Posted by admin on Jan 31, 2021 in |
Co-crystallization is one of the most reliable alternative approaches to increase the solubility of poorly water-soluble drugs without affecting their physicochemical properties. Pharmaceutical cocrystals are neutral organic compounds connected to the API preferentially by loosely formed bonds as dipole-dipole interaction. Our present study aims at improving the solubility of an effective oral hypoglycemic, Glimepiride, a sulphonylurea class of drug that often lacks water solubility. In the process of enhancing its solubility, four different co-formers were used as Anthranilic acid, Succinic acid, Salicylic acid, Benzoic acid, and Gallic acid in different stoichiometric ratios like 1:2 and 1:3. The technique opted for the making is slow evaporation and prepare the nanoparticle by using Chitosan and gelatin polymeric matrix with aldehydic oxidized Xanthan gum as crosslinking agent. Initial confirmation was made through melting point determination. Later structure elucidation of co-crystals was carried out by several analytical methods, such as FTIR, X-ray Diffraction. In FTIR spectra, a sharp decrease in the intensity of N-H peak of salicylic acid and succinic acid was observed...
Read More
Posted by admin on Jan 31, 2021 in |
Medicinal plants are often used by humankind since their evolution. They are known to have prominent therapeutic potential. The present work is conducted on Glycosmis pentaphylla (Rutaceae) an ethnobotanically important medicinal plant rich in secondary metabolites. The plant possesses metabolites like alkaloids, flavonoids, terpenoids, etc., which can be used against various illnesses. The plant is traditionally used by the folklore people in many parts of the world. The aim of the study is to investigate the bioactive compounds present and to evaluate the significance of the therapeutic and pharmacological uses of the phytoconstituents. All the standard phytochemical and spectroscopic procedures were followed for the detection and estimation of phytoconstituents. The leaves, stem, and root of Glycosmis pentaphylla were collected and was extracted using various solvents based on their polarity. Preliminary phytochemical analysis reveals the occurrence of several secondary metabolites. The quantitative estimation exhibited the presence of secondary metabolites abundantly in leaves on comparison with stem and root. Further, an HPTLC analysis to determine the number of phytoconstituents was also...
Read More
Posted by admin on Jan 31, 2021 in |
A series of metal complexes, namely, Ni (II), Zn (II), Cu (II) and Pt (II), have been synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected to display DNA cleavage effect. Schiff base compoundof 2 – methyl – 3 – aminobenzopyrimidine – 4 – one (L1) was prepared by condensation of an equimolar mixture of 2-methyl-3-aminobenzopyrimidine-4-one (0.01 mole) and 2-hydroxybenzaldehyde (0.01 mole) in ethanol (25 ml). Schiff base (L2) compound was prepared by condensation of a mixture of Schiff base (1) (0.02 mole) and o-phenylenediamine (0.01 mole) in ethanol (25 ml) and a catalytic amount of KOH. The mixture was refluxed for 36 hrs. Ligand L2 (1 mmole) was dissolved in hot methanol. The metal chloride (1 mmole) was then added and the mixture was stirred under reflux for 24 h. The structures of ligands and their complexes have been confirmed by spectroscopic data i.e. IR, 1HNMR, MS, electronic and elemental (CHN) analysis. All Compounds were screened for DNA cleavage...
Read More
Posted by admin on Jan 31, 2021 in |
This present study aims to develop an accurate, precise, and linear reverse-phase High-Performance Liquid Chromatographic (RP-HPLC) method for the estimation of Pioglitazone HCL in Pharmaceutical dosage form. Method: The chromatographic system employs a reverse-phase Hypersil BDS, C8 250 × 4.6 mm, 5 columns using 0.01M Potassium phosphate buffer and acetonitrile (40:60) as mobile phase, methanol as a diluent in isocratic mode. A flow rate of 1.0 ml/min was optimized with a detection wavelength at 225 nm. The retention time (Rt) was around 4.72 ± 0.2 min. Results: The method was validated with respect to specificity, selectivity, linearity, accuracy, precision, and robustness as per ICH guidelines. The assay method was observed linear in the concentration range of 0.079-0.318 mg/ml with a Correlation coefficient (r2) of 0.9999. The percentage recovery of active pharmaceutical ingredients from tablet dosage form ranged from 99.40-100.40%. Stress conditions of degradation in acidic, alkaline, peroxide, thermal, and UV radiation were...
Read More
Posted by admin on Jan 31, 2021 in |
Last few eras, the remarkable advancement in the drug delivery system has been done; the oral route remains the important and picks up the safest route of drug delivery. Regardless of outstanding advancements in the oral route medication, the current study focused on the formulation of rebamipide SR tablets by studying several blends and their characteristics, including drug-excipients compatibility studies. Ultimately, it was concluded that it is safe to use PEO N12K, Camphor (milled), and MCC in the formulation of the Rebamipide Sustained release tablet. Thus, rebamipide Sustained-release tablets are successfully prepared by using conventional wet granulation technique requires making a matrix type tablet and displaying drug-release through diffusion mechanism. This formulation will assuredly improve patient adherence, improve bioavailability, low side-effects, and sustained clinical activity over the required duration of time (24 h) after single-dose administration. For the determination of the drug content in formulation, a simple, rapid, accurate, robust, and specific UV-Spectroscopy method was developed for the assay of the rebamipide sustained release tablet. The detection was carried...
Read More
