Posted by admin on Feb 29, 2020 in |
Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different aspect of anti-inflammatory and analgesic. The purpose of this study was to develop and evaluate bilayered tablets of curcumin for the effective treatment of inflammation. The Immediate-release layer was prepared by using superdisintegrants- SSG and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before the preparation of the tablets, all the pre-formulation parameters were checked and the tablet of curcumin were prepared by direct compression method and was evaluated for physical characteristics like hardness, weight variation, drug content and friability. In-vitro release of drug was performed USP type I dissolution test apparatus using 0.1N HCl...
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Posted by admin on Feb 29, 2020 in |
Despite years of intensive research, impairment in metabolic pathways due to type 2 diabetes mellitus continues to be a daunting global challenge. It is equally challenging problem in this region as well. In recent years there is growing clinical and experimental evidence that oxidative stress plays an important role in induction and promotion of diabetes and its associated complications. Lipid peroxides are known to be essential consequence of biological processes of excessive oxidative cellular damage can be a cause of consequences of numerous diseases, micro and macro complications of type 2 diabetes mellitus. There have been reports of elevated lipid peroxide levels in type 2 diabetes. To defend themselves against these free radical attacks, cell has developed different antioxidant systems. There are low molecular weight antioxidant molecules like uric acid, ascorbic acid, etc. and antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidases. Under physiological conditions, these defense mechanisms maintain a low steady-state concentration of free radicals in the cell and their activities are very precisely regulated. The levels of...
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Posted by admin on Feb 29, 2020 in |
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 patients of hypertension coming to the OPD of medicine of King George’s Medical University were enrolled in the study after screening and giving consent. The data from the prescription of the drugs were recorded in pre-specified case record forms and analyzed for drug utilization parameters. Results: The average number of drugs encountered per prescription was 4. Whereas prescriptions with the generic name were 38% and drugs from an essential drug list were found to be 74%. The most commonly prescribed antihypertensive group was calcium channel blocker (25.1%) in monotherapy followed by angiotensin receptor blocker (21.2%). In combination therapy, the most commonly prescribed combination was found to be calcium channel blocker + angiotensin receptor...
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Posted by admin on Feb 29, 2020 in |
Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against the other settling organisms. These seaweeds are an immense source of bioactive molecules for the exploration of novel drugs. The present investigation deals with the screening of phytochemical composition, fatty acid composition and antioxidant activity of the green edible seaweed Caulerpa lentillifera (Family: Caulerpaceae) (TSN: 6973 & APHIA ID: 211475). The seaweed was collected from Mandapam Coast, Tamil Nadu, different solvents were used for the preparation of seaweed extract. The Phytochemical constituents of seaweeds, such as carbohydrate, protein, tannins, phytosterols, glycosides, alkaloids, flavonoids, diterpenes, resins and saponins of C. lentillifera were analyzed using standard methods. Fatty acid profile was investigated using Gas chromatography Mass spectrometry (GC-MS). Various fatty acid components are analyzed using GC-MS and nearly 35 components were recorded. In the present investigation, the in-vitro analysis of antioxidant property has been confirmed. From this...
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Posted by admin on Feb 29, 2020 in |
Being exposed to a number of heavy metals in the environment, humans are suffering from various health problems. Cadmium and arsenic are both priority hazardous substances and carcinogens. Environmental co-exposure to these heavy metals is also an important consideration and most experiments with laboratory animals investigate only one heavy metal. In the present study albino rats were exposed to both the heavy metals alone and in combination in 5 groups and the 6th group was of control. Animals were treated for 30 days and 60 days with the lower doses of NaAsO2 (4.3 mg/ks b. wt.) in group B and CdCl2 (2.6 mg/kg b. wt.) in group D and higher dose of NaAsO2 (8.6 mg/ks b. wt.) in group C and CdCl2 (5.2 mg/kg b. wt.) in group E. A combination dose of CdCl2 (2.6 mg/kg b. wt.) and NaAsO2 (4.3 mg/ks b. wt.) was given to another group F of experimental animals. In 30 days, intoxicated animal groups the weights of the kidney, brain and heart increased and...
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