Posted by admin on Dec 31, 2022 in |
The eye is one of the most sensitive organs of human body and is continuously exposed to different environmental agents so it is very important to take care of eyes. Poor vision makes it harder to read, drive, and cook. Many eye problems and diseases can be treated if caught early. Ophthalmologists will examine eyes for signs of vision problems or eye diseases. It’s the best way to find out if glasses or contacts are needed in the early stages of a serious but treatable eye disease. Wearing protective eyewear when playing sports or doing activities around the home, smoking cessation, wearing UV radiation-blocking sunglasses, Cleaning hands and contact lenses properly to avoid the risk of infection, etc., are the steps to protect...
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Posted by admin on Dec 31, 2022 in |
Nanoparticles with lipids as a constituent are called “solid lipid nanoparticles” (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aids in the solubilization of lipophilic compounds. The evolution of multidrug resistance therapy against various chemotherapeutic agents, tissue toxicity, and a high prevalence of drug-resistant tumors are the most common impediments in the clinical management of cancer. For more than a decade, SLNs have been widely used as drug delivery systems in the treatment of various cancers due to their low toxicity, high drug bioavailability, and usefulness with hydrophilic and lipophilic drugs. In this review, we discussed the incorporation and controlled delivery of different cytotoxic anti-cancer drugs to target sites using SLNs to treat various...
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Posted by admin on Dec 31, 2022 in |
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine is known from time immemorial. Chronic and complicated diseases have been cured with plant-based products. Considering their importance in manufacturing new medicines, their efficacy and safety have become a major concern. This literature review reviews some investigated plants that have shown promising results in mitigating peptic ulcers at different doses. Preliminary phytochemical screening of these herbs has shown the presence of important secondary metabolites like flavonoids, alkaloids, terpenoids, tannins which are responsible for the anti-ulcer activity. Acute toxicity studies have proved the safety of the selected plant extracts. This article reviews the overall active constituents, anti-ulcer, gastro protective activity of some medicinal plants investigated between...
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Posted by admin on Dec 31, 2022 in |
Any bodily harm, such as damage to the skin’s epidermis and disruption of its normal architecture and function, is referred to as a wound. The significance of wound healing has been known since ancient times. Several attempts have been made to design innovative wound dressings composed of the finest materials for speedy and successful wound healing. Medicinal herbs greatly aid the wound healing process. Many researchers have concentrated in recent decades on creating innovative wound dressings that combine medicinal plant extracts or their purified active components, which might be utilized instead of standard wound dressings. Several researchers have looked at the mechanisms of action of different herbal medicines in the wound healing process. This work aims to emphasize and examine the mechanical viewpoint of wound healing mediated by natural compounds. Some herbal medications stimulate re-epithelialization, angiogenesis, granulation tissue development, and collagen fiber deposition by increasing the production of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF-α). Other wound dressings containing herbal medicines decrease the production of tumour...
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Posted by admin on Dec 31, 2022 in |
BioMarin Pharmaceutical is developing Vosoritide, a modified recombinant human C-type natriuretic peptide (CNP) analogue for the treatment of achondroplasia. A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3), a negative regulator of bone growth, causes achondroplasia. Vosoritide works to restore chondrogenesis by attaching to the natriuretic peptide receptor B (NPR-B), which inhibits the hyperactive FGFR3 gene’s downstream signalling pathways. In August 2021, the European Union approved Vosoritide for the treatment of achondroplasia in children under the age of two whose epiphyses are not closed; the diagnosis of achondroplasia should be validated by genetic testing. In the United States, the medication is also undergoing regulatory assessment for the treatment of achondroplasia and clinical trials. Several countries are in the process of developing. The milestones in the development of vosoritide that led to this first approval for achondroplasia in children under the age of two whose epiphyses are not closed are summarized in this article. Vosoritide is a medication that was designed to treat achondroplasia and has shown...
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