Posted by admin on May 31, 2020 in |
The reason for this exploration was to develop gastro-retentive drug delivery systems (GRDDS) of loratadine (LTD) to lengthen the gastric residence time (GRT) by using different polymers like hydroxypropyl methyl celluloses (i.e., HPMC K4 M, HPMC K15 M, HPMCK 100 M), xanthan gum and other excipients such as microcrystalline cellulose (MCC), sodium bicarbonate (NaHCO3), magnesium stearate. All LTD floating formulations (F1-F18) prepared by the direct compression technique and evaluated. Fourier Transformed Infrared Spectroscopy (FTIR) studies showed that there are no drug excipient interactions. All LTD effervescent floating matrix tablets (F1-F18) were assessed for various pre-and post-compression parameters like weight variation (mg), hardness (kg/cm2), thickness (mm), friability (%), drug content (%), in-vitro buoyancy (h), in-vivo buoyancy (h) and in-vitro dissolution (%) and resulted found within pharmacopoeial limits. The drug release and floating property depended upon the polymer type as well as polymer proportions. The floating lag time (FLT) and total floating time (TFT) of all prepared formulations (F1-F18) showed less than 90 seconds and ≥12 hours, respectively. The cumulative percentage...
Read More
Posted by admin on May 31, 2020 in |
Stability indicating the HPTLC method was developed for simultaneous estimation of teneligliptin and metformin by using aluminum plates precoated with silica gel 60 F224 (Merck) and mobile phase toluene: methanol: GAA: TEA (5:4:0.5:0.5) with scanning wavelength of 257 nm. The developed method was validated for linearity, stability, accuracy, precision, robustness, LOD and LOQ as per ICH guidelines. The proposed method was successfully applied for the assay of metformin and teneligliptin in dosage forms and results were found to be in an acceptable range with a labeled claim of the pharmaceutical dosage form. Linearity for metformin and teneligliptin was observed\with correlation coefficient (r2) value of 0.999 and 0.993. The proposed method was also applied for degradation study of dosage form in alkaline acidic, Thermal, and photolytic conditions. Further, kinetic degradation study in alkaline conditions (0.1 N, 0.5 N, 1.0 N NaOH) at 60 °C and 80 °C are carried out. The degradation rate constant was also predicted at different temperatures and strengths of NaOH using kinetic methods. Degraded product of...
Read More
Posted by admin on May 31, 2020 in |
The present study was designed to evaluate the in vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats. DOCA (10 mg/kg; i.p.) along with diet high in sodium chloride salt was used to induce hypertension in rats. Comparative effects of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits were observed. Female Albino rats (100-120 g) were divided into seven experimental groups (n = 6). Normal control, Verapamil standard control (50 mg/kg, p.o.), withacoagulin treatment groups (25, 50 mg/kg; p.o.), coagulin C treatment groups (25, 50 mg/kg; p.o.) and Toxic control (DOCA with 2% normal saline ad libitum). Rats having more than 150 mm Hg systolic blood pressure were chosen for the treatment. Noninvasive tail blood pressure amplifier (NIBP200A) was used to measure the blood pressure of conscious rats at a fixed interval of time every day for four weeks. A significant decrease (P< 0.05) in the blood pressure of withacoagulin treated and the standard group was observed....
Read More
Posted by admin on May 31, 2020 in |
Antioxidants are the substance having the potential to quench free radicals and significantly delay or inhibit oxidation of the substrate, thus protect biological systems against potentially harmful effects of free radicals; in low concentrations. The present study was aimed to evaluate the in-vitro antioxidant activity of Oldenlandia corymbosa L., a locally available medicinal plant of Assam, used as vegetable in diet and traditional medicine for liver disease and jaundice. The dried powdered plant material was extracted with 80% ethanol by Soxhlet extraction and was used for the fractionation in different solvents (methanol, petroleum ether, and ethyl acetate). The fractionated extracts were subjected to the analysis of in-vitro antioxidant activity with DPPH (2,2, Diphenyl-2-picryl hydrazyl), hydroxyl radical, nitric oxide, reducing power, and phosphomolybdenum assays for total antioxidant capacity. Ascorbic acid was used as standard at concentrations (20 μg/ml, 40 μg/ml, 60 μg/ml, 80 μg/ml and 100 μg/ml) dissolved in ethanol. Samples were prepared in the same manner. Results from in-vitro experiments revealed the significantly (p<0.05) high antioxidant activity in hydro-ethanolic...
Read More
Posted by admin on May 31, 2020 in |
Background: Lafutidine floating beads as a gastro-retentive dosage form antagonisms of histamine H2 receptor. It is used as anti-ulcerative agent. It is effective against the oesophageal lesions induced by acid reflux through inhibition of acid secretions. Objectives: The objective of the present work was to formulate and evaluate the floating beads of Lafutidine as a model drug. The objective of this study is to develop a simple uncomplicated and easy to manufacture floating beads that are capable of delivering lafutidine at a prolonged release rate of delivery. It has a short half-life (3 h). It has a low bioavailability (60-80%). The frequent dosing, which results in unacceptable patient compliance. Methods: Lafutidine was received as a gift sample and a thorough pre-formulation study was performed on a given sample in order to estimate the physicochemical properties like solubility, melting point, partition coefficient to confirm the authenticity of sample and to confirm that there are no significant barriers to the development of dosage forms. 12 different formulation of lafutidine floating alginate...
Read More
