes with a few succinct observations on what is known currently and what the future may hold for nanocarrier delivery...
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Posted by admin on Oct 31, 2023 in |
India may have a potential in the Commonwealth of Independent States (CIS) region. Pharmaceuticals are difficult to register with the CIS region’s regulating organisation because of the turmoil among these countries. The CIS includes Russia, Ukraine, Kyrgyzstan, Uzbekistan, Tajikistan, Kazakhstan, Turkmenistan, Azerbaijan, Armenia, Belarus, Moldova, and Georgia. These call for various regulatory standards for drug registration. Based on the FDA’s recommendations, it will be problematic to have various policies in the same area- activity of exporters and producers; registration of the same product in various nations; work of manufacturers and exporters. The same documents cannot be used to implement CIS due to the lack of regulatory harmonisation. Manufacturers and exporters must submit various country-specific documents to reach these markets since these nations adhere to a country-specific document format. Both Ukraine and Kazakhstan have enacted stringent regulations and are awaiting United States Food and Drug Administration (USFDA) – level document certification. The Gulf Cooperation Council (GCC) is regarded as a “growing industry both in terms of trade agreements and drug...
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Posted by admin on Oct 31, 2023 in |
Stem cell-based therapeutics have considerable potential to treat a variety of illnesses that are now incurable. Because of recent scientific advancements, the area of applied medical research has taken a positive turn, and stem cell-based techniques have moved considerably closer to clinical applications. Since their discovery, stem cells have revolutionized medical research and dramatically altered our understanding of human biology. Understanding of the evolution of the human body and how it fixes itself after harm has been greatly increased. This is why the use of stem cells in human applications has expanded dramatically. This has boosted interest in stem cell therapy. With a genuine interest in long-term quality research into critical problems, some of which are described below, it will be intriguing to deliver therapies based on stem cells to patients with terminal diseases and impairments in order to assist them significantly enhance their quality of life. Stem cell treatments have emerged as a promising and advanced area in scientific study in recent years. This advancement has increased the bar...
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