Posted by admin on Jun 30, 2021 in |
Ginger or Zingiber officinale, Roscoe of the Zingiberaceae family is a rhizome that is widely found and most consumed in South east Asian countries; also used as a traditional remedy to treat various ailments like nausea, vomiting, pain, arthritis, indigestion, gastro reflux, cardiovascular disease, diabetes, obesity, microbes, cancer, inflammation, oxidation, and wounds to name some of its activity which is based on the various chemical constituents present in ginger as it is found to contain more than 400 different compounds which include sugar, protein, and fats. The major phenolic active constituents of ginger are 6-gingerol, 6-shogaol and 6- paradol; which are safe and showing only a few insignificant adversarial effects. Here, this review aims to summarize and discuss the ideas on how ginger is formulated and improve from conventional to novel formulations using novel techniques; to improve the pharmacological, biopharmaceutical and chemical properties of ginger extract and its compounds. Different novel formulations of ginger like a tablet, capsule, powder, cream, gel, transdermal patch, nanoparticles, liposomes and phytosomes along with...
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Posted by admin on Jun 30, 2021 in |
Linalool is the first ingredient to synthesize many other substances of higher value for the pharmaceutical and fragrance industry; therefore, finding sources of essential oils containing Linalool is an important and necessary task. The purpose of this study is to investigate Linalool of plants containing essential oil in Vietnam to extract Linalool sources for the pharmaceutical and fragrance industry. By the method of fresh sampling of essential oil plants in Vietnam, essential oils are extracted by steam distillation and then analyze on high-resolution chromatography (HRGC) to search for Linalool sources. We have found that some areas with a lot of plants containing high Linalool content grow concentrated wild in forests as Coriandrum sativum Linn., Homalomena occulta (Lour.) Schoot, Cinnamomum parthenoxylon Meissn, and some of them can be planned to cultivate the essential oil source to obtain Linalool for the pharmaceutical and aromatic industry. During the survey, we discovered and made a list of 21 plants with essential oil containing Linalool in...
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Posted by admin on Jun 30, 2021 in |
World Health Organization (WHO) designated the COVID-19 or more commonly called Coronavirus disease, a “public health emergency of international concern” on January 30, 2020, and declared it a pandemic on March 11, 2020, which threatens human wellbeing around the world. With no proven pharmacological treatment, therapy (such as plasma, bacteriophage, virophage) drug approved by Food and Drug Administration (FDA) against COVID-19 and the frequent transmission of infection resulting in progression of infected person; made the situation more critical. The critical pandemic situation created by COVID-19 realized that nutrition becomes a priority to boost immune function as what we eat can have severe health impacts and medical consequences. The present assessment focused on enhancing awareness among people to maintain a healthy lifestyle through balanced food, nutrition, and eating habits, and AYUSH recommendations to overcome inevitably caused distress due to pandemic...
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Posted by admin on Jun 30, 2021 in |
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs like BCS class III drugs, BCS class IV drugs. Applications of this technology can also be extended to macromolecules as well as small molecule drugs that are lipophilic with poor oral bioavailability. It is appropriate for oral as well as systemic administration of biologically active molecules, including drugs, genes, proteins, peptides, and vaccine antigens. This article covers multiple aspects of Nanocochleate drug delivery system, such as its definition, composition, method of preparation, and mechanism of permeation. The article also elaborates on various advantages, disadvantages, and applications of Nanocochleate drug delivery system. The article highlights the potential of this novel system for oral as well as systemic delivery of chemical and biological drug...
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Posted by admin on Jun 30, 2021 in |
The present study aimed to explore the primary metabolites present in leaf, fruit, and seed crude extracts of Syzygium cumini L by Gas chromatography – Mass spectrometry. The compounds in the leaf, seed, and fruit extracts resulted from the GC-MS analysis was relevant to the National Institute of Standards and Technology (NIST) library. The metabolite profiling of the extracts revealed the presence of carboxylic acid and fatty acid found to be common in leaf, fruit, and seed extracts. And metabolites 6-oxa-3-thiaoctanoic acid, bisoprolol, phenacetin, tropin, alizarin, gonodoic acid are present in seeds that are not found in leaves and fruit metabolite profile. In contrast, Tetra decanoic acid, Azelaic acid, Penicillamine and S (-)-Cathinone are found only in leaves. Leaf, fruit and seed extracts of Syzyzium cumini L contains various bioactive compounds and consequently has a variety of medicinal properties for the treatment of different diseases like thyroid cancer, heart diseases, kidney stones and rheumatoid arthritis. Some metabolites found to be active as antidiabetic, anti-inflammatory, anti-cancerous, antioxidant, anti-bacterial and antifungal...
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