Posted by admin on Jun 30, 2020 in |
Health may be defined as the capability to adapt and manage physical, mental, and social concerns throughout life. Oral health is a key indicator of overall health, wellbeing, and quality of life. WHO defines oral health as “a state of being free from chronic mouth and facial pain, oral and throat cancer, oral infection and sores, periodontal (gum) disease, tooth decay, tooth loss and other diseases and disorders that limit an individual’s capacity in biting, chewing, smiling, speaking and psychosocial wellbeing. Oral diseases are the most frequent non-communicable diseases (NCDs) and affecting humans lifelong, resulting in pain, malaise, malformation, and till death. Environmental pollution is now recognized as a global threat, and the actions of mankind are largely accountable for this. Various oral diseases like dental caries, fluorosis are influenced by the food and water quality in a particular topographic area. Chemicals in water can be both naturally occurring or introduced by human interference and can have a huge impact on teeth and oral mucosa. High concentrations of arsenic...
Read More
Posted by admin on Jun 30, 2020 in |
Parkinsonia aculeata (family – Caesalpiniaceae) is a large spinous shrub found in warmer regions of the world. It is a well known medicinal plant that has significant and promising biological activities such as antioxidant, anti-inflammatory, antidiabetic, antispermatogenic, etc. The phytochemical investigations of the leaves, flowers, and stem have revealed the presence of various glycosides, flavonoids, reducing sugars, alkaloids, sterols, tannins, volatile oils, and saponins. The various biological activities and potent phytoconstituents of the plant indicate its therapeutic potential efficacy. The present study shows the detailed investigation of the methanolic stem bark extract of the title plant. From the methanolic stem bark extract of the title plant 1-cyclohexyltridec-1-ene (new compound A), 6-hydroxypentacosylpentanoate (B), α-amyrin acetate (C), α-amyrin (D) and β-sitosterol (E) were isolated with the help of column chromatographic technique and characterized on the basis of different spectral studies i.e., 1H NMR, 13C NMR, IR, and Mass...
Read More
Posted by admin on Jun 30, 2020 in |
Microspheres are small spherical free-flowing particles, with diameters 1 μm to 1000 μm consisting of proteins or synthetic polymers which are biodegradable in nature. They are prepared to obtain prolonged or controlled drug delivery to improve, bioavailability, stability and to target the drug to a specific site at a predetermined rate. Microspheres are of various types and are prepared by different techniques as spray drying technique, solvent evaporation technique, single-emulsion technique, double-emulsion technique, etc. Microspheres do not receive much attention not only for prolonged-release but also for targeting of anticancer drugs. Microspheres can be applied in different fields as in cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others discussed in the review. In the future, with various other techniques microspheres will find a place in novel drug delivery, specifically in diseased cell sorting, diagnostics, genetic materials, safe, targeted & effective in-vivo delivery. The present review highlights various types of microspheres, different methods of preparation, its applications, and recent advances in microspherical drug delivery...
Read More
Posted by admin on Jun 30, 2020 in |
Carvedilol is a non-selective β blocker with α1 blocking activity used in the treatment of congestive heart failure, high blood pressure, and left ventricular dysfunction. Following administration by the oral route, it undergoes extensive first-pass metabolism resulting in low bioavailability of 25-35%. The aim of the present study was to incorporate carvedilol in bilayered chitosan containing mucoadhesive buccal patches to ensure unidirectional drug release. Buccal administration circumvents hepatic first-pass metabolism, as the drug directly enters into the systemic circulation through the buccal mucosa, thereby increasing systemic bioavailability. The patches were prepared using solvent casting method. Chitosan was used as a mucoadhesive polymer as well as the base matrix for the drug. To improve film properties of the patches, PVP was incorporated in all the formulations. An impermeable backing layer of ethylcellulose was used to ensure the unidirectional release of the drug. The compatibility of carvedilol and polymers was confirmed by DSC and FTIR. Bilayered patches were evaluated for various physicochemical parameters like appearance, weight and thickness, folding endurance, tensile...
Read More
Posted by admin on Jun 30, 2020 in |
A simple headspace gas chromatographic (HS-GC) method has been developed and validated for the simultaneous determination of residual solvents like methanol, methyl isobutyl ketone, cyclohexane and toluene in luliconazole by Flame ionization detector (FID). The separation was achieved on 30 m long DB-624 column, 0.53 mm in inner diameter, and 3.0 µm in film thickness. The headspace and chromatographic parameters like flow rate and oven temperature are optimized to enhance sensitivity and chromatographic resolution. Dimethyl sulfoxide is used as diluents, equilibration temperature of 80 °C for 5 min, programmed temperature in the range of 35 °C to 210 °C and nitrogen as the carrier gas was used. The developed headspace gas chromatographic method offers good symmetry and resolution for all the residual solvents. The proposed was found to be suitable for the determination of 4 different residual solvents. Validation results indicated that the method is specific, linear, precise, accurate, rugged, and robust, where recoveries ranged between...
Read More
