Posted by admin on Jul 31, 2021 in |
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resources to inform future introductions of PCV and any other new vaccine in other states of India and internationally. Methods The process of PCV introduction in Haryana was introduced with the launch of “Atal Jeevan Rakshak Teekakaran Yojna,” in 22 districts of the Haryana. The highest political and administrative leadership with a strong commitment to reducing the IMR and U5MR, approved the proposal and budget (~12 million USD). It was planned use of the of PCV13, and follow the National Immunization schedule i.e. 2 primary and 1 booster dose at 6, 14 weeks, and 9 months. The State-level launch ceremony of PCV introduction was organized in November 2018. Findings: Haryana became the...
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Posted by admin on Jul 31, 2021 in |
Background: World Health Organization states that antibacterial/antimicrobial resistance (AMR) can threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. Objective: This review aims to discuss the plants and their derivatives having anti-corona virus/ viral activity. Methods: For the preparation of this review article, all the relevant information was gathered from accessible and inaccessible resources (Web, Books, Thesis, etc.). Results: It has been accepted worldwide that the uses of herbal products provide stronger immunity which helps to fight against these microbial species. SARS- CoV2 virus is now a pandemic, affecting many countries around the globe. This long series of herbal species may interfere with the target-specific proteins named S Protein, S protein- ACE-2 interaction, Helicase protein, N Protein, 3CLpr, PL pro to prevent the viral replication in the host. Traditional herbal medicine not only inhibits the virus attachment to the host body but also prevents replication and boosts up the host immune system. Natural remedies reduce the viral load and,...
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Posted by admin on Jul 31, 2021 in |
Amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease occur as a result of the neurodegeneration process. No specific treatment was found to reduce or stop neurodegenerative diseases. In conventional medicine, many plants have been used to treat neurodegenerative diseases. Natural products play an important role in the prevention and treatment of various neurodegenerative diseases, as well as neuronal dysfunction. Different studies suggest that natural products, such as polyphenolic and plant-separated alkaloids, may delay neurodegeneration and improve memory and cognitive function. Ethnopharmacological studies have provided data to identify potential new drugs in plant sources. Recently many drugs found in medicines have been isolated from plants or their origin, including anticholinesterase (Anti-ChE) isolated plant alkaloids that have been investigated in terms of their potential in the treatment of Alzheimer’s disease (AD). The anti-inflammatory and antioxidant activities of plants and soluble components of plants are used to improve inflammation, anxiety, seizures, and more. Medicinal plants have beneficial properties due to the presence of complex chemical compounds to treat toxins...
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Posted by admin on Jul 31, 2021 in |
Colon carcinogenesis is a multistep process that arises by the accretion of genetic alterations. The genetic and epigenetic changes which transform normal colonic epithelium into aberrant crypt foci which is responsible for penetration. The GC-MS analysis of ethanolic extract of Epiphyllum oxypetalum (DC.) have shown the presence of phenolic compound (4-hydroxy-2-methylacetophenone), Diterpene, steroids which were reported for antioxidant and anticancer activity. In the present study Brine shrimp lethality, Trypan blue assay, and MTT assay in-vitro models are performed. In an in-vivo study, animals were divided into 5 groups as Normal, Control (NMU + distilled water 10ml/kg.), Standard (5-Flurouracil with the dose of 10mg/kg via intraperitoneal route given once in a 3 days of interval for 15 days to complete 5 cycles.), Test I (100mg/kg absolute ethanol extract of leaves of plant Epiphyllum oxypetalum (DC.)) and Test II (200mg/kg absolute ethanol extract of leaves of plant Epiphyllum oxypetalum (DC.)) groups each group comprised 6 animals. Cancer were induced in rats by using N-Methylnitrosourea by intra-rectal instillation method in a dose of 0.4% solution...
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Posted by admin on Jul 31, 2021 in |
Background: This was a conventional comparative treatment-controlled study designed to analyze the effect of dopamine infusion in the treatment of prerenal azotemia (PRA). Material and Methods: thirty randomized consecutive adult patients (group A= 15, B=15) aged 18 and 58 years with PRA were recruited. Group a received conventional treatment only (fluid replacement and frusemide), while group B received conventional treatment and dopamine. 24 hours urine volume, hemodynamic changes (pulse and blood pressure), serum electrolyte, urea, and creatinine were measured for the first 5 days of hospitalization. Duration of oliguria and hospitalization, mortality, number of patients who developed acute tubular necrosis (ATN), and or required dialysis was computed. Results: Duration of oliguria and hospitalization were shorter in group B than in group A patients (P = 0.025). The daily and hourly urine output was more in group B than in group A patients (P = 0.025). However, from the second day, patients in group B excreted more sodium than patients in group A (P = 0.001). 5 patients in group...
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