Posted by admin on Mar 31, 2023 in |
Background: Warfarin is an anticoagulant widely used to prevent thromboembolic events (TEs) in patients with various cardiovascular (CV) diseases. Pharmacogenomics (PGx)-guided testing is a growing method suggested to help predict warfarin dosing. A systematic review was performed to compare the incidence of thromboembolic events (TEs), bleeding events (BEs), time in therapeutic range (TTR), the proportion of time to therapeutic range (PTTR) and warfarin dose adjustments between PGx-guided warfarin therapy and standard of care (SOC) in patients with non-valvular atrial fibrillation (Afib), pulmonary embolism (PE), and deep vein thrombosis (DVT). Methods: Two reviewers independently searched MEDLINE, CINAHL, Web of Science, Embase, Cochrane Library and clinicaltrials.gov databases from October 2019-August2022 to identify studies. Abstracts were reviewed for outcomes of interest and patient demographics to identify patients present with International Normalized Ratio (INR) readings, TTR, PTTR, BEs and TEs. Results: From the database search, 28 articles were retrieved based on abstract screening. A total of 6 articles were ultimately selected for the systematic review. All articles found favor in the PGx-guided group...
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Posted by admin on Mar 31, 2023 in |
Depression is accepted as a condition of misery and is treated as a disorder that includes mental and emotional disorders. Depression is a deadly disease that affects about 5% of the general population. In addition, depression is a heavy burden on patients and families. Furthermore, many epidemiological studies have shown that the occurrence of depressive disorders in the general population is increasing at an alarming rate. Depression is the most common form of emotional disorder, from a very mild condition to severe depression associated with hallucinations and delusions. In addition, altered levels of serotonin and other biogenic amines have also been shown to contribute to neuromodulatory disturbance in the etiology of depression. According to monoamine theory in depressive disorder, patients with major depression have shown biochemical symptoms which may change monoamine neurotransmitters, specifically nor-epinephrine and serotonin. Clinical data suggested that dopamine is also involved in the pathophysiology and treatment of...
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Posted by admin on Mar 31, 2023 in |
Cosmetic products are produced by the most inventive and technically driven methods to reach more consumers in the developing world. Cosmetic products are also regulated, similar to pharmaceutical products. BRICS countries are emerging markets with a partial regulatory system similar to well-regulated countries. BRICS countries have a registration or notification process for cosmetics based on their classification. A systematic review was carried out. We searched the databases and reviewed assessment agency websites, among other sources. Qualitative studies, official regulations, and systematic reviews aimed to identify a general framework of regulatory activity in BRICS were included. A critical analysis is made of all the aspects that may be useful for any public body that intends to register cosmetics in any of the BRICS countries. BRICS nations are organized to promote, stabilize and consistently regulate cosmetic products among them. The cosmetic regulatory system, registration process, and procedures of South Africa are at their last position, as Russia precedes South Africa. Cosmetic products are very well regulated and the registration process is...
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Posted by admin on Mar 31, 2023 in |
Omega-3 fatty acids are essential fatty acids present in regular animal and plant food diets. They play a key role in different body functions. Omega-3 fatty acids help to prevent central nervous system diseases. In this paper, we have shown the molecular basis of this effect. There isa number of studies showing the role of omega-3 fatty acids in the prevention of different central nervous system disorders. Omega-3 fatty acid plays a key role in brain development even during embryogenesis. It mainly shows a preventive effect against CNS disorders due to its anti-inflammatory action. Parkinson’s disease, migraine, schizophrenia, dementia and psychosis are some of the most abundant CNS disorders which are difficult to cure completely, especially in advanced stages. Omega-3 fatty acids, which can be obtained from a regular diet plan, have the potential to prevent and sometimes cure these disorders. Although in some cases the appropriate database is not available, all in all, it can be said that omega-3 fatty is plays a preventive role in most CNS...
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Posted by admin on Mar 31, 2023 in |
Advancements in X-ray crystallography, Nuclear magnetic resonance (NMR) spectroscopy, and innovation projects like the human genome project left gigantic amounts of biological information accessible to the common public, academicians, and industries. Computer-Aided Drug Design (CADD), such as molecular docking, is an ideal method to exploit this biological information in rapid drug development and discovery. The basic principle of molecular docking is explained in the present review, with a brief introduction to bioinformatics and Mycobacterium tuberculosis. Methodology and types of molecular docking are also described along with various software and programs used viz. AutoDock, FRED, FlexX and GOLD. Further, two fundamental wings of molecular docking techniques i.e., searching algorithms and scoring functions, are briefed. Molecular docking tools are discussed as their applications in the anti-tuberculosis drug discovery process. Drug molecules targeting various cellular enzymes important for the viability of multi-drug resistant M. tuberculosis studied using in-silico docking methods are reviewed. In contrast to high-throughput screening, molecular docking methods speed up the drug discovery process. It has been concluded that molecular...
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