Posted by admin on Jun 30, 2023 in |
Rheumatoid Arthritis (RA) is an autoimmune inflammatory illness characterized by persistent synovial inflammation. It’s the most common form of arthritis that causes inflammatory changes in the tissue of joints, destroys cartilage and bones, and affects the quality of life. This diverse disease has a wide range of disease progression and treatment responses. Because the precise origin of rheumatoid arthritis is still unknown, no medicine can ensure a full recovery. Biomarkers guide the clinical and pharmacological management of rheumatoid arthritis at all phases. This is because they can help in the monitoring of disease activity and progression, the prediction of illness beginning in at-risk patients, and the provision of predictive data. American College of Rheumatology (ACR) emphasized on initial investigation of clinical findings based on the physical data for the diagnosis of RA. Although Rheumatoid factor and anti-citrullinated protein antibodies are the two biomarkers that can be used to determine who is at risk for the condition and who has pre-clinical rheumatoid arthritis before symptoms develop, there are involvements of...
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Posted by admin on Jun 30, 2023 in |
The development of mucoadhesive buccal formulations has recently gained a great deal of attention. Despite several proposed solutions, drug permeability and regulated drug release via this mode of delivery remain concerns for successful therapy. Clinical uses for recent advances in nanotechnology have been examined. In addition to ensuring effective distribution, the use of nanoparticles in dosage forms for buccal administration also helps to minimize any negative effects on biological systems. To load and distribute drug-containing nanoparticles to the buccal mucosa for topical and systemic applications, several strategies have been proposed. In order to improve medication delivery or targeting, this study outlines contemporary cutting-edge approaches for using nanoparticles in dosage forms. Of give a general overview of current approaches to implementing controlled drug delivery, these technologies are categorized and discussed. All of these noteworthy results will promote novel nanoparticle-delivered dose formulations for buccal distribution in clinical settings. Overall, the buccal mucosa provides a lot of advantages for controlled pharmaceutical delivery over an extended period of...
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Posted by admin on Jun 30, 2023 in |
The genus Ailanthus, which includes both evergreen and deciduous species, is native to both Asia and northern Australia. Traditional medicine relies heavily on this plant, and various components of the plant are utilized to treat a wide range of illnesses. Herbal and ayurvedic drugs have gained worldwide attention over the past decade for their potential health and financial benefits. There are now major worries about the quality, safety, and efficacy of herbs due to their regular and extensive use around the world. As a result, credible scientific data or evaluation is required before health claims made about herbs may be considered valid. The foundation for this tree’s status as a plant of heaven includes the traditional assertions, phytochemical studies, pharmacological examination and some ayurvedic formulations. Therapeutic effects are found throughout the plant. The bark is employed in treating dysentery, earaches, skin diseases, rectum problems, fever related to tridosha and alleviating thirst. Furthermore, it is prescribed for patients suffering from bronchitis, asthma, bronchitis, dyspepsia, gout and rheumatism. In Ayurveda, it...
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Posted by admin on Jun 30, 2023 in |
Carbon dots are small nanoparticles having a size of less than 10nm. They have distinctive properties such as chemical stability, water solubility, fluorescence emission, easy synthesis, and low toxicity. Because of their special properties, they have been applied in various scientific disciplines. The fluorescence property of Carbon dots enables them for various biomedical applications such as bioimaging, drug delivery, gene delivery, and cancer therapy. Green synthesized fluorescent carbon dots have biomedical applications, especially for imaging and treatment of in-vitro cancer cells. Carbon dots have visible/natural light-activated antibacterial activities. This review discusses the recent advances of carbon dots in the medical field and their...
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Posted by admin on Jun 30, 2023 in |
An inflammatory disorder with an uncertain cause, rheumatoid arthritis (RA), is primarily distinguished by progressive cartilage loss resulting in persistent polyarthritis and joint deformity. Studies indicate that pannus development, which harms the cartilage and the bone, is caused by synoviocyte cellular growth, albeit the exact pathophysiology of the condition has not yet been determined. Recent research further supports free radicals’ significance in the disease’s etiology. In addition to the traditional therapy approaches, including glucocorticoids, disease-modifying antirheumatic medicines, and non-steroidal anti-inflammatory drugs, newer and safer drugs are constantly being sought after because prolonged use of these medications has led to adverse side effects. Through this review, we all have tried to explore different ancient Indian ancient Ayurvedic, Unani and Tibbi, as also some Oriental and Korean herbals for their very own potential for the treatment of...
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