Posted by admin on Aug 31, 2020 in |
Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. Atenolol, an antihypertensive drug with a short half-life, limited bioavailability, unstable nature at basic pH potentiated the need for developing a gastro-retentive system, hence super porous hydrogel of Atenolol had been developed with cellulosic polymers, and adequate strength was imparted by the addition of Ac- Di- Sol. The structural morphology of hydrogel was investigated by SEM, and it was found that plenty of pores of different size ranges, like 1 µm, 2 µm, 10 µm were formed. Compatibility studies proved the integrity of the super porous hydrogel. Gelation time was found to vary with respect to the formulation. The setting time of super porous hydrogel was found to be increased with an increase in the concentration of HPMC K100M. The drug release from super porous hydrogels was sustained for 10 h. In-vitro...
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Posted by admin on Aug 31, 2020 in |
The nasal drug delivery system has been a promising route for delivery of proteins and peptides as it can avoid degradation in the gastrointestinal tract and metabolism by liver enzymes. However, due to the rapid mucociliary clearance, the bioavailability of proteins and peptides is still low. Hence, mucoadhesive microspheres may prolong the residence time of peptide drugs in nasal cavity and improve their absorption. In the present study chitosan microspheres loaded with a model peptide vancomycin hydrochloride were prepared. Drug-excipient compatibility studies were done to investigate and predict any possible interactions between the components in the formulation. The prime objective of the study was to check the influence of different process variables and formulation parameters on the two key parameters viz particle size and percentage entrapment efficiency of vancomycin loaded chitosan microspheres and to develop a formulation with desirable particle size for nasal delivery and with maximum possible entrapment efficiency. Drug-excipient compatibility study indicates that vancomycin hydrochloride is compatible with the polymer chitosan. Drug loaded chitosan microspheres were successfully...
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Posted by admin on Aug 31, 2020 in |
The present research was envisaged on the development of dry powder to treat asthma. Terbutaline sulphate (a bronchodilator) and Itraconazole (an antifungal) were used in the present study for bronchodilation and allergy to Aspergillus fumigatus (fungi) using lactose and trehalose as excipients. Dry powder insufflations were prepared by physical mixing (milling) and spray drying, out of which spray dried formulations with lactose as excipient gave the best results in-vitro. Hence, spray dried formulations were preceded for further pharmacokinetic and stability studies. The pulmonary concentrations of Terbutaline sulphate and Itraconazole from TER – A (sd), ITR – A (sd), TER: ITR – A (sd) monotonically decreased (Tmax = 0 min). However, Itraconazole showed higher AUC0-α in individual and combined formulation when compared to Terbutaline sulphate showing slower elimination of Itraconazole. From plasma pharmacokinetic data Tmax of Itraconazole formulations ITR – A (sd), TER: ITR – A (sd) was high when compared to the formulations of Terbutaline sulphate TER – A (sd), TER: ITR – A (sd) showing lower systemic bioavailability...
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Posted by admin on Aug 31, 2020 in |
Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2- (4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprofen, Oxaprozin, Ketoprofen, and Phenoprofen, aryl propionic acid derivatives play an important role in treating other symptoms. The possible improvements in the activity can be further achieved by slight modifications in the substituent on the basic aryl propionic acid. According to Grigoryan et al., 2019 studies reveal that the replacement of the carboxyl group by tetrazole ring, hydroxamate, ester, alcohol, and amide groups forms compound showing lower activity (anti-inflammatory, anti-nociceptive, ulcerogenic activity). The presence of a carboxyl group in the parent molecule of aryl propionic acid is important for broad-spectrum pharmacological activity. This review focused on recent advances and recent research on aryl propionic acid derivatives compared to medicinal...
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Posted by admin on Aug 31, 2020 in |
The late December of 2019 witnessed an outbreak of viral pneumonia of unknown etiology (VPUE) in the Wuhan city of Hubei province, China. Later it was identified as a novel strain of β-genus Coronavirus, which is similar to the Severe Acute Respiratory Syndrome (SARS) virus, which was a global pandemic during 2002-03. This novel coronavirus is rapidly spreading with an R0 of 2 and has an incubation period of 2-14 days. It spreads through human-to-human transmission and by fomites (articles and surfaces contaminated by affected persons). The World Health Organization acted immediately to prevent the spread of the virus by declaring it as a Public Health Emergency of International Concern (PHEIC). It has been declared as a pandemic, and several sets of guidelines have been issued by WHO, including social distancing norms and hygiene practices yet, this novel coronavirus continues to spread at an alarming rate leading to many fatalities across the globe. Since this novel coronavirus shares similar characteristics with other coronaviruses, some of the known treatment options...
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