Posted by admin on May 31, 2023 in |
Tuberculosis is a very serious infectious disease that can lead to death if the person does not take medicine on time. This disease can be spread easily, but it is not mandatory that tuberculosis bacteria will attack suddenly. Still, when the immunity decreases for other reasons, then it will be an attack on health. Before this century, tuberculosis was known as a non-treated disease, but now most drugs are available for treating and curing tuberculosis. This present review provides an overview of the disease and the treatment of...
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Posted by admin on May 31, 2023 in |
AIM: This review aims to analyze the appropriateness of surgical antimicrobial prophylaxis in obstetrics and gynecology from 2015 to June 2022. Methodology: The review includes interventional, prospective and retrospective observational studies and surveys based on compliance with surgical antibiotic prophylaxis use concerning standard surgical antimicrobial prophylaxis (SAP) guidelines for gynecological and obstetrics surgeries from a web search of PubMed and Google Scholar from the year of 2015 to June 2022. Results: The review describes 33 studies focused on the appropriate usage of surgical prophylactic antibiotics. The majority of the studies revealed excessive and inappropriate use, and the compliance is far below the recommended guidelines, especially in terms of duration which is followed by the selection and time of administration of antibiotics. Conclusion: The majority of the studies analyzed in this review indicated a remarkable rate of inappropriateness, which may contribute to antimicrobial resistance (AMR), which raises the risk of SSI exacerbated by resistant bacteria followed by prolonged hospitalization and increased mortality. There is evidence that pharmacist intervention promotes the...
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Posted by admin on May 31, 2023 in |
This research primarily focuses on the process and impact of marketing authorizations, import, and export of COVID-19 vaccines in India and the United States. Pharmaceutical firms now have great legal grounds in India and the United States for vaccine manufacture and distribution. In this pandemic, the regulatory authority of India CDSCO and the US FDA updated the guidelines to provide approval for vaccines in less than a month through emergency use authorization. The Indian medical regulatory system and the USFDA have made it easier for COVID-19 vaccines to obtain clearance for commercialization. These new rules have made pharmaceutical companies easily get their vaccines to users. In today’s competitive world, shortening the time to launch a product is considered to company’s success. All pharmaceutical manufacturers/importers, regulatory, preclinical, formulation scientists, and clinical trial professionals who are directly or indirectly engaged in the covid-19 registration process will benefit from this study. We require expertise and broad views to properly handle the regulatory process for vaccination licensure in India and the United States...
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Posted by admin on May 31, 2023 in |
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grapes are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins, in addition to abundant quantities of gallic acid, p-coumaric, caffeic and ferulic acids etc. also present. Roots contain resveratrol, vitisins A & B and other stilbenoid compounds. Leaves of grapes include gallocatechin, catechins, procyanidins, epicatechins, hydroxybenzoic acid, syringic acid and coumarin. Grapes are rich sources of flavonoids and contain monomers, dimers, trimers, oligomers and polymers. The monomeric compounds includes (+)-catechins, (-)-epicatechin, and epicatechin-3-O-gallate. Grapes have pharmacological activities, like anti-inflammatory, antidiabetic, antioxidant, anti-aging, anti-cataract, antibacterial, antifungal, antiacne, antiobesity, antispasmodic, spasmolytic, anti-virus, wound-healing, antihypertension and antiplatelet and antihyperpigmentation. Studies have reported that grapefruit exhibit a broad spectrum of pharmacological properties against Alzheimer, tumor, leishmanial, Low-Density Lipoprotein, viral, oxidative stress, and had hepatoprotective activity....
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Posted by admin on May 31, 2023 in |
Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 first discovered isatin in 1840 as an oxidation product of indigo dye for nitric acid and chromic acid. Isatin is one of the most important heterocyclic compounds. For example, Schiff foundations of isatin are used for their medicinal properties. This review understands a variety of synthetic methods in particular, sandmeyer synthesis, stolle synthesis, and gassman synthesis isatin synthesis. This review reports some of the biological applications of Isatin derivatives such as anticancer, antiviral, antifungal, antioxidant, etc. From these studies, Isatin was established as a promising candidate for further research and investigation in a number of...
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