Posted by admin on Jun 30, 2025 in |
The central nervous system disorders represent a worldwide public health problem. Neurodegeneration is associated with many transitions in brain including synaptic disorder and neuro cognition decline. It is shielded by a barrier which controls the entry of compounds into the brain known as blood brain barrier (BBB), thereby regulating brain homeostasis. In achieving a therapeutic amount of drug to the proper site of action in the body and then maintaining the desired amount of drug concentration for a sufficient time interval to be clinically effective for treatment. Particularly, neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are becoming further established in the elderly inhabitants of the society. These ailments usually encompass advanced degeneration & neuronal loss, rendering these disorders spread and difficult to treat. There are various types of pharmaceutical approaches to treat neurological disorders. The drug loaded nanocarriers are one of them. In this review, we will address the different applications of drug loaded nanocarriers in the treatment of various neurological disorders. Moreover, integration of...
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Posted by admin on Jun 30, 2025 in |
Acne vulgaris is a multifactorial skin disorder of pilosebaceous unit which majorly affects teenagers, but it can continue into adulthood and cause aesthetical as well as psychological problems. This review article enlightens the knowledge related to cause and treatment of acne vulgaris. Several factors which are involved in the development of acne vulgaris are hormonal activity, sebum production, follicular epidermal hyperproliferation, colonization with Propioni-bacterium acnes (P. acnes) and inflammation. There are several treatment methods available for acne, although some new therapeutic agents have been introduced during the last few years; synthetic drugs still remain the best option in the treatment of acne. However, rapid appearance of antibiotic resistance and high re ocurrence rates have led to a search for alternatives in nature. The use of herbal drugs in prevention and treatment of acne vulgaris nowadays increased because of their efficiency, availability and lesser side effects than synthetic drugs. Some common used topical herbal remedies with significant anti-inflammatory activities antimicrobial activities have mentioned in this review article include tea tree...
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Posted by admin on Jun 30, 2025 in |
Diabetes is a multifaceted metabolic disorder that impacts individuals worldwide, and delayed wound recovery is a prevalent symptom of diabetes. There is a plethora of methods available now to heal these wounds. Since, chronic inflammation and untreated stages may lead to amputation and death. So, their consequences may cause a patient’s financial strain. However, this review focuses on the most recent formulation, such as miRNA, biomarkers, exosomes, leucine-rich glycoprotein, neutrophils, pro-inflammatory (M1) macrophages, pro-remodeling (M2) macrophages, sustained activation of neutrophils, endothelial progenitor cells, Scaffold, biofilms, carriers, fibers, mats, and antibiotic management for diabetic wound treatment. We discussed their roles as well as therapy plans for managing diabetic wounds with the latest...
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Posted by admin on Jun 30, 2025 in |
Background: Intravascular lithotripsy (IVL) is an innovative method for treating heavily calcified coronary and peripheral lesions. It employs acoustic shock waves to create microfractures in calcified plaques, facilitating stent placement and improving vessel compliance. Objective: To assess the efficacy, safety, and potential applications of IVL in hypertensive patients with calcified coronary lesions, while exploring its diagnostic and therapeutic capabilities. Methods: A thorough review of the latest advancements and studies on IVL, with a focus on its use in hypertensive patients. Key studies, including the Disrupt CAD series, were analyzed for procedural success, safety, and clinical outcomes. The integration of IVL with imaging techniques such as intravascular ultrasound (IVUS) was also investigated. Results: IVL has shown high procedural success rates and minimal complications in treating calcified coronary and peripheral lesions. Studies have reported significant luminal gain post-IVL, with minimal residual stenosis. The Disrupt CAD studies confirmed the safety and efficacy of IVL, with minimal adverse events and substantial calcium fracture in treated lesions. IVL’s effectiveness in managing specific clinically significant...
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Posted by admin on Jun 30, 2025 in |
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age. It is characterized by symptoms such as elevated androgen levels, the presence of multiple cysts on the ovaries, irregular or absent ovulation and various metabolic disturbances. Women with PCOS commonly experience metabolic dysfunction, obesity and infertility. They also face a higher risk of pregnancy complications and long-term cardiovascular disease. About 75% of individuals with PCOS have Insulin Resistance (IR). IR can trigger symptoms of PCOS, but hyperandrogenemia related to PCOS can also worsen IR. This review aims to summarize the current treatment options for managing IR in PCOS and to prevent the long-term complications associated with it. Current treatment strategies include lifestyle modifications, which remain foundational for improving metabolic health, alongside pharmacological interventions such as Metformin, Thiazolidinediones, GLP-1 Receptor Agonists (GLP-1 RA) and SGLT-2 (Sodium Glucose Co-transport) inhibitors. These established therapies offer significant benefits in managing IR and associated symptoms. Additionally, Inositol has gained recognition for its role in supporting metabolic and reproductive outcomes. Emerging...
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