Posted by admin on Dec 31, 2022 in |
Nanotechnology is predicted to change health care essentially. The word nano originates from the Greek word “dwarf”. The idea of nanotechnology was first explained in 1959 by Richard Feynman. Nanotechnology has applications in many fields, including Medicine, Diagnostics, Drug delivery, Tissue engineering, Pharmaceuticals, Cosmeceuticals, Nutraceuticals, Dental materials, the Food industry etc. Nanotechnology is a multidisciplinary science that aims to design structures on a nanometric scale. Nanotechnology in drug delivery has appeared in nanoformulations with unique properties both in vivo and in vitro, particularly in targeted delivery. Nanotechnology has the potential to transform every aspect related to the food industry, food packaging, food storage, processing, pesticide, and food sensors which are some of the aspects of the food industry where prominent research is in progress utilizing the unique physicochemical properties of nanomaterials. Using these nanoparticles in the dietary supplement industry may improve supplement absorption and the bioavailability of drugs, nutraceuticals, and...
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Posted by admin on Dec 31, 2022 in |
Background: Solvents are major part in chemical industry. Solvents have major impact on cost as well as safety and health issues. Many more organic solvents are considered toxic. Thus the concept of green chemistry is introduced which eliminate or reduce the use of hazardous solvents/chemicals from analytical process for the eco-friendly environment and health without any compromise in Analytical performance. Aim: Thus, the green chemistry goals to eliminate the use of hazardous chemicals and to search the non-hazardous solvents. Some of the methods are identified that are eco-friendly which replace the use of harmful organic solvents by use of alternatives such as The EHS method, bio-solvents, solvent less preparation techniques, RP-HPLC and UP-HPLC, Micellar liquid chromatography, Eco-friendly and economic analytical methods using hydrotropic solubilization. Result and Discussion: From the results it is identified that Contamination prevention, whether through green chemistry or other means, will be challenging for the environmental...
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Posted by admin on Dec 31, 2022 in |
Liposomes are considered to be safe for usage; they have been used hugely in cosmetics. Biologically obtained compounds of phospholipids have a high affinity to the skin’s surface. Liposomes are highly permeable and have more storage capacity on the stratum corneum and also it is considered a chemically active agent to the skin. Most future studies on liposomes involve drug delivery in cosmetics. Liposome formulations are prepared from phospholipids of variant sources like egg and soya; they were differentiated in terms of their result on the skin like water content, Elasticity, Barrier function. Liposome has a variety of phospholipids giving a variety of effects on the skin humanity. Antioxidant and anti-inflammatory activity is a category poses by the plant of phenolic compound metabolite. The ideal property of the compounds are stable and also act as a bioactive ingredient in plants, but it will give the property after the process of extraction; they are considered to be very sensitive to light and heat sources; they have the property like speed...
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Posted by admin on Dec 31, 2022 in |
The most commonly used analytical method in drug research is reversed-phase high-performance liquid chromatography (RP-HPLC). RP-HPLC methods also use huge quantities of solvents and generate by-products that must be disposed of, posing environmental and operator health worries. Micellar Liquid Chromatography (MLC) is a green chromatographic process for pharmaceutical analysis in which surfactants are applied above the Critical Micellar Concentration in the mobile phase (CMC). The ability of micelles to solubilize compounds that are not soluble or sparingly soluble in water is one of their properties; this property is critical for advancing analytical methods. MLC is also compliant with current RP-HPLC systems. As a result, no changes to the current RP-HPLC instrument are needed. MLC (micellar liquid chromatography) is a green and long-term method for analyzing medication compositions. MLC is not only the more environmentally friendly option, but it is also the more cost-effective. It is believed to have a mobile phase of 90% or more water (v/v), which can be recycled if injection volumes are small and far apart....
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Posted by admin on Dec 31, 2022 in |
Metformin (MET) is a biguanide class of oral hypo-glycaemic agent which is used in the treatment of diabetes mellitus type II. Currently, MET is the first drug of choice and is primarily prescribed by medical practitioners to at least 120 million people worldwide. The quality-oriented routine analysis of various commercially available products of MET is a major challenge. Several methods have been reported in an industrial scale for thorough quantitative analysis. This review article comprehensively examines the published sophisticated instruments-based nearly 50 analytical methods in various pharmaceutical databases like Google Scholar, PubMed, etc. of diverse area of High-Performance Liquid Chromatography (HPLC). The determination of MET in plasma, serum, and urine, extensively requires the HPLC method. For the determination of MET in biological samples, we recommend the LC-MS/MS method since this method combines the HPLC separation ability with MS sensitivity and selectivity, allowing the identification of MET and its metabolites. For pharmaceutical analysis, HPLC with UV detection method is applicable because this method provides accurate results and low cost compared...
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