Posted by admin on Nov 30, 2025 in |
Dementia is a collection of symptoms, including memory loss and cognitive impairment, that cause neuronal disruption and lead to certain mental illnesses. The most common cause of dementia is Alzheimer’s disease (AD). Potential causes of illness extension include tau aggregation, amyloid beta build-up outside of neurons, and the formation of neurofibrillary tangles (NFTs) inside neurons. At one point in time, Alzheimer’s disease was the most common illness worldwide. The majority of research indicates that ROS (Reactive Oxygen Species) play a significant role in neurodegeneration and, eventually, Alzheimer’s disease. Amyloid-peptide increases in Alzheimer’s disease led to an increase in ROS production, which kills neurons. A transcription factor called Farnesoid X Receptor (FXR) regulates inflammation, oxidative stress (OS), and the brain’s metabolism of fats and carbohydrates. Nuclear erythroid 2 related factor 2 (Nrf2) is a transcription factor that regulates the production of many antioxidant genes and is an essential regulator of neural defence against OS. According to certain studies, Nrf2 activation can regulate the expression and activity of FXR in the...
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Posted by admin on Nov 30, 2025 in |
Medicinal plants have long played a central role in traditional medicine systems for treating dermatological and metabolic disorders, including acne vulgaris, obesity, and hair fall. In this review, 70 peer-reviewed studies published between 2014 and 2025 sourced from PubMed, Scopus, Web of Science, and Google Scholar were systematically evaluated to explore the phytochemical profiles, pharmacological mechanisms, and therapeutic relevance of plant-based interventions for these conditions. This work examines the multifaceted actions of medicinal plants, focusing on antibacterial, anti-inflammatory, antioxidant, hormonal, and metabolic pathways. The review identifies key bioactive compounds such as curcumin, epigallocatechin gallate (EGCG), ginsenosides, thymoquinone, and Rosmarinic acid, which contribute to sebum regulation, adipocyte modulation, follicular stimulation, and immune response control. Notably, Azadirachta indica, Camellia sinensis, Garcinia cambogia, Panax ginseng, and Rosmarinus officinalis emerged as the most frequently studied and therapeutically promising plants. The proposed model highlights the role of phytomedicine in addressing the pathophysiology of these lifestyle-related conditions, aligning traditional knowledge with modern evidence. However, discrepancies in dosage, formulation, and extract standardization, along with a paucity...
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Posted by admin on Nov 30, 2025 in |
Locusts are well-known for their exceptional sense of smell, are emerging as potential bio-hybrid sensors that could be used in cancer detection. This review analyses the possible ways to develop their sensitive olfactory systems to detect volatile organic compounds (VOCs) released by cancer cells. Around 50,000 receptors remain present on the antennae of locusts, are capable to specify cancerous samples from non-cancerous matters. Recent review discussed about the possibility of coupling locust olfactory with bioelectronic devices or biosensingrobotic systems for cancer diagnosis. Locust olfactory receptor neurons (ORNs) are capable to detect fumes of VOCs and send signals through antennal lobes to projection neurons (PNs) where the signals are transformed to identifiable neural patterns. Again olfactory lobes are easy to modify by tissue culture. While the biohybrid concept is still incomplete and faced with issues of scalability and specificity, it has the potential to detect early-stage...
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Posted by admin on Nov 30, 2025 in |
Canine distemper is a highly contagious and often fatal disease affecting domestic dogs and a wide range of wild carnivores. Caused by the canine distemper virus (CDV), a morbillivirus, it presents with diverse clinical signs that can complicate timely diagnosis and treatment. Over the past decades, significant progress has been made in understanding the pathogenesis, improving diagnostic techniques, and developing supportive care strategies. This review provides a comprehensive overview of current advancements in the management of canine distemper, including innovations in antiviral therapies, immunomodulatory treatments, and supportive interventions. Additionally, it highlights recent developments in vaccination protocols and the role of molecular diagnostics in early detection and prognosis. Emphasis is placed on a multidisciplinary approach to treatment and prevention, aiming to improve survival rates and reduce the global burden of the disease. The review also identifies emerging research areas that could shape future management strategies for canine...
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Posted by admin on Nov 30, 2025 in |
Artificial Intelligence (AI) is rapidly transforming the pharmaceutical industry by enhancing every stage of drug development, from discovery to manufacturing and post-market surveillance. This article explores the diverse applications of AI, including machine learning, deep learning, and natural language processing, to accelerate the identification of drug targets, predict drug efficacy and safety, and optimize manufacturing processes. AI-driven technologies such as Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs) are being employed to analyze medical data, design new drug compounds, and improve clinical trials, reducing costs and timeframes. Additionally, AI is helping improve regulatory submissions and post-approval surveillance, ensuring better safety monitoring and real time decision making. Despite challenges such as data standardization and regulatory hurdles, the growing impact of AI in drug development is clear. AI promises to revolutionize the pharmaceutical industry, making drug discovery more efficient, cost-effective, and personalized, ultimately leading to faster delivery of safer treatments to patients. The continued advancement and implementation of AI technologies are poised to reshape pharmaceutical research and healthcare delivery on...
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