Posted by admin on Nov 30, 2020 in |
Chikungunya infection, caused by the flavivirus Chikungunya, spreads from one person to another by two species of Aedes mosquitoes, i.e., Aedes albopictus and A. aegypti. There is a rapid global emergence and resurgence of Chikungunya infections in India and the Indian Ocean Islands, making it a public health emergency around the globe. There are numerous strategies being adopted by this arbovirus to evade host immune defences, and as such specific preventive and therapeutic interventions to this fatal and incapacitating disease are still unavailable at large. Hence, under this grave global epidemiological scenario, the development of novel therapeutics against Chikungunya infections in humans is an absolute mandate now. Fortunately, in recent years, experimentations toward new approaches for the prevention and treatment of Chikungunya infections are already underway, with significant success being slowly achieved at the preliminary level of laboratory-based pilot-studies. In this article, we review some of these important advancements achieved in the development of novel chemical therapeutics, immunotherapies, vaccines, and complementary & alternative medicines against Chikungunya virus infections that have shown much promise and...
Read More
Posted by admin on Nov 30, 2020 in |
Eugenia uniflora known as pitanga or Surinam cherry, belongs to the Myrtaceae family and has essential nutrients that are prerequisites for human health. In the present study, Eugenia uniflora active fraction (EF18) that was obtained from the partial purification of crude ethanolic extract of Eugenia uniflora leaves were evaluated for its carbon tetrachloride (CCl4) induced liver toxicity in rats. Acute toxicity studies were carried out as per OECD-423 guidelines for identifying the correct and safe dose of EF18. Results of the present acute toxicity study showed that oral administration of dried up to the dosage of 2000 mg/kg was nontoxic. On the basis of the acute toxicity studies, two doses of EF18 were selected, a higher dose (500 mg/kg) and a lower dose (250 mg/kg). For the hepatotoxicity studies, Silymarin was used as a standard drug. In the study, EF18 significantly reduced the impact of CCl4 toxicity on the liver in a dose-dependent manner. Results of the histopathological analysis also support that EF18 can effectively reduce liver toxicity. The...
Read More
Posted by admin on Nov 30, 2020 in |
The main objective of the study was to develop an RP-UPLC method for the simultaneous determination and validation of the Daunorubicin and Cytarabine in the pharmaceutical dosage form. The technique was developed by using the Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile used in the ratio 50:50 v/v and X-Bridge C18 (2.1 × 100 mm, 1.6 µm) as a stationary phase at a flow rate of 0.3 ml/min. The buffer used in this method was 0.01N KH2PO4 (3.5 pH) buffer pH was accustomed by means of the solution of 0.1% OPA. The temperature was maintained throughout the method at 30°C, and the optimized wavelength chosen was 240.0 nm. The technique was developed and thoroughly validated based on the ICH (International Conference on Harmonization) guidelines. The validation process was done by precision, linearity, robustness studies, accuracy, Limit of Detection, Limit of quantification, and degradation studies. The robustness studies were observed by making variations in the mobile phase, temperature, and flow rate. The accuracy was observed at more than 96% recovery....
Read More
Posted by admin on Nov 30, 2020 in |
The present developed method was designed to fabricate an innovative, simple, cost-effective, and compatible method for controlled delivery of Metformin hydrochloride (MF) by the use of natural and synthetic polymers for comparative analysis. For the most commonly used anti-diabetic drug Metformin hydrochloride, we have tried to formulate microspheres by incorporating natural and synthetic polymers separately in order to identify the most appropriate and safe type of controlled drug delivery system. All the fabricated microspheres formulations were characterized for various evaluating parameters like percentage yield, particle size analysis, micromeretic study, entrapment efficiency of drug, in-vitro drug release, FTIR study, XRD analysis, and quantitative analysis of most optimized formulation by using high-performance liquid chromatography (HPLC) method. The formulations from F1to F5 were prepared by using natural polymer sodium alginate, by ion- gelation technique, and the formulation code from F6 to F10 represents microspheres formulated by using synthetic polymer by emulsion-solvent evaporation technique. It was observed that all prepared formulations showed improved flow behavior than a pure drug; on increasing the polymer...
Read More
Posted by admin on Nov 30, 2020 in |
Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of the world. Objective: To summarize updated information regarding the pharmacological activities of Muntingia calabura L. Materials and Method: Few databases like Google Scholar, Science Direct, and Pub Med were used for the literature survey. Google and Bing search also carried out using the common and scientific names of the plant as keywords. For reviewing, articles that are related to ecology and agriculture are excluded. And articles that were not in the English language were also excluded. Results: Above mentioned search engines yielded 47 articles. Among them, 17 articles which were published between 2015 and 2019 were selected for inclusion in this review. From the...
Read More
