Posted by admin on May 31, 2023 in |
The global pharmaceutical sector is in vital need of both Innovative technology for solutions and basic science, allowing the production of highly engineered drug products. Commercial-level manufacturing of Complex drug delivery systems utilizing current technologies is challenging. Work within the pharmaceutical trade has been restricted for an extended time to the analysis and development of the latest active compounds; in the meantime, the structure of the assembly, dominated by batch-wise technologies, has not been modified until now. This review covers vital components of producing sciences, starting with risk management ways and design of experiments (DoE) techniques. Experimental techniques ought to, wherever attainable, be supported by process approaches. Thereupon regard, state-of-art mechanistic method modeling techniques square measure represented intimately. Implementing materials science tools paves the thanks for the molecular-based process of future Drug delivery systems. A pic of a number of the prevailing tools is bestowed. This review addresses fundamental tools for increased process understanding and perspective on future process...
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Posted by admin on May 31, 2023 in |
Passiflora foetida, commonly known as stinking passion flower has been used as traditional medicine in treating diseases such as throat infection, giddiness, liver disorder, diarrhea, tumor, nervous disorder, anxiety; sleep disorders, skin infections, hysteria and asthma. In addition, P. foetida has been reported to have potential antioxidant, anti-inflammatory, antiepileptic, anti hyperglycemic, cardio protective, anti-diarrheal, and anti-cancer properties. Metabolites isolated from this plant are mainly flavonoids, polysaccharides, α-pyrones and cyanohydrins. The compounds have been isolated from the leaves, stems, seeds, resins and fruits. The stems of P. foetida have high cellulose content. The leaves and fruits of Passiflora foetida have high nutritional value that they find use as herbal tea, tablets and nutritional powders. Vitexin was quantified by a high-performance thin-layer chromatographic technique. These compounds tend to have diverse biological properties. This review article highlights the secondary metabolites, quantification of phytochemicals, proximate parameters, chemical constituents their activities and...
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Posted by admin on May 31, 2023 in |
A category of illnesses known as neurodevelopmental disorders is predominantly linked to neurodevelopmental dysfunctions. The two most prevalent neurodevelopmental disorders, “Attention Deficit/Hyperactivity Disorders (ADHD)” as well as“Autism Spectrum Disorders (ASD)”, affect both humans and lower-class species like rats, mice and zebra fish. The purpose of this review is to identify the behavioral changes brought on by certain Neurodevelopmental disorders-Risk genes, such as CHD8, SHANK3, LPHN3, SLC6A3, etc., and to summarize their genetic screening and epidemiological researches, which directed various neurodevelopmental disorders in various organisms brought on by the interaction of genetic and environmental factors, as well as their genetic screening, which can be used to identify those diseases in humans by this orthologous gene that are present in humans. The majority of genes linked to neurodevelopment disorders were shown to have an excess of de novo mutations (DNMs), but case-control mutation burden research has not been able to prove their importance. We could identify the behavioral anomalies caused by these genes in different species for the development of neuropsychotic...
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Posted by admin on May 31, 2023 in |
Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD’s is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globally. There is hence a need of research of new molecules with improved therapeutics. Herbal medications have been utilized to treat cardiovascular diseases for many years around the world. The advancement of herbal nanotechnology in the field of CVDs has been shown to have astounding benefits over herbal crude drug formulations or herbal extracts, including better solubility, bioavailability, toxicity protection, pharmacological activity augmentation, dose reduction, and stability. This paper discusses the traditional herbal drugs and the herbal formulations, specifically herbal nanoparticles (NPs), for the treatment of CVDs and their...
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Posted by admin on May 31, 2023 in |
The new Covid-19 virus has reported deaths of around 1 million within about half a year. It has also led to high financial and social crises worldwide. Recent research has been performed to identify suitable treatment procedures. Steps have been taken to develop complicated, costly, and time-consuming vaccines. Viruses are highly potential to develop into perilous diseases. Over 165 vaccines were developed, and 45 are under clinical trials. The cost to manufacture and internationally deploy an efficacious COVID-19 vaccine will be vast, and the process will be at risk of politicization. Even though few countries may deploy COVID-19 vaccines based on the safety and immunogenicity information alone, vaccine development aims to obtain direct proof of vaccine efficacy for protection against SARS-CoV-2 infection. In this review, we have focused on the latest developments in COVID-19 and have sought to resolve the process and present development efforts of the vaccine in progress. Furthermore focused on the potential strategies in optimizing the COVID-19...
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