Posted by admin on Aug 31, 2023 in |
An overview of the neurodevelopmental disorder ADHD (attention deficit hyperactivity disorder), its consequences, and details on the brain regions impacted by ADHD are the driving forces behind this review. The hereditary basis of ADHD has been investigated. Throughout the investigation, numerous reviews and research publications were compared and examined. The themes covered in this article are (a) ADHD as well as its symptoms (b) the complexity of the brain regions affected in ADHD patients (c) and (d) linkage analysis for researching the genes of ADHD. The brain’s structure, development, and functioning will alter, according to review analysis results. The main brain areas involved include the cerebellum, parietal, Prefrontal and frontal lobes. According to the study, the thickness of the cerebellum will diminish, and the anterior striatal region will be most negatively impacted. There isn’t much proof that ADHD is inherited, although a few experts have suggested that there may be a connection between siblings’ ADHD and their DNA. For a complete understanding of the condition, a great deal more...
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Posted by admin on Aug 31, 2023 in |
Rosuvastatin is a widely used lipid-lowering medication that belongs to the class of “Statins” whereas Teneligiptin is a novel potent drug that belongs to the class of “DPP-4 inhibitors” which is used for the treatment of Type 2 Diabetes mellitus. The FDA recently approved the combination of these two drugs in 2021 since it proved to be highly effective for treating dyslipidemia associated with Type 2 Diabetes mellitus. Forced degradation studies have been performed on Rosuvastatin and Teneligliptin separately using various analytical techniques such as RP-HPLC, UV, RP-UFLC, RP-UPLC, UHPLC, HPTLC and TLC. Characterization of the degradation products generated during various stress conditions is also performed using various sophisticated techniques such as UPLC, LC/MS/MS, NMR, and FT-IR. These degradants can cause many adverse effects, such as carcinogenicity, mutagenicity, neurotoxicity, hepatotoxicity, skin sensitization, respiratory sensitization, etc. So, identifying and characterizing these degradation products will be very useful for their metabolic studies and in-silico toxicity assessment. In-silico toxicity studies are very helpful in predicting the toxic potential of these degradants, and...
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Posted by admin on Aug 31, 2023 in |
Drug resistance in bacterial strains has often been detected in the last two decades and is increasing yearly. Novel survival mechanisms and over-the-counter antibiotic availability (OTC) complicated this issue, especially in relation to the Asian continent. Resistance to drug/antibiotic is multifactorial viz, plasmid encoding drug resistance, pumping the drug out by pumping mechanism from the bacterial cell, degradation of antibiotic by using enzymes such as β-lactamases, carbapenemase and others. Bacterial drug resistance is a global threat, and the discovery of novel antibiotics to address this challenge has not kept pace. Critical appraisal and drug development timelines in clinical phases made the task costly and tedious. Global pharmaceutical companies have withdrawn their attention, and only a limited number of companies are doing research and development in this field. The present review discusses the current scenario worldwide and introduces one health plan’s role in terms of the discovery of novel drugs and increased drug...
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Posted by admin on Aug 31, 2023 in |
Microbes are widespread and have been studied widely in recent years. Disease-causing microbes can also be called pathogens, germs, or bugs. These microbes are responsible for causing infectious diseases. Microbes are mediators in almost all ecosystem processes and act as a global pivotal game changer in various ecological activities. The therapeutic outcome with antimicrobial drugs depends totally on the selection of antimicrobial drugs. The choice of antimicrobial drugs depends on causative agents, patient factors, and clinical pharmacology of antimicrobial agents. The current review discusses how microbes can enter the human body through different sites and how antimicrobial drugs help cure various infectious diseases. Along with the same, the current review also represents how antimicrobial drugs affect the viability of microorganisms. The article also incorporates the prophylactic use of antimicrobial drugs. The main objective of the current review article is to give detailed knowledge about single, binary and tertiary combinations of antimicrobial drugs, analytical methods, and patent search of these...
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Posted by admin on Aug 31, 2023 in |
Despite different therapy, such as chemotherapy, for cancer, it has become the leading cause of death globally. This boosts the researcher for searching for a new lead molecule with a simple structure and maximum potency with little adverse effect. In recent years, 1,3,4-thiadiazole moiety attracted the attention of scientists for the development of novel compounds. The different articles reported that 1,3,4-thiazole derivatives have to exhibit various biological activities like antiviral, antitumor, antibacterial, antifungal, anti-inflammatory, antidepressant, and CNS depressant activities, etc. This review is tempted to highlight the detailed synthetic strategy and biological activities of 1,3,4-thiazole moiety and draw attention towards future development and drug...
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