Posted by admin on Jun 30, 2020 in |
The objective of the present study is to evaluate phytochemical composition and HPTLC finger print profile of medicinally useful plant Martynia annua L. (Martyniaceae) root extracts. The CAMAG HPTLC system was used for the finger print profiling of root extract using the mobile phase chloroform: Methanol (9:1 v/v). The profile showed that the root extract of Martynia annua exhibited several peaks with different Rf values when visualized at 254 nm and 366 nm. At 254 nm a total 7 peaks were observed and at 366 nm 9 peaks were observed. The result of HPTLC analysis of Martynia annua root extracts shows that the maximum number of chemical constituents present in alcoholic root extract of Martynia annua in comparison to hydro-alcoholic and aqueous root extract of Martynia annua in given solvent system of chloroform and methanol. Further bioactivity guided fractionation and analysis of isolated chemical entity can reveal the active constituents in the different root extract of Martynia...
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Posted by admin on Jun 30, 2020 in |
The contemporary development in the drug delivery system is a seamless process. Any delivery system targeting a molecule to a particular site is always been appreciated. This requirement can be fulfilled through a specialized drug delivery system that can easily target the drug at the site of action without compromising its efficacy and quality. Few new drugs typically cannot be effectually delivered by conventional dosage form. Hence, benefits from targeted, localized delivery of therapeutic agents are other driving forces for the current scenario. Nanosponge technology has been introduced to assist the release of drug in a controlled manner over time to reduce systemic toxicity and severe reactions. Nanosponges are tiny sponges with a size of about a virus (250 nm-1 μm), which consist of cavities that can be filled with a wide variety of hydrophilic as well as hydrophobic drugs, which can be further incorporated into a pharmaceutical dosage form such as oral, parenteral, topical or inhalation. The sighting of nanosponge has become a noteworthy step in overcoming certain...
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Posted by admin on Jun 30, 2020 in |
The objective of the work was to formulate a self-nanoemulsifying drug delivery system (SNEDDS) of zaltoprofen and to study the impact and interaction of various formulation variables on the formulation by the design of the experiment. A 13-run 3-factors, 3-levels box behnken design (BBD) was used for optimization with 1 replicates at the center point. The concentration of phosal 53 MCT, tween 80, and PEG 400 as oil, surfactant, and co-surfactant, respectively, were used as independent variables. Self emulsification time, % transmittance, and relative turbidity were chosen as responses for the study. Results obtained show the impact of independent variables on the response under study. The optimal concentrations of variables were found to be 27.71% (w/w) oil, 46.1% (w/w) surfactant and 19.28% (w/w) co-surfactant. The in vitro dissolution study showed a marked increase in dissolution rate than zaltoprofen powder. The box Behnken design was successfully used in the optimization of zaltoprofen SNEDDS and to study the impact of components on the response under study in a simplified and time-effective...
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Posted by admin on Jun 30, 2020 in |
Parkinson’s infection is a neurodegenerative issue portrayed by the cardinal manifestations of solidness, resting tremor, gradualness (bradykinesia) and decrease of development (hypokinesia). It is a maturing populace and in spite of the fact that there have been a few significant leaps forward as far as the treatment of this crippling illness, for example, drugs levodopa, dopamine [DA] agonists, anticholinergic and medical procedure. Parkinson’s ailment is an interminable, dynamic, neurodegenerative confusion with an expected pervasiveness of 31 to 328 per100, 000 individuals around the world. It is evaluated that more than 1 percent of the populace over age 65 are burdened with Parkinson’s infection, occurrence and pervasiveness increment with age. So, the point of the investigation to assess the impact of daidzein on Parkinson sickness instigated by the reserpine model in rodents. Reserpine is the antihypertensive specialist, incites the consumption of focal catecholamines stores. Infusion of reserpine in rodents causes hypokinesia, unbending nature, tremors, and idleness. Cell reinforcements assume a fundamental job in the avoidance or treatment of Parkinson infection,...
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Posted by admin on Jun 30, 2020 in |
Plants have great potential for the treatment and management of many diseases and have been used in many countries for the treatment of different diseased conditions. The medicinal value of plants lies in their bioactive phytochemical constituents that produce definite physiological actions in living beings. Many medicinal plants contain some chemical constituents that may cause harmful effects to humans if consumed in large quantities. Alkaloids occurring in large amounts could make plants poisonous despite its medicinal effects. Datura metel L., a member of the family Solanaceae, is known as Jimson weed and in Arabic known as “Jaozmasel”, is one of the well-known folk medicinal herbs with wide application, Chemical investigation of which revealed its components as alkaloids, carbohydrates, and proteins among which alkaloids including scopolamine, hyoscyamine and atropine are the main active ingredients that exhibits various activities, such as anti-asthmatic, sedative, analgesic and anti-rheumatoidal effects. Besides of medicinal usage, D. metel is one of the most abused plants all over the world because of its unrestricted availability, especially in...
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