Posted by admin on Dec 31, 2022 in |
Recently, scientific investigations of medicinal plants using indigenous medical systems have attracted a lot of attention in international investigation. Nature has imparted our planet with an enormous wealth of medicinal plants known for bestowing and are highly esteemed worldwide as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Herbal drugs can be potential drugs to replace them. Every year, many plants from the traditional medicinal system may be screened for their potential analgesic activity. Still, only a few of them only included in the health care system after clinical research. So this is time to give more emphasis on research work based on natural sources, investigate the active phytochemical constituents, and use them on a specific...
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Posted by admin on Dec 31, 2022 in |
Drug addiction has become a worldwide problem and the leading cause of death. In recent years, India is seeing a rising trend in drug addiction. The most common drug use in India is alcohol, followed by cannabis and opiates. Drug use, whether licit or illicit, causes serious health problems in individuals. The national survey on drug use in India indicated that the prevalence of drug abuse among males in the general population is significant. Economic burdens disturbed family environments, violence, and psychological problems are other consequences of drug abuse in the family. Adolescent drug abuse is another major area of concern because more than half of the person’s with substance use disorder are introduced to drugs before the age of 15-year Drug treatment is intended to help addicted individuals stop compulsive drug seeking and use. Treatment can occur in a variety of settings, take many different forms, and last for different lengths of time. Because drug addiction is typically a chronic disorder characterized by occasional relapses, short-term, one-time treatment...
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Posted by admin on Dec 31, 2022 in |
A periodontal disease is a group of pathological diseases, i.e., a widespread infectious disease that mainly causes tooth loss in 15% of adults worldwide. For the treatment of these periodontal diseases, localization of the drug is necessary i.e.; the drug has to be delivered to the periodontal pocket, which is the main area for the development of bacteria. So, researchers have made many attempts to develop the treatment of periodontal disease, including drug delivery to the infection site and regeneration approaches; they really provide a useful experimental mode for evaluating therapies for future periodontal diseases. This review mainly focuses on the pathogenesis of periodontal diseases, the process of fabrication of nanofibers using electrospinning techniques, and mainly how these electrospun nanofibers are used in the treatment of periodontal diseases. And gives an overview of how antibiotics, antimicrobial agents, and nanocomposite electrospun nanofibers are used in the treatment of periodontal...
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Posted by admin on Dec 31, 2022 in |
Three-dimensional printing (3DP) is an imminent technology used to describe 3D products generated using a digital design platform manufactured layer by layer. This technology appears to be a transformative tool. It has just emerged as a key technological breakthrough, allowing the pharmaceutical sector to develop and generate new pharmaceutical items and equipment. It’s a brand-new way to personalize pharmaceutical formulation and design. Spiratam® (levetiracetam), the first commercial 3D tablet, was approved by the FDA in August 2015, sparking a rise in interest in employing this platform for pharmaceutical development. Following the FDA’s approval of the first 3D printed tablet, Spritam. The concept can benefit patients, pharmacists, and the pharmaceutical business by enabling the on-demand design and fabrication of flexible formulations with customized dosages, forms, sizes, drug release, and multi-drug combinations. This is a watershed moment in the history of 3D printing in pharmaceuticals, needing the involvement and assistance of healthcare professionals like pharmacists, doctors, nurses, and pharmacy technicians, among others, to enable wider use of the technology. This article...
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Posted by admin on Nov 30, 2022 in |
SMEDDS are formulated to improve the oral bioavailability of lipophilic drugs. It is an isotropic mixture of compounds like oil, surfactant, co-surfactant, and drug having the unique ability to form fine o/w micro-emulsion by agitation and diluted with GI fluid. Its liquid formulation technique enhanced the absorption and bioavailability of poorly water-soluble drugs but also had a few drawbacks like long time period stability issues and storage conditions. Some special techniques convert the liquid form into solid dosage form to overcome these problems. The present paper gives exhaustive information about formulation design by screening excipients. We study the selection and solubility of excipients, its preparation and characterization, and the mechanism by which bioavailability can be improved. This discussion is useful for a better understanding of SMEDDS for its recent advancements, marketed formulation, and patents on SMEDDS. The poorly water-soluble drugs having dissolution rate absorption limited can be effectively formulated in the form of SMEDDS causing a stable plasma profile. The plasma levels of the poorly aqueous soluble medicament show...
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