Posted by admin on May 31, 2023 in |
Using plant extracts to synthesize metal nanoparticles is one of the easiest, most convenient, cost-effective, and ecologically acceptable ways of avoiding hazardous chemicals. As a result, many environmentally acceptable methods for the fast production of silver nanoparticles utilizing aqueous extracts of plant components such as leaves, bark, and roots have been described in recent years. This study highlights and expands on recent discoveries in the green production of silver nanoparticles (AgNPs) utilizing various plant extracts and their prospective uses as antimicrobial agents. A systematic in-depth discussion on the possible influence of phytochemicals and their concentrations in plant extracts, extraction solvent, and extraction temperature, as well as reaction temperature, pH, reaction time, and precursor concentration. Extensive details of the probable mechanism of AgNPs’ interaction with microbe cell walls, which leads to cell death and strong antibacterial activity, have also been developed. Furthermore, even though chemical techniques for shape-controlled synthesis are well-known, regulating the shape of biosynthesized AgNPs has numerous beneficial impacts on its...
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Posted by admin on May 31, 2023 in |
Coronavirus disease 2019 (COVID-19) pandemic has emerged as a major healthcare problem and has posed a great challenge to our existing healthcare facilities. Treatment of COVID-19 has been primarily based on repurposed drugs, drugs approved under emergency authorization or other options which are not thoroughly evaluated in patients with COVID-19, hence, lacking an adequate data on safety and efficacy. Public awareness and education regarding the potential benefits and safety concerns of the available therapeutic/prophylactic options are crucial to avoid ethical and medicolegal issues. Fundraising and global partnership are required to raise the research on potential older drugs likely to be repurposed, along with novel treatment options for COVID-19. A global effort is required to ensure the availability, distribution, and safer administration of COVID-19 vaccines. A rational and ethical approach is required to manage the patients with COVID-19. Equitable access to COVID-19 vaccines should be a priority to end this pandemic. In this review, we have focused on concerns regarding ethics and rational medicine use in view of the available...
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Posted by admin on Apr 30, 2023 in |
Introduction: The micro particles and development in the area of micro particles analysis are discussed in this article. Areas Covered: Micro particles are a unique drug carrier method that provides an effective therapeutic alternative to single-unit dose forms that are either traditional or rapid release. Micro particles are produced by filling them with firm gelatin or compressing them immediately. When compared to traditional dosage forms, micro particles manufactured using various types of technologies vary their performance and administration of the dosage form. Micro particles have been tested using in-vitro release techniques like dialysis membrane sacs, and USP equipment IV. According to comparisons of these techniques, USP apparatus IV is the preferred method right now. Accelerated in-vitro release assays were created to reduce the amount of time required for quality control testing. To reduce the necessity for in-vivo performance analysis, in-vitro and in-vivo correlation using real-time and accelerated release data have been produced. Storage stability studies have been carried out to see how different environmental conditions affect microsphere quality over...
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Posted by admin on Apr 30, 2023 in |
Favipiravir is, an antiviral agent, used to treat diseases caused by RNA viruses like Ebola virus, SARS-CoV-2, Influenza virus, Polio measles etc. The prodrug Favipiravir enters the infected cells through endocytosis and undergo metabolism to become an active drug. An active form of Favipiravir selectively targets the catalytic domain of RNA-dependent RNA polymerase and then interrupts the nucleotide incorporation process during viral RNA replication. This dysregulation of viral RNA replication results in mutations where the replacement of guanine by adenine and cytosine by thymine occurs. This ultimately induces destructive mutagenesis in RNA viruses. Currently, Favipiravir is available in tablet and intravenous dosage forms. The following analytical methods have been carried over for Favipiravir: UV, HPLC, LC-MS/MS, Spectrofluorometric method, and HPTLC-densitometric techniques are reported as per literature. The present paper illustrates the review of analytical methods which involve the estimation of Favipiravir in bulk or dosage form. The review also describes the scope and limitations of many published analytical methods for the analysis of Favipiravir. This detailed review article will...
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Posted by admin on Apr 30, 2023 in |
A wound is described as a break in a tissue’s cellular and anatomic continuity. A wound is a cellular, anatomical, and functional disturbance of living tissue induced by physical, chemical, electrical, or microbiological threats to the tissue. Wound healing is a multi-step process involving injured tissue regeneration or restoration. The typical wound-healing response is a coordinated series of processes that starts with an injury. Wound healing is a series of interconnected cellular and biochemical activities that result in restoring structural and functional integrity and re-establishing strength in wounded tissues. This study includes a review of plants with wound-healing activities found via ethnobotanical and folklore medicinal surveys. This article discusses the wound-healing capabilities of plants, as well as their botanical names, common names, families, parts utilized, and references, all of which might assist researchers to design novel wound-healing formulations for human...
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