Posted by admin on Mar 31, 2023 in |
Naringin is a flavonoid isolated from different citrus fruits like Grapefruit, Orange, Pomelo, Lemon, etc, which are commonly called local fruit. Naringin is found in the white spongy portion of citrus peel. Its content varies from 0.65 mg/gm in the mandarin peel to 14.40mg/gm in the grapefruit peel. Naringin is metabolized to the flavanone naringenin by the enzyme Naringinase present in the liver. It can be analyzed by using various analytical techniques such as HPLC, TLC, UV, HPTLC, mass spectroscopy, Liquid chromatography, chiral chromatography and LC/Mass spectroscopy. Naringin can act as an antioxidant and scavenge free radicals. Naringin mainly focuses on in-vitro and in-vivo animal studies showing its beneficial effects on cardioprotective, antioxidant, anti-inflammatory, antimicrobial, hypolipemiant, neurological, thermogenic, pulmonary disorders and antidiabetic. Naringin is also treated as a most promising treatment strategy against Covid-19 due to its antiviral and anti-inflammatory effects. Recently, Naringin has proven its activity in various molecular docking studies. Naringin keeps the body healthy against various illnesses and major lifestyle...
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Posted by admin on Mar 31, 2023 in |
Medicinal plants play a vital role in human health as these are nature’s gift to human beings to make disease-free, healthy lives. The various families such as Amaranthaceae, Cucurbitaceae, Euphorbaceae, Fabaceae, Malvaceae, Myrtaceae, Orchidaceae, Piperaceae, Solanaceae etc. comprises several medicinal properties distributed in the tropical and subtropical region of India. The medicinal usage of these families has been reported in the traditional systems of medicine. An exhaustive literature survey was performed on the medicinal plants of the district which revealed that 90 plants belong to different families is reported antiulcer property used by tribal region. Different parts of Fabiaceae family plant extract are widely used by tribal (Gond Madiya Jamat) of Gadchiroli to heal ulcer and relieve stomach pain without precipitating any side effects. The present review was conducted and focuses on the ethnomedical, phytochemical and antiulcer activity of different plant extracts of the Fabiaceae...
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Posted by admin on Mar 31, 2023 in |
Magnetic nanoparticles are hugely used in hyperthermia, targeted drug delivery processes, diagnosis, extraction, and cellular imaging of biological molecules, which can be widely used in cancer treatment. The focus of attention is on formation, features, types, made work, coating material, and therapeutic application of magnetic nanoparticles. It also pivots in safety and biocompatibility in magnetic nanoparticles (MNPs). Particles within the size range of nanoscale exhibit magnetic properties and are known as magnetic nanoparticles (MNPs). The major advantage of magnetic nanoparticles is the targeting at the specific site. Various polymerization and coating of metals can be done, such as applying chemotherapeutic drugs to correct inherited diseases. The various process of Magnetic Nanoparticles formation through diagrammatical picture is also discussed in this article. This review discusses the therapeutic application, preparation method, features of magnetic nanoparticles, types, made work, surface coating, biocompatibility, and...
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Posted by admin on Mar 31, 2023 in |
Background: Oral disintegrating tablets are strong dosage forms comprising medications that disintegrate throughout the oral cavity in less than 1 minute. Quality by designis a modern approach to pharmaceutical quality. Pharmaceutical Quality Design and discusses the use of Quality Design to maintain the quality of Pharmaceuticals. Methods: The frequent screening design, such as 32 factorial design, Box-Behnken, placket-Burman, optimization designs, 23 factorial design, and Central composite designs, including analysis of variance, are used. Conclusion: Quality by Design can be used to develop and evaluate methodological methods. Critical analytical variables are defined in an approach that is consistent with the process improvement referred to in ICH Q8 and Q9. This latest quality-by-design mechanism would incentivize even greater regulatory stability in the future. Formulations of Oral disintegration tablets were optimized with the help of quality by design. In the present article, an effort was made to review different screening designs employed in optimization formulations of oral disintegrating...
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Posted by admin on Mar 31, 2023 in |
Nanotechnology is an interdisciplinary field of science that refers to the research and technology development at atomic, molecular, and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales that range from 1nm to 100 nm. During the past few decades, a surfeit of nanomaterials (NMs) and nanoparticles (NPs) has evolved and been evaluated for their potential to improve the clinical treatment and diagnosis of a patient as diagnostic and therapeutic agents. Real exposure has been generated around the probable effects of the NMs and NPs for novel therapeutic approaches against several diseases, including cancer, to cope with the threats of the malignant tumour. Few nanoparticles also exhibit strong antimicrobial activity against Gram-positive and Gram-negative bacteria and act as antibacterial agents for treating different bacterial infections. A wide variety of nanomaterials, both carbon nanomaterials (CNMs) such as graphene, fullerenes, carbon nanotubes, and metal nanoparticles (MNPs), including gold, silver, and zinc oxide with distinctive physicochemical properties, provides opportunities to be explored in the...
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