Posted by admin on Oct 31, 2021 in |
Background and purpose of the study: Propranolol hydro-chloride beta-adrenergic receptor antagonist utilized in the treatment of high blood pressure, atrial fibrillation, myocardial infarction, angina and migraine headaches. The pharmacokinetic parameters make Propranolol hydrochloride an appropriate candidate for oral disintegrating tablets. This work aims to develop orally disintegrating tablets for Propranolol hydrochloride and to evaluate their pre-compression, physicochemical properties and water absorption ratio, disintegrating time, wetting time, in-vitro dispersion, time, and in-vitro dissolution. Research rationale: To attain rapid disintegration, dissolution/absorption, and further improving the bioavailability of the drug. To resolve swallowing issues in geriatric, pediatric patients by rapid disintegration in saliva and to treat high blood pressure, angina, atrial fibrillation, myocardial infarction, migraine. Methods: Oral disintegrating tablets prepared by direct compression technique using super disintegrants like Crospovidone, Croscarmellose sodium, Sodium starch glycolate, and Pregelatinised starch in several concentrations. The prepared batches of tablets were evaluated for pre-compression parameters and weight variation, thickness, hardness, friability, drug content, wetting time, disintegrating time, in-vitro dispersion time and in-vitro dissolution. The physicochemical interaction between...
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Posted by admin on Oct 31, 2021 in |
A simple, sensitive and rapid chromatographic method was developed and validated for quantification of Mitomycin and Fluorouracil in bulk and pharmaceutical dosage form using Symmetry C18 (4.6 × 150 mm, 3.5 µ) column. The mobile phase consists of buffer, 0.1% Ortho Phosphoric acid (OPA), and acetonitrile in the ratio of 50:50 v/v. The flow rate is maintained as at 1.0 ml/min; detection was carried out by absorption at 260 nm using photodiode array detector. The calibration curve was linear and the regression coefficient (R2) value was found to be 0.999 and concentrations ranging from 10-150 µg/ml of mitomycin and 5-75 µg/ml of fluorouracil, respectively. The LOD and LOQ of the method were found to be 0.1 µg/ml, 0.05 µg/ml and 1 µg/ml, 0.5 µg/ml for Mitomycin and Fluorouracil. The number of theoretical plates and tailing factors for Mitomycin and Fluorouracil were not less than 2000 and were not more than 2, respectively. The developed method was found to be simple, economical, suitable and validated according to ICH...
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Posted by admin on Oct 31, 2021 in |
India is the fourth largest generic pharmaceutical market in the world. Indian pharmaceutical industries are very well established in today’s world and continuously producing a variety of products, which are useful in the treatment of various diseases and grabbing the market segments. India has a large number of resources to contribute vitality in the research and manufacturing process, and due to its large patient population & genetic pool, now it has become a region for cost-effective and speedy Clinical Trials (CTs) for Investigational New Drugs (INDs). Due to having these significant advantages, India now able to contract multinational pharmaceutical companies (MNPCs) to outsource operations in the fields of drug discovery and also able contract manufacturing and clinical research (CR) to organizations in India. On the other hand, understanding the regulatory scenario is not easy because the rapid and ongoing changes and the burden on the regulatory bodies to ensure a healthy supply of quality drugs at affordable prices to the population. The Indian pharmaceutical industry has shown impressive growth...
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Posted by admin on Oct 31, 2021 in |
Citrus fruit is a very rich source of Vitamin C, A, E, and flavonoids, alkaloids, and minerals. Citrus fruits are medicinal plants that present rutaceae family and include some fruits such as orange (Citrus sinensis), kinnow (Citrus reticulata), mosambi (Citrua ltmetta), grapefruit (Citrus maxima) lime, pomelo lemon. Antibacterial antiviral, antifungal activity of different solvent extracts (Acetone, ethanol, methanol, and distilled water) prepared by soxhlet extractor and aqueous solvent from three citrus fruit peel orange, kinnow, mosambi (Citrus sinensis, Citrus reticulata, and Citrus limetta respectively) were screened against four pathogenic bacteria staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi. The highest antibacterial activity was exhibited by the acetone peel and ethanol extract of Citrus reticulate peels. MICs were tested at concentrations ranging from 80-5.25 mg/mL as wells as their MBCs. The phytochemical analysis of the citrus peel extracts showed the presence of flavonoids, saponins, steroids, terpenoids, tannins and...
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Posted by admin on Oct 31, 2021 in |
Celiac disease an antibody-mediated enteropathy which is a lifelong condition where there is intolerance towards gluten. The only treatment till now is the gluten-free diet. The aim of this study was to investigate proximate, phytochemical and functional property analysis of gluten-free composite flour. The proximate analysis of composite flour for the most acceptable sample showed moisture (10.97±0.0), ash (3.35±0.2), fat (4.03±0.1), fiber (4.88±0.2) and protein (18.01±0.5), carbohydrate (61.72±0.4), respectively. Micronutrients like calcium (248.6±1.9), iron (5.03±0.9) and phosphorus (359.6±0.2), respectively, were also present in composite flour. Gluten content had been found 0.02 g/100g. This is the negligible amount that is allowable for celiac patients. The composite flour also contains several phytochemicals such as flavonoids, saponin, tannin, glycosides, alkaloids, and steroids. Some functional properties were assessed, namely water absorption capacity (WAC), oil absorption capacity (OAC), emulsion capacity (EC), foaming capacity (FC) and gelation capacity (GC). So this composite flour is useful for celiac patients and being nutritionally sufficient, conditions like anemia, diabetes and osteoporosis can also be prevented. Composite flour can...
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