Posted by admin on Aug 31, 2023 in |
Drug resistance in bacterial strains has often been detected in the last two decades and is increasing yearly. Novel survival mechanisms and over-the-counter antibiotic availability (OTC) complicated this issue, especially in relation to the Asian continent. Resistance to drug/antibiotic is multifactorial viz, plasmid encoding drug resistance, pumping the drug out by pumping mechanism from the bacterial cell, degradation of antibiotic by using enzymes such as β-lactamases, carbapenemase and others. Bacterial drug resistance is a global threat, and the discovery of novel antibiotics to address this challenge has not kept pace. Critical appraisal and drug development timelines in clinical phases made the task costly and tedious. Global pharmaceutical companies have withdrawn their attention, and only a limited number of companies are doing research and development in this field. The present review discusses the current scenario worldwide and introduces one health plan’s role in terms of the discovery of novel drugs and increased drug...
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Posted by admin on Aug 31, 2023 in |
Microbes are widespread and have been studied widely in recent years. Disease-causing microbes can also be called pathogens, germs, or bugs. These microbes are responsible for causing infectious diseases. Microbes are mediators in almost all ecosystem processes and act as a global pivotal game changer in various ecological activities. The therapeutic outcome with antimicrobial drugs depends totally on the selection of antimicrobial drugs. The choice of antimicrobial drugs depends on causative agents, patient factors, and clinical pharmacology of antimicrobial agents. The current review discusses how microbes can enter the human body through different sites and how antimicrobial drugs help cure various infectious diseases. Along with the same, the current review also represents how antimicrobial drugs affect the viability of microorganisms. The article also incorporates the prophylactic use of antimicrobial drugs. The main objective of the current review article is to give detailed knowledge about single, binary and tertiary combinations of antimicrobial drugs, analytical methods, and patent search of these...
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Posted by admin on Aug 31, 2023 in |
Despite different therapy, such as chemotherapy, for cancer, it has become the leading cause of death globally. This boosts the researcher for searching for a new lead molecule with a simple structure and maximum potency with little adverse effect. In recent years, 1,3,4-thiadiazole moiety attracted the attention of scientists for the development of novel compounds. The different articles reported that 1,3,4-thiazole derivatives have to exhibit various biological activities like antiviral, antitumor, antibacterial, antifungal, anti-inflammatory, antidepressant, and CNS depressant activities, etc. This review is tempted to highlight the detailed synthetic strategy and biological activities of 1,3,4-thiazole moiety and draw attention towards future development and drug...
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Posted by admin on Aug 31, 2023 in |
Given their well-known lack of side effects in comparison to pharmaceuticals, natural materials with medical potential are rising in prominence in clinical research. Since the dawn of civilization, humans have relied on plants as a vital resource for healing. Medicines, health aids, pharmaceuticals, dietary supplements, cosmetics and other similar items derived from plants are becoming more popular. In this article, the chemical components and pharmacological effects of Tinospora cordifolia are described. “Guduchi,” a popular name for the plant T. cordifolia, has a long history of use in traditional Ayurvedic medicine. T. cordifolia, most often known as guduchi, is a prominent medicinal plant found across the tropics. The therapeutic benefits of this method are well recognized internationally. The advantages it has for your diet are less well-known. Native Indians and other Indians have long included guduchi [T. cordifolia (Willd.) Hook. F. Thoms] in their diets. It is also recommended for use in Ayurvedic diets. Interest in the plant has surged recently due to the identification of active components from the...
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Posted by admin on Aug 31, 2023 in |
Male reproduction is controlled and coordinated by endocrine factors and therefore, even minute changes can able to interfere with the male fertility. Accumulation of data have shown that the humans are exposed to chemicals that can able to interfere with endocrine factors. Interestingly, published reports have shown that the continuous exposure to such chemicals occurs mainly due to their wide usage in a variety of personal care and daily products such as plastics, food, water, fertilizers, textiles, shampoos, toys and pharma drugs etc. In view of ongoing interest in exposure of humans to such agents and compromised male fertility, there is a major concern and attention towards the endocrine disrupting chemicals among the public, endocrinologists, andrologists and scientific community. These chemicals interfere with the endocrine functions via mimicking their structure, blocking the hormone receptor and/or function of genes and proteins that facilitate normal spermatogenesis and testosterone biosynthesis. The present review provides an overview of endocrine disrupting chemicals on male reproductive health with a special focus on thyroid hormone disrupting chemicals....
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