Posted by admin on Aug 31, 2021 in |
Ayurveda (Indian system of medicine) chikitsapaddhati treats the patient with herbal, animal, and mineral drugs. Among the three, plant-based products acquire prime importance because of their wide utility and negligible side effects. Various parts of the plant are used solely or in different formulations. Niryasaor exudate broadly includes all types of secretory products like gum, resins and sometimes latex. From immemorial period niryasais being used in numerous disease conditions in Ayurveda but it is left unexplored so far. Hence, an effort is made to enlighten the path towards niryasa. Source, type of exudate, Rasa, Guna, Veerya, Vipaka and karma of several niryasa like Hingu, Dikamali, Srivesthaka, Dhava, Kankusttha, Vamshalochana, Garjanataila, Bola, Laksha, Bhimseni Kapoor, Aloe, Kunduru, Rala, Palasha, Khadira, Guggulu, Shigru, Rumimastagi, Sarja, Karpura, Gond kateera, Nimbaniryasa, Babbula, Arimeda, Mocharasa, Beejakaniryasa, Shilarasa, Tailaparni, Lobana, Charasand Raktaniryasaare tabulated as per available description in classics. Botanical identity along with illustration regarding exudate collection of above plants is catalogued based on published data from authorized journals. Apart from medicinal significance theyare also...
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Posted by admin on Aug 31, 2021 in |
Mesenchymal stem cells are a small number of undifferentiated cells located in various tissues of the body. They have the ability to self-renew and differentiate into lineages of mesenchymal origin. They serve as most promising candidates for various regenerative medicine and tissue engineering applications. Their use in various clinical applications depend on their proliferative capacity to expand cell population. One of the key challenge to expansion is decline in proliferation and differentiation capacity of cells isolated from older individuals. In the present study, we have compared cellular characteristics of bone marrow-derived mesenchymal stem cells isolated from young (4 – 6 weeks age) and old (60-64 weeks age) rats. The two rat groups were compared for proliferation kinetics, differentiation potential and senescence markers SA- βgal, reactive oxygen species (ROS), as well as expression ofP16INK4A, P21 and telomerase genes. A significant decrease in frequency, population doubling time, and cell yield associated with increase in age were observed. A decline in differentiation potential for osteogenic and chondrogenic lineages, and an enhancement in...
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Posted by admin on Aug 31, 2021 in |
Cyclea peltata (Lam), belonging to the family Menispermaceae, is a common plant in South India. It is mentioned in Ayurvedic classics by Rajapatha and is one of the important drugs used in Ayurveda therapeutics and is used widely in different formulations in medical practice. The quality control of crude herbal drugs and their bio constituents is paramount in justifying their acceptability. The crude drugs can be identified systematically on the basis of their morphological, histological, chemical, physical and biological studies. Phytochemical screening reported the presence of alkaloids, carbohydrates, glycosides, phyto sterols compounds and proteins and amino acids. The plant is widely used in the treatment of cough, fever, kidney disorder, urinary disorder and snake poisoning. The aim of the present study is to extract and isolation of bioactive compound (Thymol) from Cyclea peltate (Lam) Hook f. Thoms, the isolation and characterization analysis, included Thin Layer Chromatography, High-Performance Thin Layer Chromatography, GC-MS and Spectroscopy studies (IR, NMR and MASS). The presence of thymol in the ethanolic fraction revealed that the...
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Posted by admin on Aug 31, 2021 in |
Plants present in the mangrove ecosystem are underexplored for their natural bioactive agents, including a neglected scope of inventing newer antimicrobials, to combat global crisis mediated by MDR microorganisms. In this study, we investigated four plants-Excoecaria agallocha, Bruguiera gymnorhiza, Avicennia alba and Aegialitis rotundifolia of the Sundarbans, world’s largest mangrove ecosystem in West Bengal, India, for their antimicrobial activities against Salmonella typhi and Candida parapsilosis, in addition to their important bioactive resources including antioxidants. Ethanolic, methanolic, and DMSO extracts of leaves of these plants were studied by antimicrobial screening, determination of total phenolic and flavonoid contents, DPPH free radical scavenging activity, ABTS [2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] assay, ferric reducing antioxidant power (FRAP), lipid peroxidation inhibition, thin layer chromatography, and liquid chromatography-mass spectroscopy (LC-MS). E. agallocha extracts showed excellent antimicrobial activities against S. typhi, while antifungal activity against C. parapsilosis was almost lacking. MIC values of all the extracts against S. typhi was as low as 3.96 µg/mL, however, growth inhibition was most with E. agallocha extract. Again total phenolic content...
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Posted by admin on Aug 31, 2021 in |
Triazole is a diunsaturated heterocyclic compound that contains two nitrogen groups as heteroatoms. In the present study, an attempt was made to synthesize various derivatives of substituted 1, 2, 4-triazol-3-yl) benzene-1-ol and assess their antimicrobial efficiency. The synthesized compounds were subjected to physical characterization and spectral analysis by IR and NMR for structure elucidation. The compounds were then subjected to evaluation of antimicrobial activity against bacterial strains Escherichia coli (Gram -ve), Pseudomonas aeruginosa (Gram -ve), Bacillus Subtili (Gram +ve), Staphylococcus aureus (Gram +ve) method using ciprofloxacin as standard and against fungal strain Aspergillus niger method using fluconazole as standard. The results of antibacterial activity show that compounds P1 and P2 and the results of antifungal activity show that compounds P3 and P4 showed equivalent activity when compared with standard while the rest of the compounds were found to be less active than...
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