Posted by admin on Feb 28, 2021 in |
This study seeks to evaluate the nephroprotective activity of chloroform extract of Abrus precatorius against gentamycin-induced nephrotoxicity in rats. Albino rats of Wistar strain of both sexes were used for the study and grouped into five, containing 6 animals. The study was performed for 14 days. For induction of nephrotoxicity, gentamycin and paracetamol were used, and the plant extract was given for 14 days. Later the animals were sacrificed, and kidneys were collected for histopathological studies. Meanwhile, blood was collected for estimation of serum parameters. All the animals treated with plant extract had shown decreased serum creatinine levels. The urea levels were also altered when compared to those of control. The histopathology studies of the kidney tissues also supported the results that the plant has a protective effect of gentamycin induced nephrotoxicity. The results of the study explored that the chloroform extract of Abrus precatorius has nephroprotective activity. Further studies are needed to isolate the active ingredients that have the protective...
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Posted by admin on Feb 28, 2021 in |
Mutual prodrugs of fenbufen and propyphenazone were synthesized with the aim of getting better therapeutic index through avoidance of gastrointestinal problems and to check the efficiency of release of parent drug in the presence of spacer. These mutual pro-drugs were synthesized by direct esterification and by using glycine as a spacer. The title compounds (FP1 & FP2) were characterized by spectral methods and the release of the parent drug from the mutual pro-drug was studied in two different non-enzymatic buffer solutions at pH 1.2 and pH 7.4. The biological activity of the title compounds (FP1 & FP2) was determined by tail-flick method, carrageenan-induced paw edema method, and ulcerogenic potential. From the results obtained it was concluded that these compounds exhibit better biological activity and less gastro-intestinal side effects than parent drug fenbufen. Both mutual prodrugs (FP1 & FP2) exhibited 42 and 32% respectively hydrolysis profile in buffer solutions of pH 7.4 and showed almost negligible hydrolysis i.e., 4.6 and 5.9 % respectively at pH 1.2 over a period of...
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Posted by admin on Feb 28, 2021 in |
Diagnosis of oral ulcerative lesions might be quite challenging. Oral ulcerative lesions were categorized into three major groups as acute, chronic, and recurrent ulcers. Helicobacter pylori (H. pylori) have been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. There is a close relation between H. pylori infection in the oral cavity and the stomach. H. pylori etiologic agent in recurrent apthous stomatitis, Canker sores. Quercetin inhibits the H. Pylori. Monoammonium glycyrrhizinate (MAG) was recognized as a compound possessing antimicrobial properties; MAG tested many researchers using the agar diffusion method which, show significant antibacterial activities against gram-positive (Bacillus subtilis, Stap Hylococcus aureus) as well as gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The objective of the present investigation was to formulate and evaluate gel for mouth ulcer treatment of Quercetin and MAG. The concentration of carbopol p940 and propylene glycol were optimized using a central composite design for two factors. Formulations were evaluated for various parameters such as pH, viscosity, spreadability, drug...
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Posted by admin on Feb 28, 2021 in |
Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for monitoring a normal mitochondrial function. Past years major discoveries have indicated that the characterization of fission and fusion is a little machinery, which is known as the physiological role of mitochondrial dynamics. Mitochondria (MND) and metabolic adjustments have been perceived as critical for growth movement. The numerous components of those organelles square measure in person connected to their morphology. Late confirmation proposes a significant association between mitochondrial (MNDL) construction and ill health, together with neurodegenerative, incendiary ailments and malignancy. Here, we scrutinize present-day movements within the perception of mitochondrial gestures with a special target with its liaison to cancer and therapeutic ways via synthetic and natural bioactive actives. Some notable compounds in the...
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Posted by admin on Feb 28, 2021 in |
“The Queen of Herbs” – Tulsi (Ocimum tenuiflorum), is the most sacred herb of India, also known as the holy Basil, is ubiquitous in Hindu tradition. Tulsi has been revered in India for over five thousand years as a healing balm for body, mind, and spirit. It is known to bestow an amazing number of health benefits. Modern scientific research offers impressive evidence that Tulsi reduces stress, enhances stamina, relieves inflammation, lowers cholesterol, eliminates toxins, protects against radiation, prevents gastric ulcers, lowers fevers, improves digestion, and provides a rich supply of antioxidants and other nutrients. Tulsi is especially effective in supporting the heart, blood vessels, liver, and lungs and also regulates blood pressure and blood sugar. In the present study, the preliminary phytochemical studies revealed the presence of secondary metabolites viz., alkaloids steroids, phenols, flavones, etc. The Pharmacognostic profile of this plant is also studied in detail and confirms the results of IHP and...
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