Posted by admin on Jul 31, 2021 in |
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The optimum therapy only results when the right amount of drug is delivered to the right targeted organ at the most suitable time. The present research aimed to develop a chronotherapeutic drug delivery system of combination drugs using mini-tablets technology, which can be administered at bedtime and releases Amlodipine within 2 h followed by the rapid release of Losartan after the lag time of 6 h. The developed mini-tablets were evaluated for compatibility studies, pre-and post-compression parameters. The compatibility studies indicate no chemical reaction, pre-compression parameters indicate good flow properties, and post-compression parameters were within limits. The obtained results of in-vitro studies have shown that Amlodipine and Losartan were not...
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Posted by admin on Jul 31, 2021 in |
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond interactions lead to the identification of active binding sites of P2Y12 protein in the docked complex, signifying the affection of active Metabolite of Prasugrel is more than other active metabolites of ticlopidine and clopidrogrel. The present study may lead to the discovery of therapeutically potent agents against clinically very important cardiovascular disorders, including arterial thrombosis, Hypertension, embolism etc. cardiac diseases. Hence the computer-aided drug design docking model proposed in this work can be employed to design the metabolites of Clopidogrel, Prasugrel, and Ticlopidine with specific P2Y12 inhibitory activity and futuristic active metabolites...
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Posted by admin on Jul 31, 2021 in |
Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4-hydroxy-3-((4-hydroxy-2-oxo-2H-chromen-3-yl)(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-2H-chromen-2-one (4a) and 4-hydroxy-3-((4-hydroxy-2-oxo-2H-chromen-3-yl)(1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)methyl)-2H-chromen-2-one (4b) were synthesized using lanthanum nitrate hexahydrate (La(NO3).6H2O) and nickel dichloride hexahydrate (NiCl2.6H2O). The synthesized complexes 5a-d were isolated and characterized by IR, Mass, and 1HNMR spectroscopy. The spectra of complexes 5a-d were interpreted on the basis of comparison with the spectrum of the free ligand. These complexes were screened for DNA photocleavage activity. Two complexes, 5a, and 5b, gave significantly good results found to degrade both forms of DNA (SC and NC). Our data give the reason to conclude that these compounds can act as lead compounds and should be submitted to further more detailed biological...
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Posted by admin on Jul 31, 2021 in |
An accurate, precise, and simple stability-indicating and RP-HPLC method was developed and validated for the estimation of Remogliflozin Etabonate in bulk and pharmaceutical dosage forms. Primacel C18 (150 × 4.6mm, 5µm) column, with mobile phase Acetonitrile: Water (70:30, v/v) at isocratic mode, was used for the development of this method. At wavelength 280nm, and flow rate of 1ml/min was maintained. The retention time for remogliflozin etabonate was about 2.6 min. This method was validated with respect to ICH guidelines for linearity, the limit of detection, the limit of quantification, precision, accuracy, robustness, solution stability, and forced degradation studies. Linearity was performed in the concentration range of 25µg/ml to 150µg/ml with a correlation coefficient of 0.999. The percentage recovery for Remogliflozin Etabonate was found to be within limits of 98% – 102%. The %RSD was also found to be less than 2% which is within limits. Forced degradation studies result in maximum degradation occurred in alkali, acid, and peroxide degradation studies. There was no degradation occurred in photolytic and thermal...
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Posted by admin on Jul 31, 2021 in |
Nanoparticles are being constantly exploited by the scientific community due to their versatile properties and applications. However, the synthesis of metallic nanoparticles achieved through conventional physical and chemical techniques is quite expensive and a labor-intensive process with serious consequences like instability of nanoparticles and toxic byproducts. Hence, green synthesis utilizing biological systems, including plants, bacteria, yeast, fungi, and algae proves to be a cost-effective and eco-friendly alternative. Plant extracts are a rich source of many bioactive compounds like secondary metabolites and often act as reducing and capping agents in the synthesis of nanoparticles. The present work deals with the synthesis of silver nanoparticles using aqueous leaf extract of Sauropus androgynous. Prior to the synthesis, phytochemical analysis and antioxidant potential were evaluated. Physical parameters, including silver metal ion concentration and the temperature were optimized for the effective synthesis of silver nanoparticles. The synthesized nanoparticles were characterized via UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray crystallography (XRD). Finally, silver nanoparticles were evaluated for their antibacterial...
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