Posted by admin on Mar 31, 2021 in |
Currently, pharmacological activities of Eclipta alba (L.) plant extracts and individual phytoconstituents have revealed anticancer, hepatoprotective, snake venom neutralizing, anti-inflammatory and antimicrobial properties. The role of antioxidants is increasing day by day due to their multiple roles to reduce the harmful effects of oxidative stress. Phytoconstituents like wedelolactone and ursolic and oleanolic acids as well as luteolin and apigenin can form the basis of new drugs against cancer, arthritis, gastrointestinal disorders, skin diseases, and liver disorders. Plants have all these activities due to biologically active compounds, and for this, we have analyzed phytochemical screenings and antioxidant activity through the DPPH, ABTS●+, and reducing power assay and we got maximally phenols then flavonoids and flavonols and a good natural antioxidant agent. The best-known compound in E. alba i.e., Wedelolactone. It was analyzed by TLC, and it was present as 0.52 Rf value and present in pet ether extract and acetone extract and minimum in ethanol extract. The antioxidant activity was assessed through DPPH, ABTS●+ free radical scavenging activity and reducing...
Read More
Posted by admin on Feb 28, 2021 in |
In the synthesis of Nebivolol [a mixture of (1RS, 1′ RS)-1,1′-{(2RS, 2′ SR)-bis(6-fluoro 3, 4-dihydro-2H-1-benzopyran-2-yl)} -2,2′-iminodiethanol] having four chiral centers, one crucial isomeric impurity at 0.88 RRT was observed in HPLC related substance analysis in gradient HPLC method. This impurity was isolated from synthesized crude impurity substance by preparative HPLC with chiral normal phase and was elucidated as [(R)-1-[ (R)-6-Fluorochroman -2-yl]-2-({(R)-2- [(R)-6-Fluorochro man-2-yl] -2-hydroxyethyl} amino) ethanol] (R, R, R, R- Nebivolol) by means of chromatographic and spectral data. Structural elucidation carried out by spectral data was...
Read More
Posted by admin on Feb 28, 2021 in |
Antibiotic resistance emergence, as well as the Darwinism of up to the minute strains of ailment generating agents, is of grave concern to the global health community. Sustainable therapeutics of an ailment entails the amalgamation of contemporary pharmaceuticals or some potential prospective of novel drugs. Customarily employed medicative plants of Gopalganj community could be an enticing of drugs to fight this problem. This study is targeted at a reconnaissance of the antimicrobial properties of the plants that are customarily being used as traditional health implementation. The antimicrobial potential of five different plant extracts was screened against three pathogenic microorganisms, which were isolated from typical non-healing wounds of patients of Gopalganj district hospital. The microorganisms chosen to evaluate for antimicrobial activity were Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The favorable activity was shown by the extracts of Tridex procumbens L. was found to highest with zone of Inhibitions reaching to 18 mm, 19 mm and 20 they were nearly around the zone of inhibitions of positive...
Read More
Posted by admin on Feb 28, 2021 in |
Diabetes mellitus caused by inherited and/or acquired deficiency in insulin production or by the development of insulin resistance. This is chronic as well as moderately increasing day by day in developing countries as well as globally and has reached about to the epidemic ratio, and now it is a matter of worry for the populations. This deficiency results in increased blood glucose concentrations, which damages many of the body’s systems, in particular the blood vessels and nerves. There are several medications available for the disease. Worldwide, different drugs are prescribed in different manners as well as amount, which may cause severe side effects known as adverse drug reactions (ADRs). So, ADR monitoring is being an important task to reduce the damage by the drugs taken for the disease treatment. This study was performed for the ADRs monitoring of anti-diabetic medication in OPD of tertiary care hospital of northern...
Read More
Posted by admin on Feb 28, 2021 in |
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rather it is more about drug permeability and diffusion through different membranes. Curcumin as a drug candidate can be studied by considering various principal factors like rate, time, and location of the release of the drug with respect to its efficacy. It was found that the drug distribution is more at the kidney and liver than other organs due to substantial metabolism and elimination of drug at these sites. Due to its uneven, oversensitive, and non-bioavailable nature, additional clinical trials on curcumin are unwarranted. In fact, poor absorption, rapid metabolism, chemical instability, and quick systemic elimination anything could be a reason for poor bioavailability. The best possible solution for this problem is so narrow and lies somewhere around liposomal...
Read More
