Posted by admin on Nov 30, 2022 in |
Severe viral infections like Covid-19 are emerging now a day and are the common causes of human illness and death. Presently, we have a limited availability of antiviral chemotherapeutic agents to prevent and treat these infections, so it is the need of an hour to develop potential antiviral drugs against various harmful and fatal viral infections. A large quantity of research has been performed on 1,2,3 triazole and their derivatives, which has proved the promising antiviral activity of this heterocyclic nucleus. Among nitrogen-containing heterocyclic compounds, 1, 2, 3-triazoles are privileged structure motifs and received great attention in academics and industry. Even though absent in nature, 1, 2, 3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. 1, 2, 3 triazole nucleus is one of the most important and well-known heterocycle which is a common and integral skeleton of a variety of medicinal compounds like antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antiobesity...
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Posted by admin on Nov 30, 2022 in |
Beginning from simple analytical methods to the recent development of advanced hyphenated techniques stages, various analytical methods have been designed for the multicomponent analysis of drugs. Simultaneous estimation of drugs in the combined dosage form is vital in the pharmaceutical analysis since it is cost-effective and time-saving. Levocetirizine, the R-enantiomer of Cetirizine, is a peripheral H1-receptor antagonist used as a non-sedative antihistamine in treating chronic idiopathic urticaria, angioedema, and allergic rhinitis. Montelukast Sodium is selective cysteinyl leukotriene I receptor inhibitor that acts as an anti-asthmatic agent in the bronchial tubes and lungs. The combination of Levocetirizine with Montelukast Sodium in the pharmaceutical formulation is frequently used in the treatment of Allergic rhinitis as it has been shown to have additional benefits to the patients in reducing the symptoms efficiently. This review article has compared and addressed a variety of analytical methods applied for estimating Levocetirizine and Montelukast Sodium in the combined dosage form. The methods include UV Spectrophotometry methods, High-Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), and...
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Posted by admin on Nov 30, 2022 in |
Plants are the natural sources of a vast diversity of molecules, exploited for the benefit of human health. They are the factories synthesizing proteins, carbohydrates, secondary metabolites, and biopolymers. Further, converting these molecules into antioxidants, pharmaceuticals, food, and biofuels is a major industrial process. Plants are becoming significant sources for producing pharmaceutically essential proteins, metabolites, vaccines, industry-based drugs, and bioplastics and are explored for large-scale production. Plant molecular pharming will enable the production of the desired therapeutic proteins. Plant-based pharmaceutical products are advantageous as they are free of vectors and pathogens utilized to transfer genes. Biopharming offers augmented breeding conditions, high biomass productivity, and excellent yield at low cost, making the plants an attractive platform for pharmaceutical production. The ability of plants to produce pharmaceutical-related products and the methodology involved in the production were discussed in this article. Technologies implemented for increased productivity of molecular pharming were also discussed, along with biopharma products, applications and...
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Posted by admin on Nov 30, 2022 in |
Normally, there are two major sexual grievances in men; Erectile dysfunction or impotence and premature ejaculation. Premature ejaculation (PE) is a condition where the orgasm or the emission of semen occurs sooner during sexual intercourse. Erectile dysfunction (ED) is a sexual dysfunction mainly characterized by the inability to either develop an erection or maintain an erection of the penis during sexual intercourse. ED is found to be more prominent in elderly and mature men. As reported in the previously conducted studies, the health-related influences for ED include hypertension, dyslipidemia, diabetes, depression, and heart ailments. As the age increases, the prevalence also increases, especially the age group of 60 to 69 years showed the highest incidences of ED. The median age was of 65 years among all the participants reporting ED. With the increasing tendency in life expectancy in the western countries, and the high prevalence of health ailments like diabetes and various Cardiovascular disorders, the impact on lifestyle and eminence of life imposed by ED in men is likely...
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Posted by admin on Nov 30, 2022 in |
Even though viral hepatitis is a major public health concern around the world. It now has the attention and financial support of global health decision-makers. Every year, over 1.4 million individuals die due to viral hepatitis-related cirrhosis and liver cancer, with the majority of the population being unaware of their illness. This demographic has numerous challenges, including a profound ignorance, bias, inadequate access to health resources, and the implementation of innovative programs and policies. Even after implementing new strategies to manage the illness in recent years, the projected decline has not been evident. The study’s major goal is to show current global illness frequency levels and investigate precautionary measures. The study’s information and findings came from published scientific publications, online sources, and various search...
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