Posted by admin on Feb 29, 2020 in |
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on the, efforts being made to find out the prevalence of obesity over different anthropometrical and biochemical parameters. Anthropometrical parameters were considered in the school going children from families financially poor or with bound, while the biochemical parameters were performed on subjects from age group from 16 to 70 years. Many questions were asked in the form of a questionnaire related to their lifestyle. Anthropometrical data from school going children showed 11% obesity and overweight. Biochemical data showed 20.27% persons were having a TC level, 46.08% having HDL-c, 19.35% having LDL-c, 29.05% having TG, 36.48% having fasting glucose level and 37.18% having a postprandial glucose level higher than the threshold values. Henceforth, the results explained the...
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Posted by admin on Feb 29, 2020 in |
The objective of the present investigation was to develop topical curcuminoids containing gel as an anti-inflammatory. The first gel base was prepared by using various different concentrations of Carbopol 934, Propylene glycol 400, Methylparaben, Propylparaben, and required amount of distilled water. The optimized base was selected for the incorporation of different concentrations of curcuminoids (CM) and fixed concentration of tulsi oil (TO) and eucalyptus oil (EO). Then skin pH (6.8-7) was maintained by the dropwise addition of tri-ethanolamine. Prepared formulations were evaluated for physical appearance, pH, spreadability, viscosity, and homogeneity. Prepared formulations have proceeded for skin irritation on an animal model (rabbit). All gels were evaluated for anti-inflammatory activity by using carrageenan-induced rat paw edema model on Albino Wistar rats of either sex (150-200 gm). Change in edema volume of the rat hind paw was measured, and percent inhibition was calculated. Stability studies have carried out as per ICH guidelines for 3 months at different temperatures and humidity. Results reveal that all formulations have shown good appearance, homogeneity, and...
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Posted by admin on Feb 29, 2020 in |
The objective of the present study was to formulate and evaluate microspheres of Glipizide using guar gum and HPMC K4M as polymers for colon-specific delivery for better treatment of Type 2 diabetes. The glipizide microspheres were prepared by ionotropic gelation method by the use of various cross-linking agents. The microspheres were then studied for physical appearance, particle size, surface morphology, drug-polymer compatibility, and drug entrapment efficiency. The in-vitro drug release profile was studied in three different buffer medium using USP type I apparatus. Further, kinetic modeling was employed to find out the release mechanism. Glipizide microspheres showed high entrapment efficiency (89.80%) and the microspheres were free-flowing, non aggregated, and almost spherical between 500-700 μm in diameter. The FTIR spectrum showed that there is no interaction between the polymers and drug. The in-vitro release study found to be affected by using various cross-linking agents. The microspheres with barium chloride as cross-linking agents showing a small amount of drug release in acidic pH but show maximum drug release at the end...
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Posted by admin on Feb 29, 2020 in |
In the present study, the larvicidal activity of successive n-hexane, chloroform, ethyl acetate and ethanol extracts of Epaltes pygmaea DC (Family: Asteraceae) whole plant was carried out against three mosquito species namely Culex quinquefasciatus, Aedes aegypti L. and Anopheles stephensi. The crude whole plant was successively extracted with n-hexane, chloroform, ethyl acetate, and ethanol. The larvicidal activity was studied at 62.5 ppm, 125 ppm, 250 ppm, and 500 ppm concentrations against the late third instar larvae of C. quinquefasciatus, A. aegypti and A. stephensi. Results showed that the ethyl acetate extract of E. pygmaea was the most effective against tested mosquito larvae. The median lethal concentration (LC50) values of ethyl acetate extract were calculated as 35.79 ppm, 62.37 ppm and 29.94 ppm for C. quinquefasciatus, A. aegypti and A. stephensi, respectively. The results suggested that ethyl acetate extract of E. pygmaea could be used to control C. quinquefasciatus, A. aegypti and A....
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Posted by admin on Feb 29, 2020 in |
Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Tablets of quinapril hydrochloride were made by direct compression method. Microcrystalline cellulose was used as direct compressing agent. Sodium starch glycolate used as disintegrating agent and croscarmellose sodium used as super disintegrating agent. The resulting powder mixtures were then compressed into tablets using KBR machine. Dry coating using different concentrations of HPMCK4M, EC, and HPMCK100M. Also magnesium stearate and spray-dried lactose. Dry coated pulsatile tablet was prepared by placing 50% pulsatile release layer in 13 mm die and core tablet was placed on it. A1 to A 5 show less lag time, less in-vitro buoyancy study due to less concentration of polymer. Where A 7 gave drug release after 8 hours...
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