Posted by admin on Aug 31, 2023 in |
Hypertension, also known as high blood pressure, occurs when the force of blood against the artery walls is excessively high the force of blood against the artery wall is too high. Hypertension is a very common disorder, particularly in past middle age. For improvement activity of hypertension, Azelnidipine and Telmisartan are newer combination in the market which is effective in hypertension. This combination was developed to improve medication for stage II hypertension. Azelnidipine is a Calcium channel blocker, and Telmisartan is an Angiotensin II receptor blocker. This review provides information about different analytical methods for estimating Azelnidipine and Telmisartan individually or in combination with other drugs, such as UV spectrophotometry, HPTLC, HPLC, and LC-MS. All reported methods were found to be simple, accurate, economical, precise, and reproducible. This review focuses on the recent analytical method development of Azelnidipine and Telmisartan in their combined dosage form. It also includes a stability-indicating analytical method for determining Azelnidipine and...
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Posted by admin on Aug 31, 2023 in |
N. sativa (black cumin seed) is popularly known for its medicinal significance such as Anticancer, Antioxidant, Anti-microbial, Anti-inflammatory, Anti-ulcer, Anti-parasitic, Anti-histamine, Analgesic, for skin rashes, hair treatment and also used as a flavoring agent. Recent reports reveal that the Nigella sativa seeds exhibit a potent effect on the Covid-19 virus. Further, N. sativa seed can be used to reduce weight as well as increase digestion. In this manuscript, the recent medicinal updates are highlighted. Finally, this review may attract the young researcher to further design and development of the...
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Posted by admin on Aug 31, 2023 in |
Gouty arthritis, an inflammatory joint disease, occurs due to the accumulation of Monosodium Urate (MSU) crystals in the joints, mainly at the metatarsophalangeal joints of the big toe. At present, the incidence and prevalence of gout are increasing globally. The various risk factors are responsible for the development of gouty arthritis, including nonmodifiable, modifiable, and genetic factors. Under physiological conditions, the purine undergoes a catabolic pathway to produce the uric acid end product excreted from the body using various uric acid transporters. The overproduction or under-excretion of uric acid leads to the pathophysiology of hyperuricemia and promotes the MSU crystals formation and deposition in joints to trigger inflammation by releasing inflammatory mediators in gouty arthritis. If chronic gout has been left untreated, the pain worsens and eventually causes cartilage degradation, bone erosion, and urolithiasis. The research studies of the antigout activity of the various secondary metabolites are manifested in this review. The inflammatory pathways involved in gouty arthritis development are being discussed to find a new therapeutic target to...
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Posted by admin on Aug 31, 2023 in |
An overview of the neurodevelopmental disorder ADHD (attention deficit hyperactivity disorder), its consequences, and details on the brain regions impacted by ADHD are the driving forces behind this review. The hereditary basis of ADHD has been investigated. Throughout the investigation, numerous reviews and research publications were compared and examined. The themes covered in this article are (a) ADHD as well as its symptoms (b) the complexity of the brain regions affected in ADHD patients (c) and (d) linkage analysis for researching the genes of ADHD. The brain’s structure, development, and functioning will alter, according to review analysis results. The main brain areas involved include the cerebellum, parietal, Prefrontal and frontal lobes. According to the study, the thickness of the cerebellum will diminish, and the anterior striatal region will be most negatively impacted. There isn’t much proof that ADHD is inherited, although a few experts have suggested that there may be a connection between siblings’ ADHD and their DNA. For a complete understanding of the condition, a great deal more...
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Posted by admin on Aug 31, 2023 in |
Rosuvastatin is a widely used lipid-lowering medication that belongs to the class of “Statins” whereas Teneligiptin is a novel potent drug that belongs to the class of “DPP-4 inhibitors” which is used for the treatment of Type 2 Diabetes mellitus. The FDA recently approved the combination of these two drugs in 2021 since it proved to be highly effective for treating dyslipidemia associated with Type 2 Diabetes mellitus. Forced degradation studies have been performed on Rosuvastatin and Teneligliptin separately using various analytical techniques such as RP-HPLC, UV, RP-UFLC, RP-UPLC, UHPLC, HPTLC and TLC. Characterization of the degradation products generated during various stress conditions is also performed using various sophisticated techniques such as UPLC, LC/MS/MS, NMR, and FT-IR. These degradants can cause many adverse effects, such as carcinogenicity, mutagenicity, neurotoxicity, hepatotoxicity, skin sensitization, respiratory sensitization, etc. So, identifying and characterizing these degradation products will be very useful for their metabolic studies and in-silico toxicity assessment. In-silico toxicity studies are very helpful in predicting the toxic potential of these degradants, and...
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