Posted by admin on Nov 30, 2021 in |
Beta-blockers are widely used in combination with Ivabradine in people with coronary heart disease (CHD), one of the leading causes of death. Thus, monitoring of these drugs is important because it is accessible to manage heart failure amongst people with CHD. In addition, its quality control is fundamental to provide quality medicines. Method of analysis can be the first step in the rational use of pharmaceuticals. In this context, a detailed study of literature and official compendia for the pharmaceutical quality control of Ivabradine and Metoprolol were done. Among the analytical methods in the evaluation of Ivabradine and Metoprolol, HPLC is predominantly followed by HPTLC and UV. It was found that in the literature that analysis of Ivabradine and Metoprolol-based pharmaceutical products are more common than analysis of Ivabradine and Metoprolol in biological matrices. Pharmaceutical analyses have an impact on analytical decisions as well as effective and reliable results. The method must be suitable for the intended investigation. Although, there is a lack of Analytical Methods for estimation of...
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Posted by admin on Nov 30, 2021 in |
The present study evaluated the antimicrobial and cytotoxic activities of chloroform, hexane methanol, and petroleum ether extracts of Plumbago zeylanica (PEC, PEH, PEM, and PEP). Antimicrobial activities of the extracts were evaluated against gram-positive bacteria (Staphylococcus aureus-ATCC 6538 and Bacillus cereus-NCIM 2155) and gram-negative bacteria (E. coli-ATCC 8739) along with cytotoxicity activity against cervix carcinoma cell lines (HeLa and SiHa cell lines). Out of the four extracts tested, PEM and PEC extracts showed significantly high value of zone of inhibition against tested bacteria. PEM showed zone of inhibition of 10 mm, 13mm and 8 mm in ATCC 6538, NCIM 2155 and ATCC 8739, respectively. On the other hand, chloroform extract showed a zone of inhibition of 8mm, 10mm and 7 mm in ATCC 6538, NCIM 2155 and ATCC 8739, respectively. The four extracts PEC, PEH, PEM, and PEP showed a significant cytotoxicity activity with IC50 concentration at 238.93ug/ml, 694.44ug/ml, 580.40ug/ml and 593.04ug/ml against the HeLa Cell line and 142.71ug/ml, 547.16ug/ml, 448.04ug/ml and 424.27ug/ml respectively against the SiHa Cell line...
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Posted by admin on Nov 30, 2021 in |
Cryptococcus neoformans and Candida albicans are the major causative agents for infections, cryptococcosis, and candidiasis in human. Anti-fungal drugs for the treatment of fungal infections may show less effective activity on the pathogens due to the poor absorption or inadequate drug distribution, and some pathogens may evolve anti-fungal drug resistance. The development of anti-fungal drugs from natural sources with potential activity is of main global concern. Some filamentous fungi themselves can secrete anti-fungal compounds, which show effective antagonism against numerous pathogens. One such fungus, Aspergillus giganteus is known to produce anti-fungal proteins (AFP). In this study, the AFP is purified and its antagonistic activity was determined by analyzing its pathogenic membrane disruption ability. Extracellular pH and the lipid level in the AFP treated pathogenic cell membrane were also evaluated. The results have proved the membrane damage and disintegration of the pathogenic cell membrane by AFP and were observed in a dose-time-dependent manner. The fluctuation in the extracellular pH was monitored in the treated pathogens. This study has identified a...
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Posted by admin on Nov 30, 2021 in |
Olmesartan Medoxomil and Cilnidipine combination lowers blood pressure effectively. Olmesartan Medoxomil is an angiotensin receptor blocker (ARB), and Cilnidipine is a calcium channel blocker (CCB). Cilnidipine and Olmesartan Medoxomil are widely used in hypertension. The scope of the study is to optimize the chromatographic conditions to develop a new RP-UPLC method for the simultaneous estimation of Olmesartan Medoxomil and Clinidipine, which is simple, accurate, precise, and rapid. A very few methods were developed by UPLC using DAD. The mobile phase used is 0.5% w/v Ammonium acetate buffer: methanol: Acetonitrile (40:50:10), and the detection was carried out at 240 nm by using PDA detector. The flow rate was optimized at 0.4ml/min. The retention time was found to be 0.587 and 0.992 for Olmesartan Medoxomil and Cilnidipine, respectively. All the parameters of the method development and validation meet the ICH guidelines criteria. Thus the work establishes that the reported method is more economical and can be regularly used in practical application for simultaneous analysis of the Cilnidipine (CIL) and Olmesartan medoxomil...
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Posted by admin on Nov 30, 2021 in |
Hydrogels were the primary biomaterials developed for human use. Hydrogels are playing an increasing role in regenerative medicine attributable to their growing functional sophistication. Polymer scaffolds have many diverse applications within the field of drug delivery, tissue engineering, and implantation. They are used as dispensing devices for bioactive molecules and as three-dimensional (3D) structures that provide stimulants that organize the cells and guide the desired original tissue development. Hydrogels are used as a scaffolding material since they are structurally identical to the extracellular matrix of various tissues, mostly manufactured under mild conditions, and can be introduced in a minimally invasive way. Hydrogel materials formed a gaggle of polymeric materials. The hydrophilic arrangement enables them to retain huge amounts of water in their three-dimensional (3D) backbone. As a result, hydrogels are used as scaffolding substrates for delivery of the drug and growth factor transmission, modifications in tissue engineering, and many other applications. In this review, we describe the properties of hydrogels, types of polymers, classification, fabrication methods and...
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