Posted by admin on Sep 30, 2020 in |
In the era of recent technology, robotic surgery will be the ruler of the medical world with its attributes, its journey from a mere idea to today’s world’s surgical epitome. Using the methods of telerobotic visualization and controlling systems, this technology works towards improvement in all the fields of medicine and patient care. Robotic surgery dwells on the functionality of the most widely known models of Da Vinci and Zeus. It has benefited the patients by combining with minimally invasive, transoral, and laparoscopic techniques working better in synergism. It has been to date employed in the surgeries in the fields of the eyes, cranium, bone, thyroid, heart, liver, obesity, gastrointestinal, obstetrics as well as carcinomas. Its future potential is bright based on the types of technologies that are being linked with normal robotic surgery. One such endeavour is the microbot, which makes reaching the smallest nooks and corners of the internal physiology of the human body possible as well as more...
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Posted by admin on Sep 30, 2020 in |
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and toxic side effects. The present study investigated the antiproliferative effects of Naraveliya zeylanica L. against the human lung cancer cell line A549. The cytotoxicity potential of ethanol extract of N. zeylanica was tested on A549 cell line by dose-dependent manner at concentrations ranging from 100-1000 µg/mL, and the viability of treated cells was evaluated by MTT assay. Different morphological changes in the cells and mode of cell death were analyzed by acridine orange/ethidium bromide (AO/EB) staining, single-cell gel electrophoresis (comet) assay and Hoechst staining methods. JC1 staining was adopted to check mitochondria-mediated apoptosis. Ethanol extract of N. zeylanica significantly inhibited the growth of lung cancer...
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Posted by admin on Sep 30, 2020 in |
This study is aimed at encapsulating Benzydamine Hydrochloride into nanosponges that involve different crosslinkers to polymers in the ratio of 1:1, 1:2, 2:3, etc., which are used, in order to protect these structures, to control their release and maintain their site-specificity. Emulsion Solvent Diffusion technique was applied for the formation of nanosponges, which were incorporated into carbopol hydrogel to give controlled release of the drug so that it adheres for a longer duration to the buccal mucosa and would gradually release the drug to give the desired release. The pre-formulatory DSC and FTIR study indicated there were no interactions of Benzydamine Hydrochloride (BZH) with excipients (Poly Vinyl Alcohol and Poloxamer 188). The formation of these nanosponges is confirmed through DSC, FTIR, FESEM, and TLC studies. BZH was loaded up to 88%, 85%, 72% w/w. Particle sizes of the loaded NS formulations were between 128 and 250 nm with low polydispersity indices of 0.6. Zeta potential was -17 to -150 mV, which gave a stable colloidal nanosuspension. Release studies were...
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Posted by admin on Sep 30, 2020 in |
The present work aimed to screen the phytochemical constituents and antibacterial activity in leaves of different extracts of Terminalia tomentosa (Combretaceae). Phytochemical analysis was performed to check the presence of flavonoids, alkaloids, phenolic compounds, steroids, saponins, tannins, anthocyanins, lignins, and glycosides. The antibacterial activity of aqueous, ethanol and methanol extracts of T. tomentosa was studied against gram-positive bacteria and gram-negative bacteria, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia. Alkaloids, flavonoids, phenolics, tannins, lignins, steroids, saponins, and glycosides were present in all the three extracts, whereas anthocyanidins were barred. Among the three fractions, ethanol has possessed the highest zone of inhibition on E. coli (19.8 mm), and the minimum inhibition zone was observed in aqueous against K. pneumonia (7.8 mm). In comparison with the extracts and counting with the antibiotics, ciprofloxacin (19-31 mm) has possessed the highest zone of inhibition. The obtained results of leaf extract are worthy for further studies to discover the unrevealed part of it and to prove its efficacy as an alternate for antibacterial...
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Posted by admin on Sep 30, 2020 in |
Varieties of natural products have been proved as a rich source of phytoconstituents which are reported for a wide range of therapeutic potential. Plumbago zeylanica L. Is one of the herbs which are traditionally used for its therapeutic value. It is reported for several bioactive chemical constituents like naphthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc. in its chemical composition. Plumbagin is one of the most bioactive compounds of Plumbago zeylanica L., which is reported for a wide range of pharmacological activities such as anti-cancer, anti-diabetic, anti-malarial, anti-microbial, etc. It is a naphthoquinone derived yellow crystalline phytochemical constituent which is well proven for cytotoxicity against various cancer cell lines both in-vitro and in-vivo. This study is aimed to review and highlight the anticancer potential of plumbagin, formulation development approaches, and issues in the dosage form design of Plumbago zeylanica L. and its isolated constituent...
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