Posted by admin on Aug 31, 2020 in |
Increase in industrialization has raised the levels of heavy metal pollution in the country. In order to combat with this problem, many strategies were developed till date, and among them, the use of microorganisms is the most successful technique. The present study was undertaken for isolation, identification, and characterization of heavy metal (Cd) tolerant bacteria from industrial effluents of electroplating, steel and battery industry SAS Nagar, Punjab and Chandigarh (India). The effluents were initially tested for physicochemical parameters (BOD, COD, TDS, TSS, etc.).The cadmium content was quantified through spectrophotometric assay. Initially, a total of 20 bacterial isolates were isolated and screened, then the effect of selected strain on all the parameters of test samples was checked. On the basis of performance to cadmium tolerance, only two isolates were selected. These bacteria could tolerate cadmium up to 1000 ppm and 1500ppm. These isolated bacteria may be helpful for the bioremediation of heavy metal contaminated industrial...
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Posted by admin on Aug 31, 2020 in |
Dry Eye Syndrome is a common disorder of the normal tear film that results from one of the following: decreased tear production, excessive tear evaporation, an abnormality in the production of mucus or lipids normally found in the tear layer. Carboxymethylcellulose (CMC) is a highly viscous derivative of cellulose that is used as an eye lubricant. CMC moistens the eye to prevent or relieve dry eye and irritation. Emulgels are nothing but emulsions that may be of water-in-oil or oil-in-water type, which, when blended with gelling agents, gets jellified. Emulgels are a slight viscous product that creates the strength of the product to enhance the retention on eye and improve the spreadability of the product. Castor oil and CMC based emulgel were prepared in three different phases like Polymeric Phase (CMC and Carbomer), Oil Phase (Castor oil), and Aqueous Phase (excipient phase). Process variables also identified and design space created by varies the concentration of oil, surfactant, and polymer. Different formulations designed with changes in oil concentration from 0.25%...
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Posted by admin on Aug 31, 2020 in |
The irrational and repetitive use of synthetic chemical disinfectants can contribute to the emergence of resistant strains and represent a risk to health and the environment. The aim of this ethnobotanical survey, a first innovative study, is exploring for plants with disinfecting power. An ethnobotanical study was conducted among herbalists in Fez and Meknes cities located in the center of Morocco. Information covered includes the vernacular and scientific name of plants, used part, mode of preparation, and administration. A total of 13 species belonging to 8 families has been described. Lamiaceae and Asteraceae (23%) were the most representative with three species every one, followed by the Myrtaceae (14%) with two species. The other families (Cupressaceae, Caryophyllaceae, Rosaceae, Rutaceae, and Brassicaceae), were represented with the same percentage (8%), a specie for each family. The most recommended species are Lavandula spp. (61%), Origanum elongatum (33%), Arteminisia herba-alba (23%), Rosmarinus officinalis (17%), Eucalyptus spp (17%), Atractylis gummifera L. (16%), Citrus limon (8%), Anastatica hierochuntica (6 %), Myrtus communis L. and Rosa damascena...
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Posted by admin on Aug 31, 2020 in |
Novel coronavirus (nCovid-19) is a recent emerging, dangerous pathogen that has shaken the whole world. Present therapeutic strategies to deals with this infectious disease are only supportive. The discovery of a new drug within a short period of time is a great task. Structure predictions of several proteins associated with SARS-CoV-2, the virus that causes COVID-19, was made possible by Genomics. Docking is a computational method used in present days to identify a hit molecule by measuring the binding ability of molecular drugs within the binding pocket of the macromolecular target. In this study, we have selected five ligand molecules which are currently used as antiviral agents. The drugs selected are, namely, Acyclovir, Ganciclovir, Penciclovir, Valaciclovir, and deoxyguanosine. The protein with PDB id 6LU7 was retrieved from the protein data bank for the docking procedure. The 2D plot of interactions was obtained using discovery studio visualizer software, and energy calculations were done by summing up van der Waals, electrostatic, and Hydrogen bonding interactions. Acyclovir and its derivatives are found...
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Posted by admin on Aug 31, 2020 in |
Coumarin and its analogs have a wide range of attention in the treatment of hormone-dependent breast cancer by blocking the formation of estrogen through the inhibition of estrogen receptor. However, the Schiff bases are an important class of compounds with structural similarities of natural biological substances and also due to their presence of imine (-N=CH-), which have an impact on a biological system. Considering the above all facts, the present research work is aimed to design the series of building blocks of coumarin Schiff base moiety as target candidates for estrogen receptor. The designed molecules ensured their reliability through the in-silico drug designing model and subjected to a preliminary study by screening their violation of Lipinski rule of five, if any, predicted for their ADMET profile study by using online available tools. Later an attempt was made to synthesize the proposed compounds, and structural elucidation was done by IR, NMR, and Mass spectroscopy. Besides to this, an in-vitro cytotoxicity study by using human breast cancer cell lines also carried...
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