Posted by admin on Sep 30, 2020 in |
About 1.5% of the world’s population is suffering from Parkinson’s disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in the striatum’s Substantia nigra & dopamine loss (DA). The disease of Parkinson is the second most widespread neurodegenerative disorder. It adversely affects the motor system as the disease increases the destruction of the motor system. It is also known that it also affects almost other components of the brain, but slowly. By using these animal models, we got to know the process of PD, its etiology, its pathology, molecular mechanisms, and numerous other disorders. Experimental models are carried out using theses different agents such as reserpine, 6-hydroxydopamine, haloperidol, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, and rotenone when used to produce particular PD characteristics. In addition, genetic models are also used to understand the processes in multicellular organisms such as drosophilia and zebrafish. Behavioral studies have been conducted mainly using these multicellular...
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Posted by admin on Sep 30, 2020 in |
The main objective of this research work is to develop biorelevant dissolution method for the Memantine extended-release capsule by correlating pre-prandial in-vivo performance. The mean plasma concentration profile obtained after oral administration of extended-release capsules was deconvoluted using the Wagner-Nelson deconvolution technique for deriving the percentage fraction of drug absorbed to achieve the target dissolution profile. The dissolution results obtained by using the office of generic drugs recommended dissolution method was not comparable with the target dissolution profile and observed with an F2 value of 30. Biorelevant dissolution method was developed using USP Apparatus 3 (reciprocating cylinder), with dissolution media simulating gastrointestinal tract sink condition. A full factorial design of the experiment was carried out for dissolution method development and optimization. Media volume and dips per minute were considered as main factors in the design of the experimental study. The developed biorelevant dissolution method based on statistical interpretation of the main effect, interaction effect, and desirability factor is with media volume 150 ml and 15 dips per minute and...
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Posted by admin on Sep 30, 2020 in |
Mosquito-borne diseases are serious health problems in India, and mosquito vector control is a fundamental approach to control various diseases. Essential oils represent eco-friendly alternatives to costly synthetic pesticides for mosquito control. The essential oil of Mentha spicata in India was used for its activity against Ae. aegypti. The essential oil showed pupicidal activity against this mosquito. The results indicated that essential oil from M. spicata induced 29, 49.5, 60.8, 67.76, and 81.36% mortality at 100, 200, 300, 400 and 500 ppm essential oil concentration, respectively. The essential oil was rich for various phytochemicals, including estragole, thymol, (-) – 8 – p – Menthen – 2 – yl, acetate, trans, and 3, 5-Heptadienal, 2-ethylidene-6-methyl-. This essential oil may serve as a low-cost vector control agent for mosquito-borne...
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Posted by admin on Sep 30, 2020 in |
Forskolin is a heterocyclic labdane-type diterpenoid extracted from the roots of the plant of Coleus forskohlii (Lamiaceae) has been studied in depth for its broad range of pharmacological properties. Coleus forskohlii aids in the control of pestilence of Uzi fly, Exorista sorbillans, and Exorista bombycis one of the gravest ecumenical pests in sericulture industry. Forskolin affected moulting; development and metamorphosis of Uzi fly and induced various types of morphological abnormalities in Uzi fly. The treated resultants of fifth instar Uzi fly maggots, a few of them died during moulting, some of them developed into maggot-pupal and pupal-adult intermediates, abnormal pupae, abnormal adults and remaining treated fifth instar maggots developed into morphologically normal adults exhibiting reduced fecundity when compared to the controls. Coleus forskohlii root extract (CFRE) exhibited growth-regulating activity on the Uzi fly. They affected pupal- adult transformation and produced intermediates along with ovarian deformities deformed adults and also affected the inhibition of pupation and adult emergence. The plant extract repressed the growth and development suggesting its use for...
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Posted by admin on Sep 30, 2020 in |
Quality is the most important requirement in the manufacturing process for every pharmaceutical and healthcare industry. All the drugs must be manufactured to the highest quality level. Quality cannot be guaranteed just by end-product testing, but we have to control each critical step carefully during the manufacturing process. This qualification and computer system validation plays an important role in controlling each critical step of application in order to maintain the quality of the final product. Computer system validation involves a series of activities that are taking place during the life cycle of processes. It also involves careful planning of various stages in the qualification and validation of application/software used in the manufacturing process, and all the work should be carried out in a structured way according to standardized working procedures. The objective of this work is to overview the qualification and computer system validation of instrument/equipment used in the pharmaceutical...
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