Posted by admin on Aug 31, 2020 in |
Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the treatment of type 2 diabetes mellitus alone or in combination with the metformin or dipeptidyl peptidase-4 (DPP-4) inhibitors. The literature entitles the various analytical techniques like UV spectroscopy, High Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Liquid Chromatography-Mass spectrometry. In this literature, we reviewed the various analytical, stability studies, impurity profiling and bio-analytical methods used for the estimation of Empagliflozin. This review gives the concise and collective information about the analytical validating parameters like Limit of detection (LOD), Limit of Quantification (LOQ), Standard Curve, Accuracy & Precision for the analysis of Empagliflozin alone or in combination with the Linagliptin or Metformin. This review helps to carryout further analytical studies on the mentioned...
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Posted by admin on Aug 31, 2020 in |
The medicinal properties of Garlic are well known for a long time. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The present review article on garlic is to explore ancient phytomedicinal uses with modern scientific knowledge. Garlic cloves contain a colorless, odorless, soluble compound called alliin, water, and vascular enzyme alliinase. As soon as garlic clove is cut, alliin is converted to allicin by the action of enzyme alliinase. Pungent garlic smell is due to allicin. Modern scientific studies have revealed the beneficial effects of garlic on the cardiovascular system, Alzheimer’s disease, diabetes, wound healing, neuro/ nephroprotection, osteoporosis, stress, aging, and anti-fungal/bacterial/viral/ Protozoans. Though, it is commonly used in food items, yet it is also recommended as pesticide/insecticide/molluscicide. The present review deals with the diversified beneficial activity of the garlic in the welfare of human beings. Although recent researches on its medicinal properties had explored its therapeutic value in the treatment of various ailments, yet a lot...
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Posted by admin on Aug 31, 2020 in |
Asthma is a chronic disease; there is a need for a drug delivery system that maintains adequate therapeutic concentrations for a longer duration of action to improve better clinical efficacy. Salbutamol sulphate (SS) is a widely prescribed drug to treat asthma though it has short plasma half-life and undergoes extensive first-pass metabolism. Thus, it necessitates frequent administration by oral route to maintain adequate plasma concentrations. Hence an attempt was made to formulate and evaluate transdermal ethosomal gel formulations of SS to improve therapeutic efficiency and to reduce the dosage regimen. Ethosomal suspensions of drugs were prepared using phosphatidylcholine, alcohol, propylene glycol, and cholesterol. Then, suspensions were used to develop gels by incorporating them into carbopol. Formulations were evaluated for vesicular size, size distribution, scanning electron microscopy, drug content estimation, drug entrapment efficiency, in-vitro diffusion studies, Z-Average, polydispersity index (PDI), and zeta potential measurement. Analytical studies confirmed the absence of drug and polymer interaction. Drug content of ethosomal suspensions and gel formulations was found uniform, and microscopic images displayed that...
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Posted by admin on Aug 31, 2020 in |
The current studies details QbD enable the development of a simple, rapid, and cost-effective reverse phase high performance liquid chromatographic method for estimation of Acotiamide hydrochloride hydrate. The simple analytical RP-HPLC method was developed using Box-Behnken Design (BBD). In the present work, three independent factors were used, such as org phase (A), aqueous phase (B), and flow rate (C). Totally 17 experimental runs were suggested by the software for analyzing the interaction, and the tailing factor (R1), retention time (R2), and area (R3) were considered as response factors (dependent factors). The developed experimental design was statistically analyzed using ANOVA, counterplots, and surface response curves. The optimal chromatographic separation was achieved using Hyperchrom ODS C18 (4.6×250 mm, 5µ) analytical column with a mobile phase containing potassium dihydrogen phosphate buffer (pH 6.8): Acetonitrile (60:40 v/v) with the flow rate of 1 ml/min using PDA detector. The retention time of the drug was found to be 5.2646 min at a detection wavelength of 282 nm. The method was found to be linear in...
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Posted by admin on Aug 31, 2020 in |
Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produce bioactive compounds that can control microbial growth. Mangrove extracts can also be the likely sources of mosquito larvicides, antifungal, antiviral, anti-cancer, and anti-diabetic complexes. Mangrove endophytic fungi with promising antioxidant activities that may be useful to humans as novel physiological agents. The present review deals with the endophytic fungi from mangrove...
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