Posted by admin on Jun 30, 2021 in |
Schiff base was prepared by using 4-amino-3-hydroxy benzoic acid and 4-nitrobenzaldehyde, namely (E)-3-hydroxy-4-((4-nitrobenzylidene) amino)benzoic acid. In the preparation of rare earth complexes, nitrates of lanthanum, Cerium, and Praseodymium were used with Schiff base. Rare earth Schiff base complexes were prepared by using NaOH to maintain the pH of solvent. Synthesized Schiff base ligand and its complexes were structurally characterized by UV, IR, NMR, HRMS, TGA, and elemental analysis. Structural characterization shows 1:2 metal to ligand ratio in the complexes. The electronic absorption spectra of the ligands and their metal complexes are recorded after preparing the solution and after standing the solution for 3 weeks in DMF. No appreciable change was observed in the spectrum with time. Free ligands and their metal complexes have different electronic spectra’s and blue shift observed in complexes which support the complex formation. HRMS are in good agreement with calculated values, which confirms the proposed structure of ligand. Carboxylate group of Schiff base ligand shows bidentate the coordination to central metal and azomethine group is...
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Posted by admin on Jun 30, 2021 in |
In the present research worked aims to increase the antimicrobial activity of quinoxaline thiosemicarbazide derivatives by substitution of some acetophenones and their antimicrobial evaluation against various antimicrobial strains with molecular docking studies. Lead molecule (1E, 4E)-1-(7-chloro-3-isopropylquinoxalin-2(1H)-ylidene) thiosemicarbazide was synthesized and condensed with various substituted acetophenones to synthesize derivatives. All derivatives were characterized by IR., NMR & Mass spectroscopy. The synthesized derivatives were evaluated in-vitro for antibacterial and antifungal activities against various strains using the agar dilution method. Molecular docking studies of the derivatives (Va – Vg) were performed against E. coli DNA gyrase B and Topoisomerase IV to find out essential binding sites against target protein PDB: 1AJ6 and 1S14, respectively. Among all these compounds,Vf and Vg were found to exhibit more potent activity against Gram –Ve, Gram +Ve bacterial and fungal strains at MIC 0.19 µg/ml, 0.39µg/ml, and 0.78 µg/ml, respectively. The docking studies of all the compounds exhibit potent binding energy, but the compound Vg exhibit interactive binding energy -8.1 and -7.5 kcal/mol to the active pockets...
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Posted by admin on Jun 30, 2021 in |
Rivastigmine is used for the treatment of mild to moderate dementia of the Alzheimer’s type. Transdermal delivery of Rivastigmine is preferable to improve gastrointestinal tolerability. A novel transdermal system with zero-order release kinetics was developed following a hybrid technique in a combination of the micro reservoir and adhesive dispersion system. The transdermal system was prepared by incorporating rivastigmine in adhesive matrix layer in which rivastigmine-loaded microspheres were dispersed. Microspheres were prepared by spray drying using poly-e-caprolactone and maltodextrin (1:1 ratio) as carriers in various drug: polymer ratios. Microspheres with1:2 drug: polymer ratio (A1) showed desired particle size, yield, assay and in-vitro drug release and were found to be suitable for designing the transdermal system. A1 was dispersed into silicon adhesive layer during the preparation of the patch with a calculated amount of rivastigmine. Transdermal patch with 18 mg rivastigmine was optimized by evaluating ratios of adhesive matrix and microsphere content following DOE where 13 formulations were evaluated for various physical and chemical properties. 5 among 13 formulations were found...
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Posted by admin on Jun 30, 2021 in |
The unripe fruit of Meyna spinosa / Laxiflora is used for the treatment of diabetes by traditional healers. The effect of the aqueous extract of the fruit is investigated on the normal and elevated blood glucose level of the experimental animal rats. The blood glucose level of the rats is elevated with the administration of I.P streptozotocin. The estimation of the blood glucose level is done by using a kit based on the glucose oxidase method. The rat has a blood glucose level above 280mg/dl is considered for the normal and anti-hyperglycemic study. The doses of the extract are selected as 200, 300mg/kg, and the route of administration is oral. The effect of the extract on the normal and elevated glucose level of the rat is compared with that of the standard drugs- glibenclamide and metformin. The effect of the extract on normal blood glucose level is not significant when compared with that of glibenclamide, whereas the effect of the extract on elevated blood glucose level is significant when...
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Posted by admin on Jun 30, 2021 in |
Background and Objectives: Cyanobacteria are rich in various bioactive compounds. This study aims to screen the antimicrobial activity of sub-aerial Cyanobacteria isolated from sub-aerial habitats (Old monuments and building facades). Materials and Methods: Crude aqueous and organic extracts were screened for phytochemical constituents and tested for their antimicrobial efficacy against human pathogens. The crude extract that showed better antimicrobial activities were further fractionated by column chromatography and purified by TLC. The active bands were scraped out separately and concentrated in vacuo to isolate pure compounds. Each purified compounds dissolved in respective solvents, assayed for antimicrobial activities were further characterised through FTIR and LC-MS. Results: The results indicated the presence of many secondary metabolites. Of the isolated purified compounds, the compounds from three species, viz. Scytonema hyalinum, Tolypothrix rechingeri, and Fischerella species exhibited antimicrobial activities, whereas others showed antibacterial activity. The FTIR spectra revealed the peaks of carboxylic acid, alkaloids, and phenolic compounds. The chemical compounds were identified as 1,3-dihydroxycyclohexane [Lyngbya kuetzingiana], 4-(4-hydroxyphenyl) butanoic acid [Nostoc linckia], octahydro-1H-indole-2-carboxylic acid [Scytonema...
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