Posted by admin on Dec 31, 2023 in |
Pharmacological research is a complex and challenging field that seeks to understand the effects of drugs on living organisms. In-vivo and ex-vivo methods are two of the most essential tools used in pharmacological research, each with its own advantages and disadvantages. In-vivo methods involve testing drugs in living organisms, typically animals. This type of research can provide valuable information about the effects of drugs on the entire organism, including its metabolism, distribution, and elimination. However, in-vivo research can be expensive, time-consuming, and ethically challenging. Ex-vivo methods involve testing drugs on isolated tissues or cells. This type of research can provide more detailed information about the mechanisms of action of drugs, but it needs to consider the drug’s effects on the entire organism. The use of in-vivo and Ex-vivo methods together can provide a complete understanding of the effects of drugs. In-vivo methods can be used to identify potential new drugs, while ex-vivo methods can be used to study the mechanisms of action of drugs and to optimize their dosage...
Read More
Posted by admin on Dec 31, 2023 in |
The herbal drugs derived from plant sources are used in traditional pharmacopeia and also act as precursor in lab to synthesize medicines at large scale. Acanthaceae is a large family comprising of various medicinally valuable species. In traditional use, the leaves of this family are commonly recognized to alleviate the poisonous bites of reptiles and insects and whole plants for the treatment of external wounds and ulcers. The pharmacological effects evaluated from various species of this family are antibacterial, antifungal, antipyretic, hepatoprotective, anti-inflammatory, cytotoxic, antioxidant, anti-platelet aggression and insecticidal activities. The phytochemicals reported from this family are mainly flavonoids, alkaloids, lignans, benzonoids, fatty acids, terpenoids, tannins and a few triterpenoid saponins. In the present study two genera namely Blepharis and Lepidagathis of the family Acanthaceae were selected with the focus on their traditional use, chemical constituents, and pharmacological activities. Various pharmacological experiments have verified their practice in traditional use and species of both the genera emerged as good source of herbal medicines. However, uncharacterized crude extract was employed in...
Read More
Posted by admin on Dec 31, 2023 in |
Biopharmaceutical technologies used to create biodegradable materials from biological agents fall within a broad spectrum. The production of bioproducts has grown cleaner and more dependable with the adoption of novel biotechnological approaches. The original study objective was to investigate the legal difficulties surrounding the purchase and sale of biological as well as pharmaceutical products. The production, advancement, and application of biosimilars in medical care are all governed by a legal regime. Guidelines are collections of requirements that producers must adhere to guarantee the efficacy and effectiveness of pharmaceuticals as well as the highest possible consumer security against newly produced goods. Control of biopharmaceuticals entails a comprehensive strategic plan to guarantee superior levels of security and performance. The research concentrates mainly on the trade in and out of drugs from Switzerland, Brazil, and India. International drug manufacturers are now given a stronger legal base on which to introduce novel drugs to the marketplace. This licensing process for new pharmaceuticals can take a year or longer because the healthcare regulatory structure...
Read More
Posted by admin on Dec 31, 2023 in |
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the lattice structure, which result from the loss of oxygen and/or its electrons during redox processes, alternating between CeO2 and CeO2 x. Being a mature engineered nanoparticle with a variety of industrial applications, it was recently discovered to have multi-enzyme, including reactive oxygen species oxidase, catalase, and oxidase, mimetic properties that produce a variety of biological effects, including being potentially anti – oxidants towards almost all toxic and harmful intracellular reactive oxygen species. In biological domains such as bioanalysis, biomedicine, drug carriers, and bioscaffolding, nanoceria has emerged as an intriguing and valuable material. This review paper gives a thorough overview to nanoceria nanoparticles and their manufacture, multi-enzyme-like activity, prospective...
Read More
Posted by admin on Dec 31, 2023 in |
Dry eye disease (DED) is one of the most common conditions in today’s digitalized society. DED is associated with decreased tear production, an unstable tear film, and ocular inflammation. Due to the COVID-19 pandemic, the use of digital screens (computers, laptops or smartphones) for work, study or entertainment has increased. As a result, the constant use of digital screens affects the eyes and makes everyone, including youth in the modern era, more susceptible to dry eye disease (DED). Alterations in mucin production are considered one of the most important causes contributing to dry eye disease. MUC5AC, a gel-forming mucin, acts as a surface active agent on the ocular surface and facilitates an evenly distributed tear film that moisturizes the conjunctival epithelium. The prolonged use of artificial tears and other allopathic medications results in specific adverse effects. Therefore, dietary nutrient intake and nutraceutical supplementation with active ingredients can be considered a safe and effective therapy for the treatment of dry eye disease. In conclusion, this review focused on some nutrients...
Read More
