Posted by admin on Jan 31, 2021 in |
Moringa oleifera is widely used in Asia and Africa as an anti-inflammatory, anti-diabetic, and cold agent. However, there are no Moringa medicines on the Russian pharmaceutical market; therefore, it is of interest for research as a promising source of raw materials and introduction to the State Pharmacopoeia of Russian Federation. This study was conducted to compare the characteristics of the authenticity of leaves from different regions. Moringa whole leaf from India and powder from Namibia were studied using macroscopic, microscopic, and qualitative chemical analysis. The results showed that there are both similarities and differences of characters depending on the area of collection of raw materials. A quantitative assessment of diagnostic signs was carried out; for the first time, trichomes and druses, as well as stomata. Qualitative phytochemical analysis revealed the presence of tannins, flavonoids, and saponins in both samples. It was established that the studied samples corresponded to pharmacopoeial requirements for authenticity indicators. A relatively larger number of calcium oxalate druses was found in the Indian raw materials. The...
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Posted by admin on Jan 31, 2021 in |
Daclatasvir is an antiviral drug used in combination with other drugs includes sofosbuvir, ribavirin, and interferon, depending on the virus type to treat cirrhosis caused by hepatitis C (HCV). Several methods have been found for quantification, but those are not cost-effective, and they are time-consuming. The present study developed a simple, precise, accurate and cost-effective UPLC method to determine daclatasvir quantity in tablet dosage forms. A simple and selective UPLC method is described for the determination of Daclatasvir Chromatographic separation was achieved on a Acquity BEH C18 (50 × 3.0mm. 1.7 µm) using a mobile phase consisting 0.1% of Orthophosphoric acid: Acetonitrile in a ratio of 60:40 v/v with detection of 248 nm. Linearity was observed in the range 50-150 µg/ml for Daclatasvir (r2 = 1.000). The amount of drugs estimated by the proposed method was in good agreement with the label claim. The proposed method was validated as per ICH guidelines and applied for the determination of the cited drug in the dosage...
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Posted by admin on Jan 31, 2021 in |
Psoriasis is a skin disorder marked with inflammation. The development and progression of the disease are associated with a chronic inflammatory response, which is attributed to the dysregulated innate immune system. The dendritic cells and T cells secrete various cytokines leading to disturbances in the keratinocyte proliferation and differentiation. Several medications are available for the mitigation of psoriasis. The currently used anti-psoriatic medications are expensive; carry the threat of serious side-effects and frequent remission attacks of the disease. Exploring safer and effective anti-psoriatic drugs remains still a major concern. Natural products represent important treatment options for psoriasis. This review article discusses studies related to the topical formulations of anti-psoriatic plants and plant products. The pathogenesis and clinical symptoms of psoriasis include multiple immunological mechanisms and pro-inflammatory cytokines. The review aims to summarize the research done in this area and to explain the mechanism of action of herbal medicines. The review article is aimed at opening new medical approaches for treating psoriasis. All the findings suggested that various herbal constituents are responsible for anti-psoriatic activity. Herbal...
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Posted by admin on Jan 31, 2021 in |
A greenhouse and field experiment was conducted to investigate the effects of Azotobacter (Azotobacter chroococcum), Phosphate solubilizing bacteria (Pseudomonas fluorescens), and Arbuscular mycorrhiza-like fungi (Sebacinca vermifera) on seed germination, physiology, and essential oil production of dill (Anethum graveolens). The experimentation was comprised of a randomized complete block design with six replicates of each treatment. Evaluation of germination was done using parameters; germination percentage, mean germination time, germination index, T50 of germination, seedling vigour, and vigour index. Physiological responses include the parameters for total length, total fresh weight, and total dry weight of the plant. For physiological evaluation, harvesting of plants was done a total of four times at an interval of 30 days i.e. on 30, 60, 90, 120 days after transplantation. Essential oil analysis was done by hydrodistillation followed by Gas chromatography-Mass spectrometry. All the data collected were statistically analyzed using the GraphPad Prism v6 software package. Results showed that all treatments negatively affected the emergence behavior of seeds, whereas physiology of plants and essential oil production by...
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Posted by admin on Jan 31, 2021 in |
Inflammation, activated by oxidative stress, is the leading cause of all chronic diseases. Our culinary practices should include antioxidant and anti-inflammatory foods to combat these problems. Spices in India have been used traditionally not only as flavour enhancers in food but also as natural therapeutic agents in the prevention and treatment of a wide variety of ailments owing to the presence of an array of bioactive principles. The aim of the present study was to compare the in-vitro antioxidant, anti-inflammatory, and GC-MS profiles of Nigella sativa and Trigonella foenum-graecum seeds. In-vitro antioxidant and anti-inflammatory assays like DPPH (2, 2 – diphenyl – 1- picrylhydrazyl), Phosphomolybdenum, Ferric reducing antioxidant power, Superoxide radical scavenging assay, and Human Red Blood Cell stabilization assay was conducted to analyze the antioxidant and anti-inflammatory activities. Nigella sativa seeds were observed to have more antioxidant properties than Trigonella foenum-graecum seeds in all the assays. Maximum antioxidant potential was observed for Nigella sativa seeds in superoxide radical scavenging assay with lowest IC50 value of 17.28 µg/mL. The...
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