Posted by admin on Mar 31, 2023 in |
Omega-3 fatty acids are essential fatty acids present in regular animal and plant food diets. They play a key role in different body functions. Omega-3 fatty acids help to prevent central nervous system diseases. In this paper, we have shown the molecular basis of this effect. There isa number of studies showing the role of omega-3 fatty acids in the prevention of different central nervous system disorders. Omega-3 fatty acid plays a key role in brain development even during embryogenesis. It mainly shows a preventive effect against CNS disorders due to its anti-inflammatory action. Parkinson’s disease, migraine, schizophrenia, dementia and psychosis are some of the most abundant CNS disorders which are difficult to cure completely, especially in advanced stages. Omega-3 fatty acids, which can be obtained from a regular diet plan, have the potential to prevent and sometimes cure these disorders. Although in some cases the appropriate database is not available, all in all, it can be said that omega-3 fatty is plays a preventive role in most CNS...
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Posted by admin on Mar 31, 2023 in |
Advancements in X-ray crystallography, Nuclear magnetic resonance (NMR) spectroscopy, and innovation projects like the human genome project left gigantic amounts of biological information accessible to the common public, academicians, and industries. Computer-Aided Drug Design (CADD), such as molecular docking, is an ideal method to exploit this biological information in rapid drug development and discovery. The basic principle of molecular docking is explained in the present review, with a brief introduction to bioinformatics and Mycobacterium tuberculosis. Methodology and types of molecular docking are also described along with various software and programs used viz. AutoDock, FRED, FlexX and GOLD. Further, two fundamental wings of molecular docking techniques i.e., searching algorithms and scoring functions, are briefed. Molecular docking tools are discussed as their applications in the anti-tuberculosis drug discovery process. Drug molecules targeting various cellular enzymes important for the viability of multi-drug resistant M. tuberculosis studied using in-silico docking methods are reviewed. In contrast to high-throughput screening, molecular docking methods speed up the drug discovery process. It has been concluded that molecular...
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Posted by admin on Mar 31, 2023 in |
Naringin is a flavonoid isolated from different citrus fruits like Grapefruit, Orange, Pomelo, Lemon, etc, which are commonly called local fruit. Naringin is found in the white spongy portion of citrus peel. Its content varies from 0.65 mg/gm in the mandarin peel to 14.40mg/gm in the grapefruit peel. Naringin is metabolized to the flavanone naringenin by the enzyme Naringinase present in the liver. It can be analyzed by using various analytical techniques such as HPLC, TLC, UV, HPTLC, mass spectroscopy, Liquid chromatography, chiral chromatography and LC/Mass spectroscopy. Naringin can act as an antioxidant and scavenge free radicals. Naringin mainly focuses on in-vitro and in-vivo animal studies showing its beneficial effects on cardioprotective, antioxidant, anti-inflammatory, antimicrobial, hypolipemiant, neurological, thermogenic, pulmonary disorders and antidiabetic. Naringin is also treated as a most promising treatment strategy against Covid-19 due to its antiviral and anti-inflammatory effects. Recently, Naringin has proven its activity in various molecular docking studies. Naringin keeps the body healthy against various illnesses and major lifestyle...
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Posted by admin on Mar 31, 2023 in |
Medicinal plants play a vital role in human health as these are nature’s gift to human beings to make disease-free, healthy lives. The various families such as Amaranthaceae, Cucurbitaceae, Euphorbaceae, Fabaceae, Malvaceae, Myrtaceae, Orchidaceae, Piperaceae, Solanaceae etc. comprises several medicinal properties distributed in the tropical and subtropical region of India. The medicinal usage of these families has been reported in the traditional systems of medicine. An exhaustive literature survey was performed on the medicinal plants of the district which revealed that 90 plants belong to different families is reported antiulcer property used by tribal region. Different parts of Fabiaceae family plant extract are widely used by tribal (Gond Madiya Jamat) of Gadchiroli to heal ulcer and relieve stomach pain without precipitating any side effects. The present review was conducted and focuses on the ethnomedical, phytochemical and antiulcer activity of different plant extracts of the Fabiaceae...
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Posted by admin on Mar 31, 2023 in |
Magnetic nanoparticles are hugely used in hyperthermia, targeted drug delivery processes, diagnosis, extraction, and cellular imaging of biological molecules, which can be widely used in cancer treatment. The focus of attention is on formation, features, types, made work, coating material, and therapeutic application of magnetic nanoparticles. It also pivots in safety and biocompatibility in magnetic nanoparticles (MNPs). Particles within the size range of nanoscale exhibit magnetic properties and are known as magnetic nanoparticles (MNPs). The major advantage of magnetic nanoparticles is the targeting at the specific site. Various polymerization and coating of metals can be done, such as applying chemotherapeutic drugs to correct inherited diseases. The various process of Magnetic Nanoparticles formation through diagrammatical picture is also discussed in this article. This review discusses the therapeutic application, preparation method, features of magnetic nanoparticles, types, made work, surface coating, biocompatibility, and...
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