Posted by admin on Mar 31, 2021 in |
Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicines are driving consumers towards herbal medicines and their supplements and this is driving the growth of Herbal Medicines across the world. Herbal Medicines, when sold commercially, should comply with country-based regulations concerning safety, quality, and efficacy. At present regulations for herbal medicines differ country-wise. Due to this, herbal medicine companies cannot manufacture a standard product for the global market. Hence a concerted effort should be undertaken by global regulatory authorities and agencies like WHO to establish a uniform and harmonized regulation for herbal medicines. In this paper, we highlighted various challenges and constraints in manufacturing as well as the marketing of herbal medicinal products across the...
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Posted by admin on Mar 31, 2021 in |
By the HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280 nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ± 0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intraday, and interday were found to be less than 2 prove the precision of the method. The correlation coefficient value from the calibration graph was found to be 0.9949 for Mebendazole and 0.9979 for Atorvastatin. The percentage protein binding of Mebendazole and Atorvastatin was estimated by the equilibrium dialysis method. The in-vitro displacement interaction study was carried out using standard solutions of a mixture containing 1.5×10-4 M Mebendazole and Atorvastatin along with 1.5×10-4 M BSA. The percentage protein binding of individual Mebendazole and Atorvastatin after 6hr was found to be 86.14% and 91.18%, respectively. While they were evaluated in the presence of each other, the...
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Posted by admin on Mar 31, 2021 in |
The present investigation was based on the development and evaluation of chronotropic capsules for hypertension treatment. Captopril has ACE inhibitor action to prevent the circadian rhythm related to hypertension. The solubility of captopril in the GI tract was pH-dependent i.e., captopril soluble only at 1.2 pH, show better stability, and absorbed in the upper part of the gastrointestinal tract. Captopril has 1-2 h half-life (t1/2) and 3.7 pKa value. For the optimization of formulation 32 factorial designs was used and in these methods, two independent variables at three levels were selected. The direct compression method was used for the preparation of pulsincap plugs. The dissolution profile of formulated batch F1 to F9 at the end of 9 h was found in the range of 92.50 to 99.60% in different pH of phosphate buffer. From the results, it was found that formulation F5 was shown the most similar dissolution profile because the similarity value was found to be above 90%. The swelling index was found higher in formulation F5 and...
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Posted by admin on Mar 31, 2021 in |
Introduction: Most potent toxic elements are derived from nature only. So safety and toxicological evaluation of plant extracts which are otherwise thought to be very safe, are mandatory. The zebrafish embryo has become an important model organism for toxicological research due to its small size, genetic similarity to humans, etc. The Objective: The objective of the present study is to determine acute toxicity that is lethal concentration fifty (LC50) of whole plant ethanolic extract of Amaranthus viridis (A1), Aerva sanguinolenta (A2) & Cynodon dactylon (A3) on Zebrafish (Danio rerio) embryos at a different time interval. Material and Method: Acute toxicity testing of the three whole plant ethanolic extracts A1, A2, A3 with six different concentrations each were performed according to OECD guideline 236 on Zebrafish embryos. Embryo development was monitored after 24 h interval for 120 h. After incubation, the living and dead embryos were evaluated using Light Microscope and images obtained with an optical camera. Statistical Analysis: LC50 values were calculated using the Probit method in the SPSS...
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Posted by admin on Mar 31, 2021 in |
Aims & Objective: To monitor therapeutic drug level of serum phenytoin for early posttraumatic seizure prophylaxis in traumatic brain injury (TBI) patients using enzyme multiplied immunoassay technique (EMIT) in a tertiary care hospital. Materials and Method: In this observational, open-label, non-interventional, prospective study, 90 patients of mild to moderate TBI patients were recruited, and serial monitoring of total serum phenytoin level along with concomitant serum albumin was done on day 3, 5, and 7 using EMIT assay. The monitoring of phenytoin drug levels along with Glasgow coma score and any episode of posttraumatic seizures was assessed. Results: The most common mode of injury was road traffic accidents (61.1%). Patients with total serum phenytoin level in sub-therapeutic level on days 3, 5, and 7 were 20%, 15.6 %, 14%, respectively. The toxic range % was 0%, 1.1%, and 7% on the three respective days. Conclusion: This observational study concludes that serial therapeutic drug monitoring (TDM) of phenytoin in TBI patients has the advantage of optimizing the drug level within the...
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