Posted by admin on Oct 31, 2020 in |
Tecomella undulata (Sm.) seem is a monotypic genus belonging to family Bignoniaceae. The plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders, to name a few. The plant has gained prominence due to the presence of some prominent secondary metabolites. The present study focuses on the GC-MS analysis of extracts of all the plant parts of T. undulata, which revealed the presence of certain bioactive compounds like Quericitin, Kaempferol, stigmasterol, sitosterol, thiazoline, phytol, pthalic acid, methyl alpha ketopalmitate and so forth. A total of about 20 bioactive compounds were identified. The antimicrobial activity of the extracts was assayed against pathogenic bacteria and fungi. The flavonoids from leaf extracts showed highest antimicrobial activity against C. albicans, S. aureus, E. coli, and B. subtilis. This also correlates with the highest amount of Flavonoids present in leaves followed by the amount present in roots. The study thus infers that the presence of bioactive components may be the principle behind the...
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Posted by admin on Oct 31, 2020 in |
Psoriasis is a chronic inflammatory disease that affects about 1-2% population. It is caused by different factors, the most common cause being genetic predisposition. Other causes or factors that can trigger psoriasis include infection, physical trauma to the skin, stress and certain medication, for example, beta-blockers and antimalarials. People suffering from psoriasis are at a greater risk of developing psoriatic arthritis, anxiety, depression, and cardiovascular diseases. Psoriasis can affect the quality of life of the patients and can result in financial problems as repeated treatment is required. Nowadays, people now opt to make use of natural remedies alone or in conjunction with conventional therapy to improve their condition. In this review article, natural remedies that have proved to have antipsoriatic activity have been summarized. These natural sources can be a source of bioactive compounds that have a potential to treat and manage...
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Posted by admin on Oct 31, 2020 in |
A Simple, sensitive, specific and stability indicating RP-HPLC method was developed for the simultaneous estimation of velpatasvir and sofosbuvir in bulk and tablet dosage form. Effective separation attained by injecting 10 μL of the standard solution containing velpatasvir and sofosbuvir into Xbrdige Phenyl (250 × 4.6 mm, 5 µ, 100 A0) column, with a mobile phase containing methanol, buffer (0.1% formic acid in water) and acetonitrile in 40:30:30 v/v ratio, at a flow rate of 1ml/min. The eluted analytes were effectively responded qualitatively and quantitatively at 273 nm wavelength. The drugs were experienced in stress conditions such as oxidative, acid, base, photolytic, and thermal degradation. The retention times of sofosbuvir and velpatasvir were observed at 3.4 and 5.1 min, respectively. The method has a good linear response in the concentration range of 10-30 µg/ml and 40-120 µg/ml for velpatasvir and sofosbuvir respectively. LOD and LOQ were calculated as 1 µg/ml and 4 µg/ml for velpatasvir, 4 µg/ml, and 13 µg/ml for sofosbuvir. All the obtained validation parameters have been...
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Posted by admin on Oct 31, 2020 in |
Chenopodium album Linn. is a plant that has a long history of uses in liver disorders. This study was done to evaluate the hepatoprotective effects of methanolic extract of Chenopodium album leaves on paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect was evaluated on the basis of liver function parameters viz. Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline Phosphatase (ALP), Direct Bilirubin (DBIL), Total Bilirubin (TBIL) and Albumin (ALB) in serum of different groups of rats followed by histopathological study. In the present study, biochemical analysis suggested that acute administration of paracetamol-induced significant hepatotoxicity in experimental rats, which was evidenced by a significant increase in SGOT, SGPT, serum bilirubin, and serum alkaline phosphatase, while there was a decrease in serum albumin level. Treatment with C. album leaf extract has shown a marked reduction in SGOT, SGPT, serum bilirubin, and serum alkaline phosphatase, while there was an increase in the serum albumin level. The results of the present study revealed that the methanolic leaf extract of...
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Posted by admin on Oct 31, 2020 in |
The thyroid, an important part of the human endocrine system, is involved in the regulation of oxygen use, basal metabolic rate, cellular metabolism, and growth. As it acts as a regulator for the body, abnormalities of the thyroid should be reckoned with, and measures to prevent such occurrences should be followed. Hypothyroidism can be described as the inability of the thyroid gland to produce sufficient thyroid hormone to fulfill the metabolic demands of the body. Usage of medicinal plants and their active compounds for the treatment of diseases has, in recent years, showing a lot of promise in chemotherapy. Also, the lack of major side effects, as observed with the usage of such therapy led to an increase in the people’s tendency to use these compounds. In the present study, the effect of aqueous extracts of Terminalia chebula fruit on Thyroid parameters in rats during seven-day oral administration of a low dose of 250 mg/kg and a high dose of 500 mg/kg was investigated. The parameters evaluated the ameliorative...
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