Posted by admin on Apr 30, 2023 in |
Most pharmaceutical drugs create problems during formulation as they are insoluble or poorly soluble in aqueous and non-aqueous mediums. It was proved that reducing the drug particle size increases the drug’s Solubility, Dissolution and Bioavailability. Many conventional techniques may be used, but the desired amount of particle size may not be achieved, and Solubility, Dissolution and Bioavailability still be a problem. Nanotechnology is a promising technique for formulating poorly soluble drugs. Nanotechnology helps us to reduce the drug particle size to submicron level and due to this, drug particle surface area increases which lead to solubilization of the drug. An increase in solubility leads to increased dissolution and Bioavailability of drug which leads to an increase in the drug’s effectiveness. Also, Nanotechnology has many advantages over conventional techniques. One of the most important advantages of Nanotechnology is that particle size can be reduced from 300 nm to 10µ. Nanotechnology helps us formulate insoluble drugs in aqueous and non-aqueous mediums into different dosage forms without using harsh organic solvents for...
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Posted by admin on Apr 30, 2023 in |
The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt of applicable keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty shops were named grounded on defined selection criteria for their potent anticancer composites. The detailed analysis of the exploration studies revealed that plants play a necessary part in fighting different cancers similar as bone, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in-vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis- converting enzymes by the secondary metabolites in the plant excerpts. Studies that reported in-vivo conditioning of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring further plants,...
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Posted by admin on Apr 30, 2023 in |
COVID-19, caused by Severe Acute Respiratory Syndrome CoV-2 (SARS CoV-2), has become a global burden. The naïve era of infection prompted early dependence on case reports of insufficient data and conceptual elucidation to explain and anticipate the effect on cardiovascular diseases. Many COVID-19-infected and vaccinated individuals have reported an increased incidence of cardiovascular disorders, leading to higher morbidity and mortality rates. Sometimes COVID can also manifest as a severe coronary artery disease or myocarditis in those with no background in cardiovascular diseases or those with cardiovascular risk factors, which are often misunderstood as a primary cardiovascular disorder. COVID-induced cardiovascular complications like DVT, VTE, MI, and long COVID have been the crux of the matter. To combat the SARS-CoV-2 disease, several countries took the lead in developing COVID-19 vaccines, but only a few were effective against coronavirus, which created a ray of hope in curbing COVID-19 disease. As the thumb rule says, any substance that is foreign to the body, including vaccines, has flaws seen in the forms of adverse...
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Posted by admin on Apr 30, 2023 in |
Plant or crude oriented herbs formulated products when they were application for their aromatic property in cosmetic formulation which known as or termed as herbal cosmetics. Now days it increasing demand for the herbal product has created new avenues in the cosmeceuticals market. Before some era, all cosmetics items were formulated in the house. Natural or herbs materials like aromatic materials, spices, herbs, resins, dyes, fats, oils, and the natives of different countries used perfumes. Natural product or Herbal Cosmetics, here in after referred to as Products, are formulated, using different valuable cosmetic components to formulate the base in that one or more natural or herbal components are using to provide defined cosmetic advantageous only, shall be called or that known as “Herbal Cosmetics or natural cosmetics”. Different types herbal components/additives is using in natural formulations contain bleaching agents, fixed oils, perfuming agents, waxes, antioxidants, protective agents, herbal colorants, critical oils, and plant fabrics that include leaves, gums, mucilage, etc. Herbal preparation is preparing herbal substances which are side-lining...
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Posted by admin on Apr 30, 2023 in |
Anti-diabetic medications, like insulin and glucagon-like peptide1(GLP-1) and its analogues are critical for diabetics to maintain blood glucose control. The difficulty of current insulin-based therapies for Type I & II diabetes mellitus, as well as the risks connected with fluctuations in blood glucose levels (hyperglycemia and hypoglycemia), served as the impetus for the establishment of “smart insulin” technology (glucose-responsive insulin; GRI). Insulin-dependent diabetes can be treated with glucose-responsive nanoparticles, a promising technology. The creation of nanoparticles of diverse sizes, features, and compositions allows for a variety of drug-delivery activities. When combined with a glucose measuring unit, this technology can give exogenous insulin more dependably and painlessly than conventional treatment. Nanoparticles made of polymers that are biocompatible and degradable have been created. These nanoparticles shield insulin from oxidation and make it easier for insulin to enter cells via a paracellular or transcellular pathway, whether or not they are linked to the nanoparticles. These techniques can potentially dramatically increase drug administration under controlled conditions, bioavailability, prolonged half-life, and clinical efficacy. The use...
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