Posted by admin on Apr 30, 2023 in |
Withania coagulans, commonly known as Rishyagandha in Sanskrit and Paneer phool in Hindi, is a plant in the Solanaceae or nightshade family, native to Afghanistan, Pakistan and the Indian subcontinent. Within the genus Withania, W. somnifera and W. coagulans are economically significant and are cultivated in several regions for their use in Ayurveda. Roots of W. somnifera have been known since ancient times for their use as Rasayana for the overall wellbeing of humanity. Withania coagulans fruit, though not as popular, has earned its medicinal importance because of its recently claimed use in diabetes. The antidiabetic activity of the plant is attributed to several reported phytoconstituents ranging from steroidal lactones like withanolides and withaferins to coagulonides and withacoagulins etc. The plant has also been reported to possess a wide range of pharmacological activities like antidiabetic, anticancer, immunomodulatory, hepatoprotective, neuroprotective, anti-inflammatory and many more. Though from the well-appreciated Withania family, the plant Withania coagulans, could attract less attention from the researchers. Hence, this review article aims to highlight the recent findings on the chemical and pharmacological potential of Withania coagulans, aiming to...
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Posted by admin on Apr 30, 2023 in |
Autoimmune thyroid disease triggers because of T cells attack in the immune system (in the thyroid gland). AITD mainly comprises of two types- ‘Hashimoto’s thyroiditis’ (hypothyroidism) & ‘Grave’s Disease’ (thyrotoxicosis). India has ‘42 million’ people groups experiencing thyroid disease, likewise it has perceived that in contrast with men 80% women affect more from immune system thyroid disease. The attentiveness of Autoimmune hyperthyroidism accounts from 3·0 to 7·5%, hypothyroidism accounts for 0·9%. Genetic Susceptibility, Sex Steroids, Stress, Pregnancy, Radiation Exposure, ‘Thyroid Peroxidase Antibodies (TPO), ‘Thyroglobulin Antibodies’ (TG), B & T- Cell Responses exist as prime reasons of AITD. ‘Cytokine interferon-gamma’ also show dynamic part in origin of HD disease. Radionuclide scan, physical inspection, fine needle aspiration, lymphocytic infiltrate, TPO, and TG detection (by RIA) are significant diagnosis parameters for ‘AITD’. Levothyroxin treatment intended for HT and antithyroid drugs are meant for GD. Observing of regular dosing is precarious for both therapies. The side effects of hormonal therapy could be avoided by using the herbal approach (Bacopa monnieri, Melissa officinalis, Withania...
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Posted by admin on Apr 30, 2023 in |
In recent days, the increasing number of microbes and their increasing resistance power against conventional drugs have led to enormous worldwide mortalities, hence they pose a great threat to human health. The modern era is already going through the threat of COVID-19, also caused by one of those microbes called the virus. In order to get a clear understanding, all the microbes have been classified in certain types. Nowadays, to develop new alternative antimicrobial medicines, scientists must acquire clarity about the responsible functional groups of different conventional drugs with proper mechanistic elucidation on different types of microbes. This information not only clarifies the functionalities and properties responsible for exhibiting antimicrobial effects, but also facilitates the idea of new drug development through proper functional group incorporation or modification. These modifications increase the efficacy of antimicrobial drugs as well as their activity and water solubility. In this review, my focus will majorly be on the four main types of microbes and their possible mechanistic elucidation of commonly used antibiotics and alternative...
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Posted by admin on Apr 30, 2023 in |
Oral controlled release and site-specific drug delivery systems have gained interest in the pharmaceutical industry to improve the treatment of certain critical medications. To overcome physiological barriers, such as short stomach resident lengths and variable gastric emptying periods, the idea of a novel drug delivery mechanism evolved. To improve the bioavailability of drugs with narrow therapeutic windows, delay the onset of drug elimination from the body, and increase patient compliance, one of these novel approaches is the gastroretentive drug delivery system (GRDDS), which is implanted in the upper part of the gastrointestinal tract. This investigation discusses the GRDDS, factors associated with the GRDDS, the advantages and disadvantages of the GRDDS, alternative approaches to the GRDDS, and different polymers used for gastroprotection. A great deal of work is being put into developing several GRDDS types at the moment. Because of this, pharmacotherapies of all types stand to benefit from their growing prominence...
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Posted by admin on Apr 30, 2023 in |
Plants are essential to the survival of every species on Earth. Animal and plant life have a history of mutual consumption since antiquity. Earth’s sole producers are plant is a fact. As researchers learn more about plants, this assumption is being challenged. The Rutaceae family’s citrus species Aegle marmelos (Bael), a well-known medicinal herb, has a lengthy study history. In addition to its useful nutrients, A. marmelos produces a wide range of secondary metabolites, or phytochemicals, during its whole life cycle. Roots, bark, stems, leaves, fruit, and flowers are all used by humans in some way or another obtained from the A. marmelos plant. Various phytochemical substances include various alkaloids, flavonoids, phenols, tannins, coumarins, saponins, carbohydrates, carotenoids, terpenoids, vitamins, and tannins generated by A. marmelos plants. The main phytochemical compounds isolated from A. marmelos plant are aegelenine, fragrine, halfordinol, marmelide, marmelosin, marmesin, marmin, psoralen, umbelliferone, limonene, rutin, skimmianine, lupeol, quercetin, esculetin, scopoletin, auraptene, seselin, etc. These phytochemical compounds obtained from the A. marmelos plant parts are being used since...
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