Posted by admin on Apr 30, 2020 in |
This research work presents the phytochemical and FTIR analysis, total phenolic, and flavonoid quantification, and evaluation of in-vitro antibacterial and antioxidant activity of ethanolic root extract of Millettia pinnata. Ethanolic root extract was subjected to the phytochemical and FTIR spectrum analysis. Total phenolic and flavonoid contents were quantitatively determined by Colorimeter. The antibacterial activity against Gram-positive, Gram-negative, and in-vitro antioxidant activity of ethanolic root extract of Millettia pinnata was determined by using agar well diffusion method and DPPH radical scavenging method. Phytochemical screening revealed carbohydrates, glycosides, alkaloids, steroid and triterpenoids, tannins, polyphenols, and phenolic compounds. FTIR spectrum of ethanolic root extract was obtained and confirmed the presence of functional groups. The intense bands indicate the presence of N-H2, O-H stretch, C-H stretch, C=O, C=C, C-H Benzene, C-O stretch, and C-Cl. The total phenolic and flavonoid contents of the ethanolic root extract were found to be 8.976 ± 0.0833 GAE mg/g and 4.9 ± 0.2516 RUE mg/g of dry extract. The extract showed bactericidal activity, zone of inhibition was determined...
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Posted by admin on Apr 30, 2020 in |
Tectona grandis is famous as a valuable timber hold an extensive range of applications around the sphere. In addition to its enormous uses in the timber industry, all the parts are cherishing with extensive use in traditional medicine and possess significant pharmacological properties. In search of drugs for diabetes, the methanolic seed extract which is prepared by the Soxhlet apparatus, was used for investing the bioactive compounds and anti-hyperglycemic potential in alloxan-induced diabetic rats. The results revealed that preliminary phytochemical analysis revealed the presence of distinct secondary metabolites like xanthones, glycosides, flavonoids, saponins, proteins, amino acids, and carbohydrates. The extract exhibited significant diminution in blood glucose levels in the given alloxan-induced diabetic rat model at 100 mg/kg and 200mg/kg dose using metformin as a reference...
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Posted by admin on Apr 30, 2020 in |
The quality of treatment and management of uncomplicated malaria depends on healthcare workers’ and patients’ characteristics, in addition to resource availability. This study assessed predictors of healthcare workers’ knowledge, attitudes, and practices (KAP) on uncomplicated malaria in primary healthcare (PHC) facilities in Plateau state, Nigeria. Secondary data of 289 healthcare workers involved in the management of the disease in PHC facilities of Plateau state were used for the study. Also, data on the availability of material resources for managing the disease in the PHC facilities were collected using a facility review form (FRF). Multinomial logistic regression analyses were performed to identify predictors of healthcare workers’ KAP on uncomplicated malaria. The findings revealed age (years old) (p = 0.032), occupation (p = 0.004), monthly salary (p = 0.021), availability of required drugs (p = 0.046), and practices (p = 0.001) as significant predictors of healthcare workers’ knowledge on uncomplicated malaria, with only monthly salary (p = 0.049) predicting their attitudes on the disease and its management. Their gender (p =...
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Posted by admin on Apr 30, 2020 in |
The present investigation deals with the development and evaluation of floating microballoons of furosemide to extend the gastric residence time (GRT) and prolong the drug release. In the present work, floating micro balloons of furosemide were formulated using eudragit RS 100, eudragit S 100, and HPMC K4M and ethylcellulose polymers by the solvent evaporation method. The prepared micro balloons were evaluated for their physicochemical properties, in-vitro drug release, and in-vitro buoyancy. The in-vitro release studies demonstrated that micro balloons of furosemide prepared using eudragit RS 100 along with eudragit S 100 in 1:1 ratio (FSDF10) shown the maximum amount of drug release; hence it is considered as the optimized formulation. The in-vitro release kinetics revealed that the optimized formulation releases the drug in zero-order manner based on the regression values of kinetic models. The optimized formulation was used for in-vivo evaluation. The in-vivo Radiographic study showed that the BaSo4 loaded optimized formulation remained buoyant up to 5.5 h in the stomach. The in-vivo pharmacokinetic study conducted in healthy albino...
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Posted by admin on Apr 30, 2020 in |
In the present investigation, some novel Mannich Bases of Pyrazoline derivatives(7a-g) is synthesized by treating various substituted acetophenones (1a-g) with 6-methaoxy-1-napthaldehyde (2) in alcoholic sodium hydroxide to obtained intermediate Chalcones (3a-g), which was further treated with isonicotinohydrazide (4) to get (3-(4-substituted phenyl)-5-(6-methoxy naphthalen-1-yl)-4, 5-dihydro- 1H-pyrazol-1-yl) (pyridin-4-yl) methanone (5a-g). Further, it is refluxed for 6-10 h. with 4-chloroaniline (6) and formaldehyde in methanol to afford Mannich Bases i.e. (4-(((4-chlorophenyl) amino) methyl) -5-(6-methoxynaphthalen -1-yl)-3-substituted phenyl-4, 5-dihydro- 1H-pyrazol-1–yl )(pyridin-4-yl) methanone (7a-g). The structure of synthesized Mannich bases was confirmed on the basis of Spectral data (IR, 1H NMR, mass, and elemental analysis) and evaluated for the antimicrobial activity. The antimicrobial data revealed that the synthesized derivative possesses very promising to moderate antibacterial and antifungal...
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